The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Aggregation of Cartilage Proteoglycans
Open accessAbstract
Abstract A protein-hyaluronic acid complex was isolated from Sepharose 2B chromatography of a sequential chondroitinase plus trypsin digest of a proteoglycan aggregate preparation from bovine nasal cartilage. Two were subsequently isolated from this complex by Sephadex G-200 chromatography with 4 m guanidine hydrochloride as the eluent. Sodium dodecyl sulfate polyacrylamide gel electrophoresis showed that the two had molecular weights of about 90,000 and 45,000 and that treatment with β-mercaptoethanol did not decrease their sizes. The larger protein gave a broad, diffuse band in the gel, perhaps attributable to the 10 to 15% keratan sulfate present in this fraction. The larger protein accounted for 20%, and the smaller for 10% of the protein in the original proteoglycan aggregate preparation. Both retained their ability to bind to hyaluronic acid. Experiments with aggregate preparations reconstituted from mixtures with [3H]acetylated or unlabeled proteoglycans showed that the larger protein fraction is derived from a portion of the protein in the proteoglycan monomer molecules while the smaller is derived from one of the small molecular weight link proteins that are present in proteoglycan aggregate preparations.
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Cites
Weber, K., & Osborn, M. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94333-4 · Cited by 20,298
Proteinpolysaccharide Complex from Bovine Nasal Cartilage
Hascall, V., & Sajdera, S. W. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78236-2 · Cited by 668
Self-citationProteinpolysaccharide Complex from Bovine Nasal Cartilage
Sajdera, S. W., & Hascall, V. C. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78194-0 · Cited by 657
Self-citationThe specific interaction of hyaluronic acid with cartilage proteoglycans.
HARDINGHAM, T., & MUIR, H. (1972) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(72)90160-2 · Cited by 645
Aggregation of Cartilage Proteoglycans
Hascall, V. C., & Heinegård, D. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42507-6 · Cited by 562
Self-citationAggregation of Cartilage Proteoglycans
Hascall, V. C., & Heinegård, D. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42508-8 · Cited by 396
Self-citationPhysical Properties and Polydispersity of Proteoglycan from Bovine Nasal Cartilage
Hascall, V. C., & Sajdera, S. W. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62796-6 · Cited by 357
Self-citationHardingham, T., & Muir, H. (1972) · Biochemical Journal · doi:10.1042/bj1260791 · Cited by 91
Riordan, J. F., & Vallée, B. L. (1967) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(67)11068-9 · Cited by 78
Proteoglycans of cartilage: An assessment of their structure
TSIGANOS, C. P., Hardingham, T., & Muir, H. (1971) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(71)90216-9 · Cited by 71
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Structure and function of aggrecan
KIANI, C., CHEN, L., WU, Y. J., YEE, A. J., & YANG, B. B. (2002) · Cell Research · doi:10.1038/sj.cr.7290106 · Cited by 758
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Bandtlow, C. E., & Zimmermann, D. R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1267 · Cited by 632
Aging and osteoarthritis: Central role of the extracellular matrix
Rahmati, M., Nalesso, G., Mobasheri, A., & Mozafari, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.07.004 · Cited by 567
Proteoglycans in health and disease: structures and functions
Poole, A. R. (1986) · Biochemical Journal · doi:10.1042/bj2360001 · Cited by 450
Fell‐Muir Lecture: Proteoglycans and more – from molecules to biology
Heinegård, D. (2009) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2009.00695.x · Cited by 311
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Metadata
- Authors
- Heinegård, D., & Hascall, V. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1974-07
- Volume
- 249
- Issue
- 13
- Pages
- 4250-4256
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1492080952
- Cited by
- 484
- References
- 10
- FWCI
- 16.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
