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Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking.
Open accessAbstract
The structure of receptors for insulin-like growth factors in rat liver plasma membranes and the BRL 3A2 rat liver cell line has been examined by chemical cross-linking with disuccinimidyl suberate and sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing and nonreducing conditions. Two receptor subtypes have been identified: (i) 125I multiplication-stimulating activity cross-linked to liver membranes or intact cells appeared in a complex of Mr = 260,000 (reduced) and 220,000 (nonreduced) and (ii) 125I-insulin-like growth factor I cross-linked to BRL 3A2 cells appeared predominantly in two bands of Mr greater than 300,000 without disulfide reduction and in a Mr = 130,000 complex following reduction. The two subtypes of insulin-like growth factor receptors identified by structural analysis correspond to previously observed differences in their specificity for insulin and insulin-like growth factors.
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Citations
Cited by
Growth factors: Mechanism of action and relation to oncogenes
Heldin, C.-H., & Westermark, B. (1984) · Cell · doi:10.1016/0092-8674(84)90296-4 · Cited by 854
Insulin-like growth factor II receptor as a multifunctional binding protein
Morgan, D. O., Edman, J. C., Standring, D. N., Fried, V. A., Smith, M. C., Roth, R. A., & Rutter, W. J. (1987) · Nature · doi:10.1038/329301a0 · Cited by 853
Massagué, J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43959-7 · Cited by 473
Kasuga, M., Zick, Y., Blith, D. L., Karlsson, F. A., Häring, H. U., & Kahn, C. R. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33955-3 · Cited by 437
Self-citationInsulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development.
McMorris, F. A., Smith, T. M., DeSalvo, S., & Furlanetto, R. W. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.3.822 · Cited by 386
Metadata
- Authors
- Kasuga, M., Van Obberghen, E., Nissley, S. P., & Rechler, M. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1981-06
- Volume
- 256
- Issue
- 11
- Pages
- 5305-5308
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1500990165
- Cited by
- 333
- References
- 0
- FWCI
- 27.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kasuga, M., Van Obberghen, E., Nissley, S. P., & Rechler, M. M. (1981). Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)69196-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
