The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Induction of Dentin Formation on Canine Amputated Pulp by Recombinant Human Bone Morphogenetic Proteins (BMP)-2 and -4
Abstract
Dental pulp cells have the potential to differentiate into odontoblasts. The molecular mechanisms underlying differentiation are not clear. Demineralized dentin matrix is osteoinductive and contains bone morphogenetic protein (BMP) activity. BMPs have been implicated in embryonic odontogenic differentiation and hence may play a role in the differentiation of adult pulp cells into odontoblasts during pulpal healing. This study examined the hypothesis that BMPs induce dentin formation on amputated canine pulp. Recombinant human BMP-2 and BMP-4 were capped with inactivated dentin matrix on amputated pulp. At two months, the amputated pulp was filled with tubular dentin in the lower part and osteodentin in the upper part. The amount of dentin formed was markedly diminished when dentin matrix alone was implanted. These findings imply that recombinant human BMP-2 and BMP-4 induce differentiation of adult pulp cells into odontoblasts. Thus, BMPs may have a role in dentistry as a bioactive pulp-capping agent to induce dentin formation.
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Cites
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Recombinant human bone morphogenetic protein induces bone formation.
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OP-1 cDNA encodes an osteogenic protein in the TGF-beta family.
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Cited by
Bessa, P. C., Casal, M., & Reis, R. L. (2008) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.74 · Cited by 549
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The Application of Tissue Engineering to Regeneration of Pulp and Dentin in Endodontics
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Metadata
- Authors
- Nakashima, M.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 1994-09
- Volume
- 73
- Issue
- 9
- Pages
- 1515-1522
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W1848208109
- Cited by
- 275
- References
- 21
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Induction of Dentin Formation on Canine Amputated Pulp by Recombinant Human Bone Morphogenetic Proteins (BMP)-2 and -4. https://app.cochat.ai/papers/10.1177/00220345940730090601
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- Nakashima, M. (1994). Induction of Dentin Formation on Canine Amputated Pulp by Recombinant Human Bone Morphogenetic Proteins (BMP)-2 and -4. Journal of Dental Research. https://doi.org/10.1177/00220345940730090601
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
