The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily.
Open accessAbstract
Nuclear orpan receptors are members of the superfamily of structurally related, ligand-inducible transcription factors for which no ligand has yet been identified. Over the past few years many nuclear orphan receptors have been cloned, but only for the retinoid X receptor (RXR) has a natural ligand (9-cis-retinoic acid) been found. Here we report the identification of melatonin as a ligand for the recently cloned orphan receptor retinoid Z receptor beta (RZR beta). We found RZR beta expression in the rat brain nearly coincident with binding sites for the pineal gland hormone melatonin (5-methoxy-N-acetyltryptamine). We show here binding and activation of RZR beta by melatonin with Kd and EC50 values in the low nanomolar range. A nuclear signaling pathway for melatonin may contribute to some of the diverse and profound effects of this hormone, for example, in the context of circadian rhythmicity.
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Metadata
- Authors
- Becker-André, M., Wiesenberg, I., Schaeren-Wiemers, N., André, E., Missbach, M., Saurat, J. H., & Carlberg, C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-11
- Volume
- 269
- Issue
- 46
- Pages
- 28531-28534
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2016868037
- Cited by
- 434
- References
- 29
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by/4.0/ (vor, 9481 d)
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- Becker-André, M., Wiesenberg, I., Schaeren-Wiemers, N., André, E., Missbach, M., Saurat, J. H., & Carlberg, C. (1994). Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)61934-4
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