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The function of catalase-bound NADPH.
Open accessAbstract
Catalase (H2O2:H2O2 oxidoreductase, EC 1.11.1.6) is of historical interest for having been the subject of some of the earliest investigations of enzymes. A feature of catalase that has been poorly understood for several decades, however, is the mechanism by which catalase remains active in the presence of its own substrate, hydrogen peroxide. We reported recently that catalase contains tightly bound NADPH. The present study with bovine and human catalase revealed that NADPH both prevents and reverses the accumulation of compound II, an inactive form of catalase that is generated slowly when catalase is exposed to hydrogen peroxide. Since the effect of NADPH occurs even at NADPH concentrations below 0.1 microM, the protective mechanism is likely to operate in vivo. This discovery of the role of catalase-bound NADPH brings a unity to the concept of two different mechanisms for disposing of hydrogen peroxide (catalase and the glutathione reductase/peroxidase pathway) by revealing that both mechanisms are dependent on NADPH.
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Citations
Cites
Glutathione Peroxidase: The Primary Agent for the Elimination of Hydrogen Peroxide in Erythrocytes*
Cohen, G., & Hochstein, P. (1963) · Biochemistry · doi:10.1021/bi00906a038 · Cited by 666
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Velikova, V, Yordanov, I., & Edreva, A. (2000) · Plant Science · doi:10.1016/s0168-9452(99)00197-1 · Cited by 5,299
Antioxidants in health and disease
Young, I. S., & Woodside, J. V. (2001) · Journal of Clinical Pathology · doi:10.1136/jcp.54.3.176 · Cited by 1,949
Intracellular Antioxidants: from Chemical to Biochemical Mechanisms
Chaudière, J., & Ferrari-Iliou, R. (1999) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(99)00090-3 · Cited by 671
Willekens, H., Inzé, D., Van Montagu, M., & van Camp, W. (1995) · Molecular Breeding · doi:10.1007/bf02277422 · Cited by 451
Predominant role of catalase in the disposal of hydrogen peroxide within human erythrocytes
Gaetani, G., Ferraris, A., Rolfo, M., Mangerini, R., Arena, S., & Kirkman, H. (1996) · Blood · doi:10.1182/blood.v87.4.1595.bloodjournal8741595 · Cited by 296
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Metadata
- Authors
- Kirkman, H. N., Galiano, S., & Gaetani, G. F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1987-01
- Volume
- 262
- Issue
- 2
- Pages
- 660-666
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1585735064
- Cited by
- 289
- References
- 1
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kirkman, H. N., Galiano, S., & Gaetani, G. F. (1987). The function of catalase-bound NADPH. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)75835-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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