The role of integrins in the maintenance of endothelial monolayer integrity.

Lampugnani, M G; Resnati, M; Dejana, E; Marchisio, P C

doi:10.1083/jcb.112.3.479

Cited by 293Cell Adhesion Molecules ResearchCellular Mechanics and InteractionsBarrier Structure and Function Studies

The role of integrins in the maintenance of endothelial monolayer integrity.

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Lampugnani, M G, Resnati, M, Dejana, E, Marchisio, P C·1991·The Journal of cell biology

DOI 10.1083/jcb.112.3.479PMC PMC2288837

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Abstract

This paper shows that, in confluent human umbilical vein endothelial cell (EC) monolayers, the integrin heterodimers alpha 2 beta 1 and alpha 5 beta 1, but not other members of the beta 1 subfamily, are located at cell-cell contact borders and not at cellular free edges. Also the alpha v chain, but not its most common partner beta 3, that is widely expressed in EC cell-matrix junctions, is found at cell-cell borders. In EC monolayers, the putative ligands of alpha 2 beta 1 and alpha 5 beta 1 receptors, i.e., laminin, collagen type IV, and fibronectin, are also organized in strands corresponding to cell-cell borders. The location of the above integrin receptors is not an artifact of in vitro culture since it has been noted also in explanted islets of the native umbilical vein endothelium. The integrins alpha 2 beta 1 and alpha 5 beta 1 play a role in the maintenance of endothelial monolayer continuity in vitro. Indeed, specific antibodies to alpha 2 beta 1, alpha 5 beta 1, and the synthetic peptide GRGDSP alter its continuity without any initial cell detachment. Moreover, antibodies to alpha 5 beta 1 increase the permeation of macromolecules across confluent EC monolayers. In contrast beta 3 antibodies were ineffective. It is suggested that the relocation of integrins to cell-cell borders is a feature of cells programmed to form polarized monolayers since integrins have a different distribution in nonpolar confluent dermal fibroblasts. The conclusion is that some members of the integrin superfamily collaborate with other intercellular molecules to form lateral junctions and to control both the monolayer integrity and the permeability properties of the vascular endothelial lining. This also suggest that integrins are adhesion molecules provided with a unique biochemical adaptability to different biological functions.

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The scaffold function of inactive α5β1-integrin is independent of ECM binding.
“This function for inactive α5β1-integrin conformation is independent of ECM binding, providing a unique example of integrin noncanonical signaling in EC-EC junctions and explaining the long-standing puzzle of how integrins inhabit cell-cell junctions irrespective of matrix ligand binding (28, 29).”
From Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling (2026) · cites this paper as [29]
The paper reports α5β1 at endothelial cell–cell borders and says this localization did not depend on the substrate on which the cells were initially grown (p. 482). It does not establish that α5β1 was inactive or had an ECM-binding-independent scaffold function: the discussion considers a possible role for matrix ligands, and the authors say their evidence is inconclusive (p. 487). (LLM, conf=0.85)
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Integrins: A family of cell surface receptors
HYNES, R. (1987) · Cell · doi:10.1016/0092-8674(87)90233-9 · Cited by 4,294 · cited 1× · see citing works
“Most EC receptors for extraeellular matrix proteins belong to the integrin superfamily (Hynes, 1987).”
JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA
Farquhar, M. G., & Palade, G. E. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.375 · Cited by 3,637 · cited 1× · see citing works
“In epithelial cells, cell-cell adhesions have been widely studied (Farquhar and Palade, 1963) and specific proteins belonging to the CAM superfamily have been identified (for review see Edelman, 1986, 1988; Takeichi, 1988).”
Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton
Burridge, K., Fath, K. R., Kelly, T. J., Nuckolls, G. H., & Turner, C. E. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.002415 · Cited by 2,120 · cited 3× · see citing works
“…matrix proteins requires the organization, both in vivo (H~ittner et al., 1985; Drenckhahn and Wagner, 1986; White and Fujiwara, 1986) and in vitro, of firm adhesive structures on the basal side of the membrane called adhesion plaques (Dejana et al., 1987; for review see Burridge et al., 1988).”
VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site
Elices, M. J., Osborn, L., Takada, Y., Crouse, C., Luhowskyj, S., Hemler, M. E., & Lobb, R. R. (1990) · Cell · doi:10.1016/0092-8674(90)90661-w · Cited by 1,808 · cited 1× · see citing works
“ICAMq and ICAM-2 (Marlin and Springer, 1987; Stauton et al., 1989), o~ with V-CAM (Elices et al., 1990) or in leukocyte adhesion (Campanero et al., 1990).”
Laminin–a glycoprotein from basement membranes
Timpl, R., Rohde, H., Robey, P. G., Rennard, S. I., Foidart, J. M., & Martin, G. R. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83607-4 · Cited by 1,780 · see citing works
Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)
Marlin, S. D., & Springer, T. A. (1987) · Cell · doi:10.1016/0092-8674(87)90104-8 · Cited by 1,686 · see citing works
The cadherins: cell-cell adhesion molecules controlling animal morphogenesis
Takeichi, M. (1988) · Development · doi:10.1242/dev.102.4.639 · Cited by 1,615 · see citing works
Binding of soluble form of fibroblast surface protein, fibronectin, to collagen
Engvall, E., & Ruoslahti, E. (1977) · International Journal of Cancer · doi:10.1002/ijc.2910200102 · Cited by 1,433 · cited 1× · see citing works
“Human plasma FN was purified from freshly drawn citrated blood plasma by affinity chromatography (Engvall and Ruoslahti, 1977) on gelatinSepharose (Pharmacia, Uppsala, Sweden).”
Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
Pytela, R., Pierschbacher, M. D., & Ruoslahti, E. I. (1985) · Cell · doi:10.1016/0092-8674(85)90322-8 · Cited by 1,101 · cited 5× · see citing works
“, 1990), ~5/3~ that promotes their adhesion to FN (Pytela et al., 1985a; Argraves et al., 1987; Conforti et al., 1989) and txv/~3 (Pytela et al.”
Influential
Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.
Werb, Z., Tremble, P., Behrendtsen, O., Crowley, E., & Damsky, C. H. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.2.877 · Cited by 1,057 · cited 2× · see citing works
“The antibodies to a chains of the/31 integrin subfamily were: a mouse mAb to ~5 (B1E5; Werb et al., 1989 mune goat or rabbit sera and mouse IgGs were used as negative controls.”
PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.
Newman, P., Berndt, M., Gorski, J., White, G. C., Lyman, S., Paddock, C., & Muller, W. (1990) · Science · doi:10.1126/science.1690453 · Cited by 1,011 · cited 3× · see citing works
“The fluorescence signal along cell margins was not as continuous as that reported for other intercellular molecules like CD31 (Albelda et al., 1990; Newman et al., 1990; our unpublished observations) since it was somewhat intermittent along boundaries and more intense in some cell groups vs. others.”
Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1
Staunton, D. E., Dustin, M. L., & Springer, T. A. (1989) · Nature · doi:10.1038/339061a0 · Cited by 829 · see citing works
Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits.
Wayner, E. A., & Carter, W. G. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.4.1873 · Cited by 715 · see citing works
Human platelets possess an inducible and saturable receptor specific for fibrinogen.
Marguerie, G. A., Plow, E., & Edgington, T. S. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50603-7 · Cited by 705 · see citing works
Cell Adhesion Molecules in the Regulation of Animal Form and Tissue Pattern
Edelman, G. M. (1986) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.02.110186.000501 · Cited by 628 · cited 1× · see citing works
“In epithelial cells, cell-cell adhesions have been widely studied (Farquhar and Palade, 1963) and specific proteins belonging to the CAM superfamily have been identified (for review see Edelman, 1986, 1988; Takeichi, 1988).”
Background
The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells.
Carter, W. G., Wayner, E. A., Bouchard, T. S., & Kaur, P. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.4.1387 · Cited by 621 · see citing works
Capillary endothelial cell cultures: phenotypic modulation by matrix components.
Madri, J. A., & Williams, S. K. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.1.153 · Cited by 606 · cited 1× · see citing works
“The latter matrix molecules are indeed produced by EC (Jaffe and Mosher, 1978; Madri and Williams, 1983; Kramer et al., 1985) and are concentrated in strands corresponding to cell-cell interaction rims.”
Amino acid sequence of the human fibronectin receptor.
Argraves, W. S., Suzuki, S., Arai, H., Thompson, K. A., Pierschbacher, M. D., & Ruoslahti, E. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.3.1183 · Cited by 585 · cited 2× · see citing works
“…to collagen and fibronectin (FN) (Languino et al., 1989; Kirchhofer et al., 1990), ~5/3~ that promotes their adhesion to FN (Pytela et al., 1985a; Argraves et al., 1987; Conforti et al., 1989) and txv/~3 (Pytela et al., 1985b; Suzuki et al., 1987) which binds to vitronectin (VN) and other…”
Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.
Cheresh, D. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.18.6471 · Cited by 569 · cited 1× · see citing works
“…et al., 1990), ~5/3~ that promotes their adhesion to FN (Pytela et al., 1985a; Argraves et al., 1987; Conforti et al., 1989) and txv/~3 (Pytela et al., 1985b; Suzuki et al., 1987) which binds to vitronectin (VN) and other substrata (Charo et al., 1987; Cheresh, 1987; Dejana et al., 1989, 1990).”
Background
A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.
Pytela, R., Pierschbacher, M. D., & Ruoslahti, E. I. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.17.5766 · Cited by 513 · see citing works
Novel purification of vitronectin from human plasma by heparin affinity chromatography.
Yatohgo, T., Izumi, M., Kashiwagi, H., & Hayashi, M. (1988) · Cell Structure and Function · doi:10.1247/csf.13.281 · Cited by 510 · cited 1× · see citing works
“Human plas~na VN was purified from human plasma by affinity chromatography on heparin-Sepharose as described (Yatohgo et al., 1988).”
Morphoregulatory molecules
Edelman, G. M. (1988) · Biochemistry · doi:10.1021/bi00410a001 · Cited by 459 · see citing works
Synthesis of fibronectin by cultured human endothelial cells.
JAFFE, E. A., & Mosher, D. F. (1978) · The Journal of Experimental Medicine · doi:10.1084/jem.147.6.1779 · Cited by 456 · cited 1× · see citing works
“The latter matrix molecules are indeed produced by EC (Jaffe and Mosher, 1978; Madri and Williams, 1983; Kramer et al., 1985) and are concentrated in strands corresponding to cell-cell interaction rims.”
EndoCAM: a novel endothelial cell-cell adhesion molecule.
Albelda, S. M., Oliver, P., Romer, L. H., & Buck, C. A. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.4.1227 · Cited by 402 · cited 14× · see citing works
“Immunocytochemical topography of the ~x5 integrin chain (b) and of the intercellular adhesion molecule CD31/PECAM-I (d) in par[i'ally confluent EC. a and c show F-PHD staining of the same fields for F-actin.”
Influential
A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions.
Muller, W. A., Ratti, C. M., McDonnell, S. L., & Cohn, Z. A. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.2.399 · Cited by 358 · see citing works
Endothelial cells use alpha 2 beta 1 integrin as a laminin receptor.
Languino, L. R., Gehlsen, K. R., Wayner, E. A., Carter, W. G., Engvall, E., & Ruoslahti, E. I. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.5.2455 · Cited by 353 · see citing works
A novel vitronectin receptor integrin (αvβx) is responsible for distinct adhesive properties of carcinoma cells
Cheresh, D. A., Smith, J. W., Cooper, H. M., & Quaranta, V. (1989) · Cell · doi:10.1016/0092-8674(89)90172-4 · Cited by 341 · cited 2× · see citing works
“These data suggest that alternative integrin(s) sharing the C~v chain, such as the recently described ctJ3~ (Freed et al., 1989), av/3~ (Cheresh et al., 1989; Smith et al., 1990), aJ31 (Bodary and McLean, 1990; Vogel et al., 1990), av/3n (Dedhar and Gray, 1990) or unknown combinations, may also be…”
Novel function for beta 1 integrins in keratinocyte cell-cell interactions.
Larjava, H., Peltonen, J. T. K., Akiyama, S. K., Yamada, S. S., Gralnick, H. R., Uitto, J., & Yamada, K. M. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.3.803 · Cited by 337 · cited 1× · see citing works
“A similar distribution for ct2/~1 and et3~l has been reported in keratinocytes (Carter et al., 1990; De Luca et al., 1990; Larjava et al., 1990) and ot3/$t in many different normal and transformed cell types (Kaufmann et al., 1989) and suggested to be responsible for the onset and maintenance of…”
Background
A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody.
Sonnenberg, A., Janssen, H., Hogervorst, F. B. L., Calafat, J., & Hilgers, J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61123-8 · Cited by 324 · see citing works
A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).
Vogel, B., Tarone, G., Giancotti, F. G., Gailit, J. O., & Ruoslahti, E. I. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39268-3 · Cited by 292 · cited 1× · see citing works
“…integrin(s) sharing the C~v chain, such as the recently described ctJ3~ (Freed et al., 1989), av/3~ (Cheresh et al., 1989; Smith et al., 1990), aJ31 (Bodary and McLean, 1990; Vogel et al., 1990), av/3n (Dedhar and Gray, 1990) or unknown combinations, may also be involved in intercellular contacts.”
Background
Cell surface antigens of human bladder cancer defined by mouse monoclonal antibodies.
Fradet, Y., Cordon‐Cardo, C., Thomson, T. M., Daly, M. E., Whitmore, W. F., Lloyd, K. O., Melamed, M. R., & Old, L. J. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.1.224 · Cited by 271 · cited 1× · see citing works
“Woods (University of California Medical Center, San Diego, CA); mAb to or3 (J143; Fradet et al., 1984) from the laboratory of Dr.”
Alpha 2 beta 1 integrins from different cell types show different binding specificities.
Kirchhofer, D., Languino, L. R., Ruoslahti, E. I., & Pierschbacher, M. D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40093-8 · Cited by 264 · see citing works
Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cells.
Dejana, E., Colella, S., Conforti, G., Abbadini, M., Gaboli, M. P., & Marchisio, P. C. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.3.1215 · Cited by 253 · cited 9× · see citing works
“…of cell spreading and microfilament organization , fixed and permeabilized cells were stained with 2 #g/mi rhodamine-labeled phalloidin (R-PHD; Sigma Chemical Co.) for 30 min at 37°C. Indirect immunofluorescence experiments were performed as reported (e.g., Dejana et al., 1987, 1988b, 1990).”
BackgroundMethodInfluentialSelf-citation
The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex.
Kunicki, T. J., Nugent, D. J., Staats, S. J., Orchekowski, R. P., Wayner, E. A., & Carter, W. G. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68811-8 · Cited by 253 · cited 1× · see citing works
“Good candidates are matrix molecules such as FN, LM or collagen, all major ligands for ot2~t (Kunicki et al., 1988; Languino et al., 1989) and o~fl~ (Pytela et al., 1985a; Conforti et al., 1989).”
Background
The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.
Bodary, S. C., & McLean, J. W. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39269-5 · Cited by 251 · cited 1× · see citing works
“…integrin(s) sharing the C~v chain, such as the recently described ctJ3~ (Freed et al., 1989), av/3~ (Cheresh et al., 1989; Smith et al., 1990), aJ31 (Bodary and McLean, 1990; Vogel et al., 1990), av/3n (Dedhar and Gray, 1990) or unknown combinations, may also be involved in intercellular contacts.”
Background
Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin.
Smith, J. W., Vestal, D. J., Irwin, S., Burke, T. A., & Cheresh, D. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38549-7 · Cited by 236 · cited 1× · see citing works
“…suggest that alternative integrin(s) sharing the C~v chain, such as the recently described ctJ3~ (Freed et al., 1989), av/3~ (Cheresh et al., 1989; Smith et al., 1990), aJ31 (Bodary and McLean, 1990; Vogel et al., 1990), av/3n (Dedhar and Gray, 1990) or unknown combinations, may also be involved…”
Background
Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs.
Suzuki, S., Argraves, W. S., Arai, H., Languino, L. R., Pierschbacher, M. D., & Ruoslahti, E. I. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47907-0 · Cited by 218 · see citing works
Polarized integrin mediates human keratinocyte adhesion to basal lamina.
Luca, M. D., Tamura, R. N., Kajiji, S. M., Bondanza, S., Rossino, P., Cancedda, R., Marchisio, P. C., & Quaranta, V. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6888 · Cited by 210 · cited 2× · see citing works
“These data suggest that some well-defined/~ integrins have a specific topography in EC and also in other polarized cells (De Luca et al., 1990), where they contribute to define the typical polarity and the organization of epithelial layered tissues.”
Self-citation
Monoclonal antibodies in the analysis of fibronectin isoforms generated by alternative splicing of mRNA precursors in normal and transformed human cells.
Borsi, L., Carnemolla, B., Castellani, P., Rosellini, C., Vecchio, D., Allemanni, G., Chang, S. E., Taylor‐Papadimitriou, J., Pande, H., & Zardi, L. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.104.3.595 · Cited by 199 · cited 2× · see citing works
“A mouse mAb (IST-9) to the extra domain specifically expressed in cell-assembled FN and not in plasma FN (Borsi et al., 1987; CarnemoUa et al., 1987 All the antibodies were used in immunofluorescence microscopy at Ig concentrations ranging between 15 and 30 #g/mi.”
Stress fibers in the splenic sinus endothelium in situ: molecular structure, relationship to the extracellular matrix, and contractility.
Drenckhahn, D., & Wagner, J. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.5.1738 · Cited by 197 · cited 1× · see citing works
“…Francke et al., 1988); also, the anchoring of EC to subendothelial matrix proteins requires the organization, both in vivo (H~ittner et al., 1985; Drenckhahn and Wagner, 1986; White and Fujiwara, 1986) and in vitro, of firm adhesive structures on the basal side of the membrane called adhesion…”
Background
Molecular heterogeneity of adherens junctions.
Geiger, B., Volk, T., & Volberg, T. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.4.1523 · Cited by 197 · cited 2× · see citing works
“It has to be noticed, though, that vinculin, a cytoskeletal protein present in adhesion junctions of epithelial cells (Geiger et al., 1985), codistributed with integrins at EC borders while talin, that is absent from such junctions (Geiger et al., 1985; Nuckolls et al., 1990) did not.”
Background
Characterization of a novel differentiation antigen complex recognize by a monoclonal antibody (A-1A5): unique activation-specific molecular forms on stimulated T cells.
Hemler, M. E., Ware, C. F., & Strominger, J. L. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.1.334 · Cited by 181 · see citing works
Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix.
Charo, I. F., Bekeart, L., & Phillips, D. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61053-1 · Cited by 179 · see citing works
An alternative leukocyte homotypic adhesion mechanism, LFA-1/ICAM-1-independent, triggered through the human VLA-4 integrin.
Campanero, M. R., Pulido, R., Ursa, M. A., Rodríguez-Moya, M., Landázuri, M. O., & Sánchez‐Madrid, F. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.6.2157 · Cited by 172 · cited 1× · see citing works
“ICAMq and ICAM-2 (Marlin and Springer, 1987; Stauton et al., 1989), o~ with V-CAM (Elices et al., 1990) or in leukocyte adhesion (Campanero et al., 1990).”
Integrin VLA-3: ultrastructural localization at cell-cell contact sites of human cell cultures.
Kaufmann, R., Froesch, D., Westphal, C., Weber, L., & Klein, C. E. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.4.1807 · Cited by 162 · cited 1× · see citing works
“…for ct2/~1 and et3~l has been reported in keratinocytes (Carter et al., 1990; De Luca et al., 1990; Larjava et al., 1990) and ot3/$t in many different normal and transformed cell types (Kaufmann et al., 1989) and suggested to be responsible for the onset and maintenance of cell association.”
Background
A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C.
Freed, E., Gailit, J. O., van der Geer, P., Ruoslahti, E. I., & Hunter, T. R. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08445.x · Cited by 161 · cited 1× · see citing works
“These data suggest that alternative integrin(s) sharing the C~v chain, such as the recently described ctJ3~ (Freed et al., 1989), av/3~ (Cheresh et al., 1989; Smith et al., 1990), aJ31 (Bodary and McLean, 1990; Vogel et al., 1990), av/3n (Dedhar and Gray, 1990) or unknown combinations, may also be…”
Background
Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen.
Simmons, D. L., Walker, C., Power, C., & Pigott, R. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.6.2147 · Cited by 160 · see citing works
Use of the monoclonal antibody 12F1 to characterize the differentiation antigen VLA-2.
Pischel, K. D., Hemler, M. E., Huang, C.-M., Bluestein, H. G., & Woods, V. L. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.1.226 · Cited by 150 · cited 1× · see citing works
“Antibodies to the a chains of the/31 integrin subgroup were: a mAb to ¢2 (12FI; Pischel et al., 1987) kindly provided by Dr.”
The fibronectin receptor is organized by extracellular matrix fibronectin: implications for oncogenic transformation and for cell recognition of fibronectin matrices.
Roman, J., Lachance, R. M., Broekelmann, T. J., Kennedy, C. J., Wayner, E. A., CARTER, W. G., & McDonald, J. A. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.6.2529 · Cited by 148 · cited 2× · see citing works
“Old (Memorial SloanKettering Cancer Center, New York); a rabbit antiserum to the c~5 cytoplasmic domain (Roman et al., 1989) kindly donated by Dr.”
Fibrinogen induces adhesion, spreading, and microfilament organization of human endothelial cells in vitro.
Dejana, E., Colella, S., Languino, L. R., Balconi, G., Corbascio, G. C., & Marchisio, P. C. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.104.5.1403 · Cited by 146 · cited 5× · see citing works
“…of cell spreading and microfilament organization , fixed and permeabilized cells were stained with 2 #g/mi rhodamine-labeled phalloidin (R-PHD; Sigma Chemical Co.) for 30 min at 37°C. Indirect immunofluorescence experiments were performed as reported (e.g., Dejana et al., 1987, 1988b, 1990).”
InfluentialSelf-citation
Mechanism-based inactivation of horseradish peroxidase by sodium azide. Formation of meso-azidoprotoporphyrin IX
de Montellano, P. R. O., David, S., Ator, M. A., & Tew, D. (1988) · Biochemistry · doi:10.1021/bi00415a013 · Cited by 142 · see citing works
Von Willebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism.
Dejana, E., Lampugnani, M. G., Giorgi, M., Gaboli, M. P., Federici, A. B., Ruggeri, Z. M., & Marchisio, P. C. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.1.367 · Cited by 110 · cited 4× · see citing works
“…1:20 goat antiserum to otsfl~. F-actin was stained with R-PHD. x400. bodies to FN and LM were inactive in inducing minute flaws in the monolayer and, thus, in inhibiting cell-cell interaction (data not shown) while they were potent in blocking cell-substrate adhesion (Dejana et al., 1989, 1990).”
BackgroundInfluentialSelf-citation
Expression and intracellular distribution of stress fibers in aortic endothelium.
White, G. E., & Fujiwara, K. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.1.63 · Cited by 107 · cited 1× · see citing works
“, 1988); also, the anchoring of EC to subendothelial matrix proteins requires the organization, both in vivo (H~ittner et al., 1985; Drenckhahn and Wagner, 1986; White and Fujiwara, 1986) and in vitro, of firm adhesive structures on the basal side of the membrane called adhesion plaques (Dejana et al.”
Identification of a Ca2(+)-dependent cell-cell adhesion molecule in endothelial cells.
Heimark, R. L., Degner, M., & Schwartz, S. M. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.5.1745 · Cited by 106 · see citing works
Tight junctions. Their structure, composition, and function.
Schneeberger, E. E., & Lynch, R. D. (1984) · Circulation Research · doi:10.1161/01.res.55.6.723 · Cited by 101 · cited 1× · see citing works
“Morphological studies in vivo and in situ have shown the presence of tight junctions, adherens junctions, and gap junctions between adjacent endothelial cells (EC) t (Schneeberger and Lynch, 1984; Francke et al., 1988); also, the anchoring of EC to subendothelial matrix proteins requires the organization, both in vivo…”
Human vascular endothelial cells express a membrane protein complex immunochemically indistinguishable from the platelet VLA-2 (glycoprotein Ia-IIa) complex
Giltay, J. C., Brinkman, H. J. M., Modderman, P. W., Borne, A. E. G. K. V. D., & van MOURIK, J. A. (1989) · Blood · doi:10.1182/blood.v73.5.1235.1235 · Cited by 92 · see citing works
Fibrinogen induces endothelial cell adhesion and spreading via the release of endogenous matrix proteins and the recruitment of more than one integrin receptor
Dejana, E., Lampugnani, M. G., Giorgi, M., Gaboli, M. P., & Marchisio, P. (1990) · Blood · doi:10.1182/blood.v75.7.1509.1509 · Cited by 91 · see citing works
Self-citation
Localization of the cellular‐fibronectin‐specific epitope recognized by the monoclonal antibody IST‐9 using fusion proteins expressed in E. coli
Carnemolla, B., Borsi, L., Zardi, L., Owens, R. J., & Baralle, F. E. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80160-6 · Cited by 90 · see citing works
Functional studies of the domains of talin.
Nuckolls, G. H., Turner, C. E., & Burridge, K. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.5.1635 · Cited by 81 · cited 1× · see citing works
“It has to be noticed, though, that vinculin, a cytoskeletal protein present in adhesion junctions of epithelial cells (Geiger et al., 1985), codistributed with integrins at EC borders while talin, that is absent from such junctions (Geiger et al., 1985; Nuckolls et al., 1990) did not.”
Background
Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v.
Dedhar, S., & Gray, V. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.6.2185 · Cited by 79 · cited 1× · see citing works
“…integrin(s) sharing the C~v chain, such as the recently described ctJ3~ (Freed et al., 1989), av/3~ (Cheresh et al., 1989; Smith et al., 1990), aJ31 (Bodary and McLean, 1990; Vogel et al., 1990), av/3n (Dedhar and Gray, 1990) or unknown combinations, may also be involved in intercellular contacts.”
Background
SYNTHESIS OF FIBRONECTIN BY CULTURED HUMAN ENDOTHELIAL CELLS
JAFFE, E. A., & Mosher, D. F. (1978) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1978.tb16797.x · Cited by 78 · see citing works
Interaction of fibronectin with cultured human endothelial cells: characterization of the specific receptor
Conforti, G., Zanetti, A., Colella, S., Abbadini, M., Marchisio, P., Pytela, R., Giancotti, F. G., Tarone, G., Languino, L. R., & Dejana, E. (1989) · Blood · doi:10.1182/blood.v73.6.1576.1576 · Cited by 73 · see citing works
Self-citation
Aortic endothelial cell during regeneration. Remodeling of cell junctions, stress fibers, and stress fiber-membrane attachment domains.
Hüttner, I., Walker, C. A., & Gabbiani, G. (1985) · PubMed · Cited by 63 · see citing works
Type IV collagen synthesis by cultured human microvascular endothelial cells and its deposition into the subendothelial basement membrane
Kramer, R. H., Fuh, G.-M., & Karasek, M. A. (1985) · Biochemistry · doi:10.1021/bi00346a059 · Cited by 58 · cited 1× · see citing works
“The latter matrix molecules are indeed produced by EC (Jaffe and Mosher, 1978; Madri and Williams, 1983; Kramer et al., 1985) and are concentrated in strands corresponding to cell-cell interaction rims.”
Passage of low density lipoproteins through monolayers of human arterial endothelial cells. Effects of vasoactive substances in an in vitro model.
Langeler, E. G., Snelting-Havinga, I., & van Hinsbergh, V. W. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.4.550 · Cited by 55 · see citing works
Characterization of an In Vitro Model to Study the Permeability of Human Arterial Endothelial Cell Monolayers
Langeler, E. G., & van Hinsbergh, V. W. M. (1988) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1647038 · Cited by 55 · see citing works
Evidence that Vascular Endothelial Cells Can Induce the Retraction of Fibrin Clots
Barbieri, B., Balconi, G., Dejana, E., & Donati, M. B. (1981) · Experimental Biology and Medicine · doi:10.3181/00379727-168-41260 · Cited by 52 · cited 2× · see citing works
“Human endothelial cells (EC) were isolated from umbilical vein (Barbieri et al., 1981) by treatment with collagenase (0.1% from Clostridium histolyticum , Boehringer, Mannheim, FRG) for 20 rain at 37°C.”
InfluentialSelf-citation
The localization of a platelet GpIIb-IIIa-related protein in endothelial cell adhesion structures
Dejana, E., Languino, L. R., Colella, S., Corbascio, G., Plow, E., Ginsberg, M. H., & Marchisio, P. (1988) · Blood · doi:10.1182/blood.v71.3.566.566 · Cited by 47 · see citing works
Self-citation
The Endothelial Junction
Franke, W. W., Cowin, P., Gründ, C., Kuhn, C., & Kapprell, H. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0937-6_7 · Cited by 46 · see citing works
Modulation of Ca2+‐dependent intercellular adhesion in bovine aortic and human umbilical vein endothelial cells by heparin‐binding growth factors
Bavisotto, L. M., Schwartz, S. M., & Heimark, R. L. (1990) · Journal of Cellular Physiology · doi:10.1002/jcp.1041430106 · Cited by 26 · cited 3× · see citing works
“It has been recently found that Ca2*-dependent EC contact structure and molecular organization can be abolished by cell interaction with basic fibroblast growth factor or acidic fibroblast growth factor in the presence of heparin (Bavisotto et al., 1990).”
BackgroundResultInfluential

Flagged first, then by citations

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Signaling Mechanisms Regulating Endothelial Permeability
Mehta, D., & Malik, A. B. (2005) · Physiological Reviews · doi:10.1152/physrev.00012.2005 · Cited by 1,711 · see citing works
Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis
Bazzoni, G., & Dejana, E. (2004) · Physiological Reviews · doi:10.1152/physrev.00035.2003 · Cited by 1,384 · see citing works
Self-citation
Cytoskeletal regulation of pulmonary vascular permeability
Dudek, S. M., & Garcia, J. G. N. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.4.1487 · Cited by 985 · see citing works
Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle.
Lessey, B. A., Damjanovich, L., Coutifaris, C., Castelbaum, A. J., Albelda, S. Μ., & Buck, C. A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115835 · Cited by 640 · see citing works
“It has been postulated that these differences in distribution denote defined roles for these integrins (30-32).”
Background
A novel endothelial-specific membrane protein is a marker of cell-cell contacts.
Lampugnani, M. G., Resnati, M., Raiteri, M., Pigott, R., Pisacane, A., Houen, G., Ruco, L., & Dejana, E. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.6.1511 · Cited by 632 · see citing works
“Coverslip-attached cells were then fixed with paraformaldehyde and processed for immunofluorescence microscopy as previously described in detail (Lampugnani et al., 1991).”
BackgroundMethodInfluentialSelf-citation
Regulation of vascular endothelial barrier function
Lum, H., & Malik, A. B. (1994) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1994.267.3.l223 · Cited by 471 · see citing works
Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.
Rao, P., Pf, D., Kumar, J., & Epstein, D. L. (2001) · PubMed · Cited by 423 · see citing works
β 3 integrins mediate the cellular entry of hantaviruses that cause respiratory failure
Gavrilovskaya, I. N., Shepley, M. P., Shaw, R. D., Ginsberg, M. H., & Mackow, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7074 · Cited by 418 · see citing works
Laminins and human disease
McGowan, K. A., & Marinkovich, M. P. (2000) · Microscopy Research and Technique · doi:10.1002/1097-0029(20001101)51:3 · Cited by 75 · see citing works
Molecular mechanisms of endothelial hyperpermeability: implications in inflammation
Kumar, P., Shen, Q., Pivetti, C. D., Lee, E. S., Wu, M. H., & Yuan, S. Y. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409001112 · Cited by 379 · see citing works
Thrombin Inactivates Myosin Light Chain Phosphatase via Rho and Its Target Rho Kinase in Human Endothelial Cells
Essler, M., Amano, M., Kruse, H., Kaibuchi, K., Weber, P. C., & Aepfelbacher, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.21867 · Cited by 350 · see citing works
Cellular Entry of Hantaviruses Which Cause Hemorrhagic Fever with Renal Syndrome Is Mediated by β3Integrins
Gavrilovskaya, I. N., Brown, E. J., Ginsberg, M. H., & Mackow, E. R. (1999) · Journal of Virology · doi:10.1128/jvi.73.5.3951-3959.1999 · Cited by 338 · see citing works
Endothelial and Epithelial Cell Adhesion Molecules
Albelda, S. Μ. (1991) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/4.3.195 · Cited by 334 · see citing works
Thrombin-Induced Increase in Endothelial Permeability Is Associated With Changes in Cell-to-Cell Junction Organization
Rabiet, M., Plantier, J., Rival, Y., Genoux, Y., Lampugnani, M. G., & Dejana, E. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.3.488 · Cited by 316 · see citing works
Self-citation
ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters
Huang, R.-L., Teo, Z., Chong, H. C., Zhu, P., Tan, M., Tan, C. K., Lam, C. R. I., Sng, M. K., Leong, D. T., Tan, S., et al. (2011) · Blood · doi:10.1182/blood-2011-01-328716 · Cited by 284 · see citing works
Integrins as dynamic regulators of vascular function
Luscinskas, F. W., & Lawler, J. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.12.7522194 · Cited by 277 · see citing works
“In addition to functioning at the apical and basal surfaces, it has been reported that af3j, a2/31, and a5/31 are located at the endothelial cell-to-cell contact borders (39).”
Background
Functional Properties of Human Vascular Endothelial Cadherin (7B4/Cadherin-5), an Endothelium-Specific Cadherin
Breviario, F., Caveda, L., Corada, M., Martín-Padura, I., Navarro, P., Golay, J., Introna, M., Gulino, D., Lampugnani, M. G., & Dejana, E. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.8.1229 · Cited by 275 · see citing works
Self-citation
Regulation of Endothelial Cell Motility by Complexes of Tetraspan Molecules CD81/TAPA-1 and CD151/PETA-3 with α3β1 Integrin Localized at Endothelial Lateral Junctions
Yáñez‐Mó, M., Alfranca, A., Cabañas, C., Marazuela, M., Tejedor, R., Ursa, M. A., Ashman, L. K., Landázuri, M. O., & Sánchez‐Madrid, F. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.3.791 · Cited by 271 · see citing works
“The a2b1 and a5b1 integrins have previously been reported to localize at EC cell-to-cell junctions (Lampugnani et al., 1991), whereas a3b1 has been detected in cell– cell contact sites from other cell types, such as epithelial cells (Larjava et al.”
Influential
Mechanotransduction in endothelial cell migration
Li, S., Huang, N. F., & Hsu, S. H.-L. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20614 · Cited by 260 · see citing works
“Since integrins a5b1 and a2b1 are located at cell borders and maintain cell–cell adhesions [Lampugnani et al., 1991], it is possible that shear stress-activation of integrins may activate Src to phosphorylate catenins and VE–cadherin.”
Background
Protein Kinase C-α Signals Rho-Guanine Nucleotide Dissociation Inhibitor Phosphorylation and Rho Activation and Regulates the Endothelial Cell Barrier Function
Mehta, D., Rahman, A., & Malik, A. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101927200 · Cited by 256 · see citing works
Filovirus-induced endothelial leakage triggered by infected monocytes/macrophages
Feldmann, H., Bugany, H., Mahner, F., Klenk, H. D., Drenckhahn, D., & Schnittler, H. (1996) · Journal of Virology · doi:10.1128/jvi.70.4.2208-2214.1996 · Cited by 255 · see citing works
“Permeability assays were performed with a modified version of a previously published system (22).”
Method
Transplantation of discordant xenografts: a challenge revisited
Parker, W., Saadi, S., Lin, S. S., Holzknecht, Z. E., Bustos, M., & Platt, J. L. (1996) · Immunology Today · doi:10.1016/0167-5699(96)10028-1 · Cited by 254 · see citing works
The influence of micro-topography on cellular response and the implications for silicone implants
von Recum, A. F., & van Kooten, T. G. (1996) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856295x00698 · Cited by 251 · see citing works
Apoptosis induced by inhibition of intercellular contact.
Bates, R. C., Buret, A. G., Helden, D. F. V., Horton, M. A., & Burns, G. F. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.2.403 · Cited by 244 · see citing works
Targeted null-mutation in the vascular endothelial–cadherin gene impairs the organization of vascular-like structures in embryoid bodies
Vittet, D., Buchou, T., Schweitzer, A., Dejana, E., & Huber, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6273 · Cited by 227 · see citing works
Self-citation
Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle [published erratum appears in J Cell Biol 1994 Feb;124(3):395]
Palmer, E. L. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.5.1289 · Cited by 225 · see citing works
“Although integrins are not generally thought to be involved in homotypic cell-cell adhesion in non-leukocyte ceils, localization of integrins to cell-cell contacts has been shown for c~2fll in bronchial epithelial cells (1), cultured keratinocytes (6), and endothelial ceils (27); for t~3/31 in bronchial epithelial cel…”
Mechanisms of increased endothelial permeability
Lum, H., & Malik, A. B. (1996) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y96-081 · Cited by 222 · see citing works
“1988) and a dose-dependent increase of the transendothelial transport of horseradish peroxidase (Lampugnani et al. 1991).”
Background
Extrajunctional distribution of N-cadherin in cultured human endothelial cells
Salomon, D., Ayalon, O., Patel, R., Hynes, R. O., & Geiger, B. (1992) · Journal of Cell Science · doi:10.1242/jcs.102.1.7 · Cited by 207 · see citing works
Integrin-mediated cell adhesion: the extracellular face.
Loftus, J. C., Smith, J. W., & Ginsberg, M. H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47235-3 · Cited by 202 · see citing works
Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells.
Ayalon, O., Sabanay, H., Lampugnani, M. G., Dejana, E., & Geiger, B. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.1.247 · Cited by 197 · see citing works
“The third adhesion system found in endothelia includes various members of the integrin superfamily (Lampugnani et al., 1991).”
BackgroundSelf-citation
Polarized expression of integrin receptors (alpha 6 beta 4, alpha 2 beta 1, alpha 3 beta 1, and alpha v beta 5) and their relationship with the cytoskeleton and basement membrane matrix in cultured human keratinocytes.
Marchisio, P. C., Bondanza, S., Cremona, O., Cancedda, R., & Luca, M. D. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.112.4.761 · Cited by 197 · see citing works
Self-citation
Endothelial cell attachment and spreading on human tenascin is mediated by α2β1 and αVβ 3 integrins
Sriramarao, P., Mendler, M., & Bourdon, M. A. (1993) · Journal of Cell Science · doi:10.1242/jcs.105.4.1001 · Cited by 196 · see citing works
Inhibition of cultured cell growth by vascular endothelial cadherin (cadherin-5/VE-cadherin).
Caveda, L., Martín-Padura, I., Navarro, P., Breviario, F., Corada, M., Gulino, D., Lampugnani, M. G., & Dejana, E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118870 · Cited by 193 · see citing works
Self-citation
Making the cut: Protease-mediated regulation of angiogenesis
Roy, R., Zhang, B., & Moses, M. A. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.11.022 · Cited by 191 · see citing works
Regulation of Endothelial Barrier Function
Yuan, S. Y., & Rigor, R. R. (2011) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00025ed1v01y201101isp013 · Cited by 183 · see citing works
Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation*
Alexander, J. S., & Elrod, J. W. (2002) · Journal of Anatomy · doi:10.1046/j.1469-7580.2002.00057.x · Cited by 179 · see citing works
“Lampugnani et al. (1991) have also reported that human endothelium treated with cAMP analogues show a diffuse distribution of β1 and β3 integrins, actin and vinculin, which correlated with an apparent enhancement of adhesion to the substrate.”
Background
PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function
Sincock, P. M., Fitter, S., Parton, R. G., Berndt, M. C., Gamble, J. R., & Ashman, L. K. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.6.833 · Cited by 177 · see citing works
A second locus for hereditary hemorrhagic telangiectasia maps to chromosome 12.Preprint
Johnson, D. W., Berg, J. N., Gallione, C. J., McAllister, K. A., Warner, J. P., Helmbold, E. A., Markel, D. S., Jackson, C. E., Porteous, M. E., & Marchuk, D. A. (1995) · Genome Research · doi:10.1101/gr.5.1.21 · Cited by 176 · see citing works
Individually Distinct Ig Homology Domains in PECAM-1 Regulate Homophilic Binding and Modulate Receptor Affinity
Sun, Q., DeLisser, H. M., Zukowski, M. M., Paddock, C. M., Albelda, S. Μ., & Newman, P. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.19.11090 · Cited by 174 · see citing works
Suppression of RhoA Activity by Focal Adhesion Kinase-induced Activation of p190RhoGAP
Holinstat, M. A., Knežević, N. N., Broman, M., Samarel, A. M., Malik, A. B., & Mehta, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m511248200 · Cited by 164 · see citing works
Osteopontin and β 3 Integrin Are Coordinately Expressed in Regenerating Endothelium In Vivo and Stimulate Arg-Gly-Asp–Dependent Endothelial Migration In Vitro
Liaw, L., Lindner, V., Schwartz, S. M., Chambers, A. F., & Giachelli, C. M. (1995) · Circulation Research · doi:10.1161/01.res.77.4.665 · Cited by 163 · see citing works
Basic FGF and TGF-β differentially modulate integrin expression of human microvascular endothelial cells
Enenstein, J., Waleh, N. S., & Kramer, R. H. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90028-7 · Cited by 159 · see citing works
Immunohistochemical localization of adherens junction components in blood-brain barrier microvessels of the rat
Schulze, C., & Firth, J. A. (1993) · Journal of Cell Science · doi:10.1242/jcs.104.3.773 · Cited by 159 · see citing works
Mechanisms of fibrinogen‐induced microvascular dysfunction during cardiovascular disease
Lominadze, D. G., Dean, W. L., Tyagi, S. C., & Roberts, A. M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.02037.x · Cited by 146 · see citing works
“avb3 integrin was not found in intercellular contact regions (Lampugnani et al. 1991).”
BackgroundInfluential
Role of Integrin αvβ3 in Vascular Biology
Byzova, T. V., Rabbani, R., D’Souza, S. E., & Plow, E. F. (1998) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615250 · Cited by 143 · see citing works
Structural and functional aspects of intercellular junctions in vascular endothelium
Schnittler, H. (1998) · Basic Research in Cardiology · doi:10.1007/s003950050205 · Cited by 135 · see citing works
Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2
Murga, M., Fernández-Capetillo, Ó., & Tosato, G. (2004) · Blood · doi:10.1182/blood-2004-07-2598 · Cited by 132 · see citing works
Angiopoietin-Like 4 Interacts with Integrins β1 and β5 to Modulate Keratinocyte Migration
Goh, Y. Y., Pal, M., Chong, H. C., Zhu, P., Tan, M., Punugu, L., Lam, C. R. I., Yau, Y. H., Tan, C. K., Huang, R.-L., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100129 · Cited by 131 · see citing works
“Although this question is not directly addressed in this study, our data clearly showed that ANGPTL4 binds to integrin 1, and it has been shown that neutralizing antibody against integrin 5 1 increases paracellular endothelial permeability.(49) Altogether, our finding that ANGPTL4 interacts with integrins 1 and 5 to m…”
Background
Expression, topography, and function of integrin receptors are severely altered in keratinocytes from involved and uninvolved psoriatic skin.
Pellegrini, G., Luca, M. D., Orecchia, G. E., Balzac, F., Cremona, O., Savoia, P., Cancedda, R., & Marchisio, P. C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115782 · Cited by 131 · see citing works
“as previously shown in human cultured endothelial cells (10, 31), but no immunochemical indication has been obtained that new integrin heterodimeric combinations may occur (see”
BackgroundSelf-citation
Endothelial focal adhesions and barrier function
Wu, M. H. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.096537 · Cited by 127 · see citing works
“Indeed, some members of the integrins family have been identified as located at endothelial cell–cell borders (Lampugnani et al. 1991).”
Background
Integrins and reproductive physiology: expression and modulation in fertilization, embryogenesis, and implantation
Sueoka, K., Shiokawa, S., Miyazaki, T., Kuji, N., Tanaka, M., & Yoshimura, Y. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81388-x · Cited by 127 · see citing works
Expression of β1 integrin complexes on the surface of unfertilized mouse oocyte
Tarone, G., Russo, M. A., Hirsch, E., Odorisio, T., Altruda, F., Silengo, L., & Siracusa, G. (1993) · Development · doi:10.1242/dev.117.4.1369 · Cited by 126 · see citing works
Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos
Sousa, P. A. D., Valdimarsson, G., Nicholson, B. J., & Kidder, G. M. (1993) · Development · doi:10.1242/dev.117.4.1355 · Cited by 125 · see citing works
Approaches to studying cell adhesion molecules in angiogenesis
Bischoff, J. E. (1995) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)88949-7 · Cited by 120 · see citing works
Regulation of epithelial cell surface polarity reversal by β1 integrins
Ojakian, G. K., & Schwimmer, R. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.3.561 · Cited by 119 · see citing works
ECM-mediated glioma cell invasion
Goldbrunner, R., Bernstein, J. J., & Tonn, J. (1998) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19981101)43:3 · Cited by 65 · see citing works
Distinct mechanisms of interactions of Opc‐expressing meningococci at apical and basolateral surfaces of human endothelial cells; the role of integrins in apical interactions
Virji, M., Makepeace, K., & Moxon, E. R. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb01277.x · Cited by 116 · see citing works
Cellular Receptors and Hantavirus Pathogenesis
Mackow, E. R., & Gavrilovskaya, I. N. (2001) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-56753-7_6 · Cited by 115 · see citing works
Cell adhesion molecules in the pathogenesis of and host defence against microbial infection
Kerr, J. R. (1999) · Molecular Pathology · doi:10.1136/mp.52.4.220 · Cited by 113 · see citing works
Regulation of Endothelial Barrier Function by the cAMP-Dependent Protein Kinase
Patterson, C. E., Lum, H., Schaphorst, K. L., Verin, A. D., & Garcia, J. (2000) · Endothelium · doi:10.3109/10623320009072215 · Cited by 108 · see citing works
The angiopoietin-Tie2 signaling axis in the vascular leakage of systemic inflammation
Milam, K. E., & Parikh, S. M. (2014) · Tissue Barriers · doi:10.4161/21688362.2014.957508 · Cited by 104 · see citing works
“The interaction of integrins with the extracellular matrix helps root endothelial cells via focal adhesions to the basement membrane—as a result, integrins that serve as “receptors” for components of the ECM such as fibronectin have a critical role in the maintenance of endothelial barrier integrity.(43) However, a di…”
Background
Transglutaminase-mediated processing of fibronectin by endothelial cell monolayers
Martinez, J., Chalupowicz, D. G., Roush, R. K., Sheth, A., & Barsigian, C. (1994) · Biochemistry · doi:10.1021/bi00175a024 · Cited by 107 · see citing works
Complexus adhaerentes, a new group of desmoplakin-containing junctions in endothelial cells: II. Different types of lymphatic vessels
Schmelz, M., Moll, R., Kuhn, C., & Franke, W. W. (1994) · Differentiation · doi:10.1046/j.1432-0436.1994.5720097.x · Cited by 107 · see citing works
Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts.
Fawcett, J., Buckley, C., Holness, C. L. L., Bird, I. N., Spragg, J. H., Saunders, J., Harris, A. L., & Simmons, D. L. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.128.6.1229 · Cited by 107 · see citing works
Catechin reduces atherosclerotic lesion development in apo E-deficient mice: A transcriptomic study
Auclair, S., Milenković, D., Besson, C., Chauvet, S., Gueux, E., Morand, C., Mazur, A., & Scalbert, A. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.12.007 · Cited by 106 · see citing works
Dynamic platelet accumulation at the site of the occluded middle cerebral artery and in downstream microvessels is associated with loss of microvascular integrity after embolic middle cerebral artery occlusion
Zhang, Z. G., Zhang, L., Tsang, W., Goussev, A. V., Powers, C., Ho, K., Morris, D. C., Smyth, S. S., Coller, B. S., & Chopp, M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02735-4 · Cited by 106 · see citing works
Targeting endothelial permeability in the EPR effect
Lahooti, B., Akwii, R. G., Zahra, F. T., Sajib, M. S., Λάμπρου, Μ., Alobaida, A., Lionakis, M. S., Mattheolabakis, G., & Mikelis, C. M. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.07.039 · Cited by 106 · see citing works
Adhesion Molecules in the Lung: An Overview
Pilewski, J. M., & Albelda, S. Μ. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.6_pt_2.s31 · Cited by 104 · see citing works
Protein expression of brain endothelial cell E-cadherin after hypoxia/aglycemia: influence of astrocyte contact
Abbruscato, T. J., & Davis, T. P. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01778-3 · Cited by 103 · see citing works
Fibrinogen induces endothelial cell permeability
Tyagi, N., Roberts, A. M., Dean, W. L., Tyagi, S. C., & Lominadze, D. G. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9579-2 · Cited by 102 · see citing works
“Treatment of EC with anti-α5β1 integrin antibody has been reported to increase endothelial monolayer permeability [39,41].”
BackgroundInfluential
??-GALACTOSYL EPITOPE-MEDIATED ACTIVATION OF PORCINE AORTIC ENDOTHELIAL CELLS
Palmetshofer, A., Galili, U., Dalmasso, A. P., Robson, S. C., & Bach, F. H. (1998) · Transplantation · doi:10.1097/00007890-199804150-00018 · Cited by 96 · see citing works
Alpha 6.beta 1 integrin (laminin receptor) is down-regulated by tumor necrosis factor alpha and interleukin-1 beta in human endothelial cells.
Defilippi, P., Silengo, L., & Tarone, G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36960-1 · Cited by 95 · see citing works
Endothelial cells: adhesion and tight junctions
Rubin, L. L. (1992) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(92)90107-n · Cited by 94 · see citing works
A Perspective on Xenograft Rejection and Accommodation1
Platt, J. L. (1994) · Immunological Reviews · doi:10.1111/j.1600-065x.1994.tb00875.x · Cited by 94 · see citing works
“In other systems, anti-integrin antibodies have that property (Lampugnani et al. 1991).”
Background
Absence of Integrin αvβ3 Enhances Vascular Leak in Mice by Inhibiting Endothelial Cortical Actin Formation
Su, G., Atakilit, A., Li, J. T., Wu, N., Bhattacharya, M., Zhu, J., Shieh, J. E., Li, E., Chen, R., Sun, S., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201108-1381oc · Cited by 92 · see citing works
Talin-Dependent Integrin Activation Regulates VE-Cadherin Localization and Endothelial Cell Barrier Function
Pulous, F. E., Grimsley‐Myers, C. M., Kansal, S., Kowalczyk, A. P., & Petrich, B. G. (2019) · Circulation Research · doi:10.1161/circresaha.118.314560 · Cited by 93 · see citing works
VLA-4 integrin mediates lymphocyte migration on the inducible endothelial cell ligand VCAM-1 and the extracellular matrix ligand fibronectin.
Chan, P. Y., & Aruffo, A. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74516-5 · Cited by 93 · see citing works
Role of the extracellular matrix in age-related modifications of the rat aorta. Ultrastructural, morphometric, and enzymatic evaluations.
Fornieri, C., Quaglino, D., & Mori, G. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.9.1008 · Cited by 92 · see citing works
“Endothelial lining integrity is achieved by the presence of tight, adherent, and gap junctions between cells(21) and by surface integrins such as a2/31 or a5/31, whereas extracellular matrix proteins such as fibronectin or laminin do not seem to significantly interfere.(22) Because it has been demonstrated that integr…”
Background
An N‐cadherin–like protein contributes to solute barrier maintenance in cultured endothelium
Alexander, J. S., Blaschuk, O. W., & Haselton, F. R. (1993) · Journal of Cellular Physiology · doi:10.1002/jcp.1041560321 · Cited by 91 · see citing works
Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function
Mehta, D., Tiruppathì, C., Sandoval, R., Minshall, R. D., Holinstat, M. A., & Malik, A. B. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013289 · Cited by 90 · see citing works
Early heart development: Dynamics of endocardial cell sorting suggests a common origin with cardiomyocytes
Linask, K. K., & Lash, J. W. (1993) · Developmental Dynamics · doi:10.1002/aja.1001960108 · Cited by 90 · see citing works
“In addition endothelial cells have been shown to express integrins (Lampugnani et al., 1991).”
Background
Tetraspanins in intercellular adhesion of polarized epithelial cells: spatial and functional relationship to integrins and cadherins
Yáñez‐Mó, M., Tejedor, R., Rousselle, P., & Sánchez‐Madrid, F. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.3.577 · Cited by 89 · see citing works
Humoral Responses to Pig-to-Baboon Cardiac Transplantation: Implications for the Pathogenesis and Treatment of Acute Vascular Rejection and for Accommodation
McCurry, K. R., Parker, W., COTTERELL, A. H., Weidner, B. C., Lin, S. S., Daniels, L. J., Holzknecht, Z. E., Byrne, G. W., Diamond, L. E., Logan, J. S., et al. (1997) · Human Immunology · doi:10.1016/s0198-8859(97)00229-2 · Cited by 89 · see citing works
Immunoelectron characterisation of the inter-endothelial junctions of human term placenta
Leach, L., Clark, P., Lampugnani, M. G., Arroyo, A. G., Dejana, E., & Firth, J. A. (1993) · Journal of Cell Science · doi:10.1242/jcs.104.4.1073 · Cited by 87 · see citing works
Self-citation
Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma
O’Callaghan, J., Crosbie, D. E., Cassidy, P. S., Sherwood, J. M., Flügel‐Koch, C., Lütjen-Drecoll, E., Humphries, M. M., Reina‐Torres, E., Wallace, D., Kiang, A., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx028 · Cited by 87 · see citing works
Genes that Regulate Metastasis and Angiogenesis
Webb, C. P., & Woude, G. F. V. (2000) · Journal of Neuro-Oncology · doi:10.1023/a:1006466605356 · Cited by 86 · see citing works
Neutrophil transmigration, focal adhesion kinase and endothelial barrier function
Yuan, S. Y., Shen, Q., Rigor, R. R., & Wu, M. H. (2011) · Microvascular Research · doi:10.1016/j.mvr.2011.06.015 · Cited by 84 · see citing works
Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid β in guinea pigs
Martel, C. L., Mačkić, J. B., McComb, J. G., Ghiso, J. A., & Zloković, B. V. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)12462-9 · Cited by 82 · see citing works
Mechanisms of Endothelial Growth Control
D'Amore, P. A. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/6.1.1 · Cited by 82 · see citing works
The integrin coactivator Kindlin-2 plays a critical role in angiogenesis in mice and zebrafish
Pluskota, E., Dowling, J. J., Gordon, N., Golden, J. A., Szpak, D., West, X. Z., Nestor, C., Ma, Y., Białkowska, K., Byzova, T. V., et al. (2011) · Blood · doi:10.1182/blood-2010-11-321182 · Cited by 81 · see citing works
The platelet endothelial cell adhesion molecule‐1 (PECAM1) contributes to endothelial barrier function
Ferrero, E., Ferrero, M. E., Pardi, R., & Zocchi, M. R. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01110-z · Cited by 81 · see citing works
Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration
Bird, I. N., Taylor, V., Newton, J. P., Spragg, J. H., Simmons, D. L., Salmon, M., & Buckley, C. D. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.12.1989 · Cited by 81 · see citing works
Engineering small-caliber vascular grafts from collagen filaments and nanofibers with comparable mechanical properties to native vessels
Zhang, F., Xie, Y., Celik, H., Akkuş, O., Bernacki, S. H., & King, M. W. (2019) · Biofabrication · doi:10.1088/1758-5090/ab15ce · Cited by 80 · see citing works
Studies of lymphocyte transendothelial migration: analysis of migrated cell phenotypes with regard to CD31 (PECAM-1), CD45RA and CD45RO.
Bird, I. N., Spragg, J. H., Ager, A., & Matthews, N. (1993) · PubMed Central · Cited by 80 · see citing works
Phenotype of the Endothelium in the Human Term Placenta
Dye, J. F., Jablenska, R., Donnelly, J., Lawrence, L., Leach, L., Clark, P., & Firth, J. A. (2001) · Placenta · doi:10.1053/plac.2000.0579 · Cited by 77 · see citing works
Induction of IL-6 expression by mechanical stress in the trabecular meshwork
Liton, P. B., Luna, C., Bodman, M., Hong, A., Epstein, D. L., & González, P. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.182 · Cited by 76 · see citing works
Integrin binding to fibronectin and vitronectin maintains the barrier function of isolated porcine coronary venules
Wu, M. H., Ustinova, E. E., & Granger, H. J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0785e.x · Cited by 76 · see citing works
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17β-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells
Gierthy, J. F., Spink, B. C., Figge, H. L., Pentecost, B. T., & Spink, D. C. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19960201)60:2 · Cited by 40 · see citing works
Thrombin-mediated Focal Adhesion Plaque Reorganization in Endothelium: Role of Protein Phosphorylation
Schaphorst, K. L., Pavalko, F. M., Patterson, C. E., & Garcia, J. G. N. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.17.4.2502 · Cited by 75 · see citing works
“In addition, a functional role for cell‐matrix adhesion in determining EC permeability was revealed by the observation that antibodies directed at extracellular matrix receptors increased EC permeability ( 35 ).”
Background
Synthetic peptide containing Arg-Gly-Asp inhibits bone formation and resorption in a mineralizing organ culture system of fetal rat parietal bones
Gronowicz, G., & DeRome, M. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090208 · Cited by 75 · see citing works

Endothelial cells use alpha 2 beta 1 integrin as a laminin receptor.
Languino, L. R., Gehlsen, K. R., Wayner, E. A., Carter, W. G., Engvall, E., & Ruoslahti, E. I. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.5.2455 · Cited by 353 · see citing works
Human endothelial cells express integrin receptors on the luminal aspect of their membrane
Conforti, G., Domı́nguez-Jiménez, C., Zanetti, A., Gimbrone, M. J., Cremona, O., Marchisio, P., & Dejana, E. (1992) · Blood · doi:10.1182/blood.v80.2.437.437 · Cited by 136 · see citing works
Self-citation
A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions
Muller, A., Ratti, C. M., McDonnell, S. L., Zanvil, & Cohn, A. (1989)
Integrin α3-subunit expression modulates alveolar epithelial cell monolayer formation
Lubman, R. L., Zhang, X., Zheng, J., Ocampo, L., Lopez, M. Z., Veeraraghavan, S., Zabski, S. M., Danto, S. I., & Borok, Z. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.1.l183 · Cited by 13 · see citing works
Human microvascular endothelial cells use beta 1 and beta 3 integrin receptor complexes to attach to laminin.
Kramer, R. H., Cheng, Y., & Clyman, R. I. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.3.1233 · Cited by 154 · see citing works

Authors: Lampugnani, M. G., Resnati, M., Dejana, E., & Marchisio, P. C.
Affiliations: Mario Negri Institute for Pharmacological Research (IT)
ORCID: Lampugnani, M G
Resnati, M
Dejana, E
Venue: The Journal of cell biology
Publisher: Rockefeller University Press
Published: 1991-02-01
Volume: 112
Issue: 3
Pages: 479-490
ISSN: 0021-9525 (ISSN-L)
1540-8140
DOI: 10.1083/jcb.112.3.479
PMC: PMC2288837
OpenAlex: W2033393629
Cited by: 292
References: 71
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 4
FWCI: 8.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Cell Biology (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: integrins, endothelial monolayer integrity, alpha2beta1 integrin, alpha5beta1 integrin, alpha3beta1 integrin, cell-cell contact, CD61, laminin, type IV collagen, fibronectin, endothelial permeability, GRGDSP peptide, endothelial cell adhesion, lateral junctions
MeSH terms: Actins, Amino Acid Sequence, Antigen-Antibody Complex, Cell Membrane Permeability, Cells, Cultured, Cytoskeletal Proteins, Endothelium, Vascular, Fluorescent Antibody Technique, Humans, Molecular Sequence Data, Oligopeptides, Umbilical Veins, Integrins, Vinculin, Macromolecular Substances

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The role of integrins in the maintenance of endothelial monolayer integrity.

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