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EFFECT OF HYPERGLYCEMIC-GLYCOGENOLYTIC FACTOR AND EPINEPHRINE ON LIVER PHOSPHORYLASE
Open accessAbstract
The hyperglycemic-glycogenolytic (H-G) factor, a protein originating in the islet tissue of the pancreas (l-3), and various sympathomimetic amines, of which epinephrine is the chief representative, cause increased hepatic glycogenolysis in viva and in vitro. The glucose output of rabbit liver slices has been used as a quantitative test system for the action of these glycogenolytic agents in vitro. Since there are only three enzymatic reactions involved in the formation of blood sugar in the liver, there was some hope of finding out which of these was the primary point of action. It will be shown in this paper that the first step, the phosphorylase reaction, is rate-limiting and that the H-G factor and epinephrine exert their effect by causing a rapid increase in the phosphorylase activity of the liver.
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Citations
Cited by
Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)
SUTHERLAND, E. W., ROBISON, G. A., & BUTCHER, R. W. (1968) · Circulation · doi:10.1161/01.cir.37.2.279 · Cited by 965
Self-citationRegulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro
Coore, H., & Randle, P. (1964) · Biochemical Journal · doi:10.1042/bj0930066 · Cited by 540
Shen, S.-W., Reaven, G. M., & Farquhar, J. W. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106433 · Cited by 494
Etiological Status and Associated Studies of Pale, Soft, Exudative Porcine Musculature
Briskey, E. J. (1964) · Advances in Food Research · doi:10.1016/s0065-2628(08)60100-7 · Cited by 398
STUDIES ON THE MECHANISM OF ACTION OF THE ADRENOCORTICOTROPIC HORMONE
Haynes, R. C., & Berthet, L. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64914-2 · Cited by 332
Metadata
- Authors
- Sutherland, E. W., & Cori, C. F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1951-02
- Volume
- 188
- Issue
- 2
- Pages
- 531-543
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W172580750
- Cited by
- 249
- References
- 0
- FWCI
- 21.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: EFFECT OF HYPERGLYCEMIC-GLYCOGENOLYTIC FACTOR AND EPINEPHRINE ON LIVER PHOSPHORYLASE. https://app.cochat.ai/papers/10.1016/s0021-9258(19)77725-4
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- Sutherland, E. W., & Cori, C. F. (1951). EFFECT OF HYPERGLYCEMIC-GLYCOGENOLYTIC FACTOR AND EPINEPHRINE ON LIVER PHOSPHORYLASE. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)77725-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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