The DOI matches its Crossref record.
Purification from human plasma of a heparin-released lipase with activity against triglyceride and phospholipids.
Open accessAbstract
A triglyceride lipase different from lipoprotein lipase, but measurable only after intravenous heparin injection, has been isolated from human plasma by sequential use of heparin-Sepharose and concanavalin A-Sepharose affinity chromatography. Using these procedures, phospholipase A1 activity was found to chromatograph identically with the triglyceride lipase. The constancy of the ratio of activities after isoelectric focusing (pI 4.1) and during thermal deactivation indicates that this enzyme has hydrolase activity against both triglycerides and phospholipids. This conclusion was supported further by the homogeneity of the protein as indicated by sodium dodecyl sulfate polyacrylamide gel electrophoresis.
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Citations
Cited by
The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease
Long, J. Z., & Cravatt, B. F. (2011) · Chemical Reviews · doi:10.1021/cr200075y · Cited by 425
Adam, R. C., Mintah, I. J., Alexa-Braun, C. A., Shihanian, L. M., Lee, J. S., Banerjee, P., Hamon, S. C., Kim, H. I., Cohen, J. C., Hobbs, H. H., et al. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra120000888 · Cited by 208
Hepatic lipase is abundant on both hepatocyte and endothelial cell surfaces in the liver
Sanan, D. A., Fan, J., Bensadoun, A., & Taylor, J. M. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37224-2 · Cited by 72
Role of the Liver in the Degradation of Lipoproteins
Cooper, A. D. (1985) · Gastroenterology · doi:10.1016/s0016-5085(85)80155-4 · Cited by 45
Lipoprotein lipase in liver. Release by heparin and immunocytochemical localization
Vilaró, S., Ramírez, I., Bengtsson-Olivecrona, G., Olivecrona, T., & Llobera, M. (1988) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(88)90021-5 · Cited by 25
Metadata
- Authors
- Ehnholm, C., Shaw, W., Greten, H., & Brown, W. V.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1975-09
- Volume
- 250
- Issue
- 17
- Pages
- 6756-6761
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1520348962
- Cited by
- 205
- References
- 0
- FWCI
- 16.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ehnholm, C., Shaw, W., Greten, H., & Brown, W. V. (1975). Purification from human plasma of a heparin-released lipase with activity against triglyceride and phospholipids. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)40996-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
