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Identification of a novel transforming growth factor-beta (TGF-beta 5) mRNA in Xenopus laevis.
Open accessAbstract
A novel transforming growth factor-beta (TGF-beta) mRNA of about 3.0 kilobases, which encodes a putative protein of 382 amino acids, has been identified in amphibians by cDNA cloning. This mRNA, which we designate as TGF-beta 5, is developmentally regulated and highly expressed beginning at early neurula (stage 14) and in many adult tissues in Xenopus laevis. Following the first methionine, the putative precursor protein has a hydrophobic region, approximately 22 amino acids long, which probably represents a signal sequence, similar to that found in TGF-beta s 1-3. The precursor also has potential sites for glycosylation, integrin binding (RGD), and a tetrabasic amino acid (RKKR) site for potential cleavage of the precursor peptide to a biologically active protein. The putative mature protein consists of 112 amino acids with 9 cysteines and has 76, 66, 69, and 72% identity to TGF-beta s 1-4, respectively.
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Citations
Cited by
The Transforming Growth Factor-βs
Roberts, A. B., & Sporn, M. B. (1990) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-49295-2_8 · Cited by 746
Self-citationOP-1 cDNA encodes an osteogenic protein in the TGF-beta family.
Ozkaynak, E., Rueger, D. C., Drier, E. A., Corbett, C., Ridge, R. J., Sampath, T. K., & Oppermann, H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07376.x · Cited by 554
Millan, F. A., Denhez, F., Kondaiah, P., & Akhurst, R. J. (1991) · Development · doi:10.1242/dev.111.1.131 · Cited by 498
Self-citationCrystal Structure of Transforming Growth Factor-β2: an Unusual Fold for the Superfamily
Daopin, S., Piez, K. A., Ogawa, Y., & Davies, D. R. (1992) · Science · doi:10.1126/science.1631557 · Cited by 440
Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase
Dubois, C. M., Laprise, M.-H., Blanchette, F., Gentry, L. E., & Leduc, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10618 · Cited by 405
Metadata
- Authors
- Kondaiah, P., Sands, M. J., Smith, J. M., Fields, A., Roberts, A. B., Sporn, M. B., & Melton, D. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-01
- Volume
- 265
- Issue
- 2
- Pages
- 1089-1093
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1573228711
- Cited by
- 172
- References
- 0
- FWCI
- 11.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Identification of a novel transforming growth factor-beta (TGF-beta 5) mRNA in Xenopus laevis. https://app.cochat.ai/papers/10.1016/s0021-9258(19)40162-2
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- Kondaiah, P., Sands, M. J., Smith, J. M., Fields, A., Roberts, A. B., Sporn, M. B., & Melton, D. A. (1990). Identification of a novel transforming growth factor-beta (TGF-beta 5) mRNA in Xenopus laevis. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)40162-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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