The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Isolation and characterization of CNBr peptides of human (alpha 1 (III) )3 collagen and tissue distribution of (alpha 1 (I) )2 alpha 2 and (alpha 1 (III) )3 collagens.
Open accessAbstract
[Alpha 1(III)]3 collagen was solubilized by pepsin digestion of normal human placental membranes and was purified by differential salt precipitation and carboxymethylcellulose chromatography. This collagen was digested with CNBr, and the resultant nine peptides were isolated and characterized. The chains are cross-linked by cysteinyl residues in the COOH-terminal peptide. Isolation of peptides derived from CNBr digestion of insoluble tissues was used as an assay for the presence of [alpha 1(I)]2alpha 2 and [alpha 1(III)]3 collagens. Both types are present in human skin, intestine, liver, spleen, kidney, lung, aorta, umbilical cord, placental membranes, and myocardium. Bone and tendon contain [alpha 1(I)]2alpha 2 collagen but, unlike the other tissues, lack [alpha 1(III)]3 collagen. Both [alpha 1(I)]2alpha 2 and[alpha 1(III)]3 collagens are present in scars of human skin, myocardium, tendon, and liver and of rabbit skin. The degree of hydroxylation of proline was 4 to 5% lower in the same peptides in skin, bone, and tendon than in the other tissues. The degree of hydroxylation of lysine in the same peptides derived from different tissues varied more widely.
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Cites
A Heritable Disorder of Connective Tissue: Hydroxylysine-Deficient Collagen Disease
Pinnell, S. R., Krane, S. M., Kenzora, J. E., & Glimcher, M. J. (1972) · New England Journal of Medicine · doi:10.1056/nejm197205112861901 · Cited by 414
Cited by
Postlethwaite, A. E., Seyer, J. M., & Kang, A. H. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.2.871 · Cited by 730
CRYSTAL, R. G., FULMER, J. D., ROBERTS, W. C., MOSS, M. L., LINE, B. R., & REYNOLDS, H. Y. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-85-6-769 · Cited by 685
Liu, X., Wu, H., Byrne, M., Krane, S., & Jaenisch, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1852 · Cited by 614
Tendons and ligaments: A morphological and biochemical comparison
Amiel, D., Frank, C., Harwood, F., Fronek, J., & Akeson, W. (1983) · Journal of Orthopaedic Research · doi:10.1002/jor.1100010305 · Cited by 607
The estimation of two collagens from human dermis by interrupted gel electrophoresis
Sykes, B., Puddle, B., Francis, M., & Smith, R. (1976) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(76)80180-5 · Cited by 560
Metadata
- Authors
- Epstein, E., & Munderloh, N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1975-12
- Volume
- 250
- Issue
- 24
- Pages
- 9304-9312
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1491180863
- Cited by
- 168
- References
- 1
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Isolation and characterization of CNBr peptides of human (alpha 1 (III) )3 collagen and tissue distribution of (alpha 1 (I) )2 alpha 2 and (alpha 1 (III) )3 collagens. https://app.cochat.ai/papers/10.1016/s0021-9258(19)40644-3
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- Epstein, E., & Munderloh, N. (1975). Isolation and characterization of CNBr peptides of human (alpha 1 (III) )3 collagen and tissue distribution of (alpha 1 (I) )2 alpha 2 and (alpha 1 (III) )3 collagens. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)40644-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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