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Signaling through phosphatidylcholine breakdown.
Open accessAbstract
Several mechanisms of agonist control of PC hydrolysis have been described: control by G proteins, protein kinase C, Ca2+, and tyrosine kinases. The relative importance of these mechanisms remains to be demonstrated. Another major point is the physiological significance of PC hydrolysis. The prolonged formation of DAG from PC may be important in cellular control mechanisms that require long term activation of protein kinase C. The functions of PA are presently unknown, but the rapid formation of high concentrations of this lipid during stimulation by agonists strongly suggests that it has signaling functions. It is obvious that much work remains to define the physiological significance of agonist-stimulated PC breakdown.
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Cited by
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Fröhlich, E. E., Farzi, A., Mayerhofer, R., Reichmann, F., Jačan, A., Wagner, B., Zinser, E., Bordag, N., Magnes, C., Fröhlich, E., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.020 · Cited by 720
The gut microbiota modulates host energy and lipid metabolism in mice
Velagapudi, V. R., Hezaveh, R., Reigstad, C. S., Gopalacharyulu, P., Yetukuri, L., Islam, S., Felin, J., Perkins, R., Borén, J., Orešič, M., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m002774 · Cited by 589
Lewis, M., Tartaglia, L. A., Lee, A., Bennett, G. L., Rice, G. C., Wong, G. H., Chen, E. Y., & Goeddel, D. V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2830 · Cited by 567
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Metadata
- Authors
- Exton, J. H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-01
- Volume
- 265
- Issue
- 1
- Pages
- 1-4
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1508152421
- Cited by
- 1,348
- References
- 0
- FWCI
- 71.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Exton, J. H. (1990). Signaling through phosphatidylcholine breakdown. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)40184-1
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