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Alpha 2 beta 1 integrins from different cell types show different binding specificities.
Open accessAbstract
Purified alpha 2 beta 1 integrin from human platelets was compared in its function and immunoreactivity to alpha 2 beta 1 from endothelial cells. Both alpha 2 beta 1 integrins bound to type I collagen-Sepharose and had indistinguishable immunoreactivities when analyzed by a panel of monoclonal and polyclonal alpha 2-specific antibodies. However, functional analysis using rechromatography of purified receptors on laminin and collagen-Sepharose showed that endothelial alpha 2 beta 1 was able to bind to laminin, whereas its counterpart from platelets did not. Moreover, a receptor binding assay indicated that, in contrast to platelets, endothelial cells might also use alpha 2 beta 1 to bind to fibronectin. These results suggest that the alpha 2 beta 1 binding specificity may be modulated by cell-type specific factors.
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Citations
Cited by
Ruoslahti, E. (1991) · Journal of Clinical Investigation · doi:10.1172/jci114957 · Cited by 1,381
Self-citationThe role of integrins in the maintenance of endothelial monolayer integrity.
Lampugnani, M. G., Resnati, M., Dejana, E., & Marchisio, P. C. (1991) · The Journal of cell biology · doi:10.1083/jcb.112.3.479 · Cited by 292
Massia, S. P., & Hubbell, J. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49672-5 · Cited by 287
Integrins as dynamic regulators of vascular function
Luscinskas, F. W., & Lawler, J. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.12.7522194 · Cited by 277
The α2 Integrin Subunit-Deficient Mouse
Chen, J., Diacovo, T. G., Grenache, D. G., Santoro, S. A., & Zutter, M. M. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64185-5 · Cited by 276
Metadata
- Authors
- Kirchhofer, D., Languino, L. R., Ruoslahti, E., & Pierschbacher, M. D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-01
- Volume
- 265
- Issue
- 2
- Pages
- 615-618
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1568828918
- Cited by
- 264
- References
- 0
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kirchhofer, D., Languino, L. R., Ruoslahti, E., & Pierschbacher, M. D. (1990). Alpha 2 beta 1 integrins from different cell types show different binding specificities. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)40093-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
