The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Studies on Squalene Epoxidase of Rat Liver
Open accessAbstract
Rat liver microsomes previously heated to 50" for 5 mm accumulate 2,3-oxidosqualene on incubation with squalene.Squalene epoxidase activity can be assayed either with squalene and heated microsomes or with lO,ll-dihydrosqualene and intact microsomes.In common with other monooxygenases, the epoxidase requires TPNH and molecular oxygen.Both a soluble fraction of rat liver and microsomes are necessary for enzyme activity.Carbon monoxide or potassium cyanide fall to inhibit squalene epoxidation.
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“Cholesterol homeostasis is maintained by negative feedback regulation of genes and their encoded enzymes in the pathway, including the rate limiting enzymes HMG CoA reductase (HMGCR) and SQLE20–22.”
From A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome (2013) · cites this paper as [22]
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Evidence for Biochemically Different Types of Vesicles in the Hepatic Microsomal Fraction*
Imai, Y., Ito, A., & Sato, R. (1966) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a128453 · Cited by 749
Eschenmoser, A., Růžička, L., Jeger, O., & Arigoni, D. (1955) · Helvetica Chimica Acta · doi:10.1002/hlca.19550380728 · Cited by 605
Mechanisms of Oxygen Metabolism
Mason, H. S. (1957) · Science · doi:10.1126/science.125.3259.1185 · Cited by 313
Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes
Oshino, N., Imai, Y., & Sato, R. (1966) · Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation · doi:10.1016/0926-6593(66)90137-8 · Cited by 285
Mason, H. S. (1965) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.34.070165.003115 · Cited by 238
2,3-Oxidosqualene, an Intermediate in the Biological Synthesis of Sterols from Squalene1
Corey, E. J., Russey, W. E., & de Montellano, P. R. O. (1966) · Journal of the American Chemical Society · doi:10.1021/ja00972a056 · Cited by 225
Enzymic Conversion of Squalene 2,3-Oxide to Lanosterol and Cholesterol
Tamelen, E. E. V., Willett, J. D., Clayton, R. B., & Lord, K. E. (1966) · Journal of the American Chemical Society · doi:10.1021/ja00972a058 · Cited by 177
Studies on the Biosynthesis of Cholesterol
Popják, G. J., Goodman, D. S., Cornforth, J. W., Cornforth, R. H., & Ryhage, R. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64109-2 · Cited by 166
ON THE CONVERSION OF SQUALENE TO LANOSTEROL IN VITRO
Tchen, T. T., & Bloch, K. E. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70878-8 · Cited by 136
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Research works printed but not linked: 2
- Hayaishi, 1964, 83, 31
- Scallen, 1969, Fed. Proc., 28, 665
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Epoxides in Polycyclic Aromatic Hydrocarbon Metabolism and Carcinogenesis
Sims, P. H., & Grover, P. L. (1974) · Advances in cancer research · doi:10.1016/s0065-230x(08)60111-6 · Cited by 724
Garner, R. C., Miller, E. C., & MILLER, J. A. (1972) · PubMed · Cited by 410
Biochemistry of the violaxanthin cycle in higher plants
Yamamoto, H. Y. (1979) · Pure and Applied Chemistry · doi:10.1351/pac197951030639 · Cited by 372
Rose, K., & Steinbüchel, A. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.6.2803-2812.2005 · Cited by 308
Gill, S., Stevenson, J., Kristiana, I., & Brown, A. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.015 · Cited by 304
Metadata
- Authors
- Yamamoto, S., & Bloch, K.
- Affiliations
- Harvard University (US)
- ORCID
- Bloch, Konrad
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1970-04
- Volume
- 245
- Issue
- 7
- Pages
- 1670-1674
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1606948338
- Cited by
- 163
- References
- 18
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- squalene epoxidase, squalene epoxidation, 2,3-oxidosqualene, liver microsomes, mixed function oxidase, molecular oxygen, enzyme inhibition, carbon monoxide, potassium cyanide, rat liver
- MeSH terms
- Alkenes, Animals, Carbon Isotopes, Carbon Monoxide, Chelating Agents, Cholestanes, Chromatography, Thin Layer, Cyanides, Ethers, Cyclic, Fatty Acids, Female, Lipoproteins, Liver, Microsomes, Liver, Oxygenases, Solubility, Squalene, Temperature, Transferases, Tritium, Rats
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