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Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.
Open accessAbstract
Osteogenic protein-2, OP-2, a new member of the transforming growth factor-beta (TGF-beta) superfamily, closely related to the osteogenic/bone morphogenetic proteins, was discovered in mouse embryo and human hippocampus cDNA libraries. The TGF-beta domain of OP-2 shows 74% identity to OP-1, 75% to Vgr-1, and 76% to BMP-5, hence OP-2 may also have bone inductive activity. The genomic locus of OP-2 has seven exons, like OP-1, and spans more than 27 kilobases (kb). In the C-terminal TGF-beta domain, OP-2 has a unique additional cysteine. Mouse embryos express relatively high levels of OP-2 mRNA at 8 days, two species of 3 and 5 kb. A careful study of mRNA expression of the osteogenic proteins in specific organs revealed discrete mRNA species for BMP-3, BMP-4, BMP-5, and BMP-6/Vgr-1 in lung or liver of young and adult mice. OP-1 is expressed in kidney; however, OP-2 and BMP-2 mRNAs were not detected in any organs studied, suggesting an early developmental role.
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Cited by
Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily
Storm, E. E., Huynh, T. V., Copeland, N. G., Jenkins, N. A., Kingsley, D. M., & Lee, S.-J. (1994) · Nature · doi:10.1038/368639a0 · Cited by 854
What do BMPs do in mammals? Clues from the mouse short-ear mutation
Kingsley, D. M. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90014-0 · Cited by 295
Periodontal tissue engineering by growth factors
Giannobile, W. V. (1996) · Bone · doi:10.1016/s8756-3282(96)00127-5 · Cited by 295
Nakashima, M. (1994) · Journal of Dental Research · doi:10.1177/00220345940730090601 · Cited by 275
Adamska, M., Degnan, S. M., Green, K. M., Adamski, M., Craigie, A., Larroux, C., & Degnan, B. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001031 · Cited by 257
Metadata
- Authors
- Ozkaynak, E., Schnegelsberg, P. N., Jin, D. F., Clifford, G. M., Warren, F. D., Drier, E. A., & Oppermann, H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-12
- Volume
- 267
- Issue
- 35
- Pages
- 25220-25227
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2168905766
- Cited by
- 265
- References
- 0
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ozkaynak, E., Schnegelsberg, P. N., Jin, D. F., Clifford, G. M., Warren, F. D., Drier, E. A., & Oppermann, H. (1992). Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)74028-9
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