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Intracellular sites of lipid synthesis and the biogenesis of mitochondria
Open accessAbstract
Experimental data are presented on the intracellular localization in rat liver of three enzymes which are involved in the biosynthesis of phosphatidylethanolamine and diphosphatidylglycerol. These enzymes are phosphatidylserine decarboxylase, CDP-diglyceride-l-alpha-glycerophosphate phosphatidyl transferase, and phosphatidylethanolamine-l-serine phosphatidyl transferase. It was found that the first two enzymes are primarily mitochondrial while the latter enzyme is primarily microsomal. The intracellular sites for the biosynthesis of phosphatidylcholine, phosphatidylethanolamine, and diphosphatidylglycerol are discussed, and the implications of their sites of biosynthesis on the assembly processes involved in the biogenesis of mitochondria are considered.
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Cited by
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Naon, D., & Scorrano, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.05.011 · Cited by 178
Metadata
- Authors
- Dennis, E. A., & Kennedy, E. P.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1972-03
- Volume
- 13
- Issue
- 2
- Pages
- 263-267
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2342453669
- Cited by
- 218
- References
- 0
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dennis, E. A., & Kennedy, E. P. (1972). Intracellular sites of lipid synthesis and the biogenesis of mitochondria. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)39421-9
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
