Cited by 163Plant biochemistry and biosynthesisPharmacogenetics and Drug MetabolismCholesterol and Lipid Metabolism

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Studies on Squalene Epoxidase of Rat Liver

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Yamamoto, Shozo, Bloch, Konrad·1970·Journal of Biological Chemistry

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Abstract

Rat liver microsomes previously heated to 50" for 5 mm accumulate 2,3-oxidosqualene on incubation with squalene.Squalene epoxidase activity can be assayed either with squalene and heated microsomes or with lO,ll-dihydrosqualene and intact microsomes.In common with other monooxygenases, the epoxidase requires TPNH and molecular oxygen.Both a soluble fraction of rat liver and microsomes are necessary for enzyme activity.Carbon monoxide or potassium cyanide fall to inhibit squalene epoxidation.

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Authors: Yamamoto, S., & Bloch, K.
Affiliations: Harvard University (US)
ORCID: Bloch, Konrad
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1970-04
Volume: 245
Issue: 7
Pages: 1670-1674
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(19)77144-0
OpenAlex: W1606948338
Cited by: 163
References: 18
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 3
FWCI: 2.98
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 18479 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: squalene epoxidase, squalene epoxidation, 2,3-oxidosqualene, liver microsomes, mixed function oxidase, molecular oxygen, enzyme inhibition, carbon monoxide, potassium cyanide, rat liver
MeSH terms: Alkenes, Animals, Carbon Isotopes, Carbon Monoxide, Chelating Agents, Cholestanes, Chromatography, Thin Layer, Cyanides, Ethers, Cyclic, Fatty Acids, Female, Lipoproteins, Liver, Microsomes, Liver, Oxygenases, Solubility, Squalene, Temperature, Transferases, Tritium, Rats

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Studies on Squalene Epoxidase of Rat Liver

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