The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.
Open accessAbstract
Rat hepatoma cells were labeled with [32P]orthophosphate and the insulin receptor subunits were identified by immunoprecipitation and sodium dodecyl sulfate-acrylamide gel electrophoresis. In the basal state, only the Mr = 95,000 (beta) subunit of the insulin receptor was phosphorylated. The covalent labeling with 32P of this subunit was stimulated about 3-fold by insulin (10(-6) M). This stimulation was due to an increase in the content of phosphoserine, the appearance of phosphotyrosine, and a possible increase in phosphothreonine as well. These results suggest phosphorylation of the insulin receptor at multiple sites is an early event in insulin action.
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Cites
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Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor
Kasuga, M., Karlsson, F. A., & Kahn, C. R. (1982) · Science · doi:10.1126/science.7031900 · Cited by 1,126
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Cited by
Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947
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The structure of 2Zn pig insulin crystals at 1.5 Å resolution
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The Molecular Basis for Oxidative Stress-Induced Insulin Resistance
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Metadata
- Authors
- Kasuga, M., Zick, Y., Blith, D. L., Karlsson, F. A., Häring, H. U., & Kahn, C. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1982-09
- Volume
- 257
- Issue
- 17
- Pages
- 9891-9894
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1538276446
- Cited by
- 437
- References
- 23
- FWCI
- 24.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. https://app.cochat.ai/papers/10.1016/s0021-9258(18)33955-3
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- Kasuga, M., Zick, Y., Blith, D. L., Karlsson, F. A., Häring, H. U., & Kahn, C. R. (1982). Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)33955-3
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
