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Cited by 386

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development.

Open access
McMorris, F A, Smith, T M, DeSalvo, S, Furlanetto, R W·1986·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.83.3.822
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Abstract

Cell cultures established from cerebrum of 1-day-old rats were used to investigate hormonal regulation of the development of oligodendrocytes, which synthesize myelin in the central nervous system. The number of oligodendrocytes that developed was preferentially increased by insulin, or by insulin-like growth factor I (IGF-I), also known as somatomedin C. High concentrations (5 micrograms/ml) of insulin were required for substantial induction of oligodendrocyte development, whereas only 3.3 ng of IGF-I per ml was needed for a 2-fold increase in oligodendrocyte numbers. At an IGF-I concentration of 100 ng/ml, oligodendrocyte numbers were increased 6-fold in cultures grown in the presence of 10% fetal bovine serum, or up to 60-fold in cultures maintained in serum-free medium. IGF-I produced less than a 2-fold increase in the number of nonoligodendroglial cells in the same cultures. Type I IGF receptors were identified on oligodendrocytes and on a putative oligodendrocyte precursor cell population identified by using mouse monoclonal antibody A2B5. These results indicate that IGF-I is a potent inducer of oligodendrocyte development and suggest a possible mechanism based on IGF deficiency for the hypomyelination that results from early postnatal malnutrition.

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Metadata

Authors
McMorris, F. A., Smith, T. M., DeSalvo, S., & Furlanetto, R. W.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1986-02
Volume
83
Issue
3
Pages
822-826
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.83.3.822
OpenAlex
W2005272267
Cited by
386
References
33
FWCI
8.88
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development. https://app.cochat.ai/papers/10.1073/pnas.83.3.822
The paper
McMorris, F. A., Smith, T. M., DeSalvo, S., & Furlanetto, R. W. (1986). Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.3.822

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.