The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Effect of cadmium on estrogen receptor levels and estrogen-induced responses in human breast cancer cells
Open accessAbstract
The effects of cadmium on estrogen receptor and other estrogen-regulated genes in the human breast cancer cell line MCF-7 were studied. Treatment of MCF-7 cells with 1 microM cadmium decreased the level of estrogen receptor 58%. Cadmium induced a parallel decrease in estrogen receptor mRNA (62%). Progesterone receptor levels increased 3.2-fold after cadmium treatment. This induction was blocked by the anti-estrogen ICI-164,384. Progesterone receptor mRNA was also increased by cadmium, as well as cathepsin D mRNA. An in vitro nuclear transcription run-on assay showed that cadmium increased the transcription of the progesterone receptor and pS2 genes and decreased transcription of the estrogen receptor gene. These are not general effects of heavy metals, as zinc, 25 and 100 microM, did not affect progesterone receptor protein and mRNA levels. Cadmium stimulated pS2 and progesterone receptor mRNAs in a clone of MDA-MB-231 cells transfected with the human estrogen receptor, but had no effect in MDA-MB-231 cells transfected with antisense estrogen receptor. Cadmium also stimulated an estrogen response element in transient transfection experiments. These data suggest that the effects of cadmium are mediated by the estrogen receptor independent of estradiol. In addition to its effect on gene expression, cadmium induced the growth of MCF-7 cells 5.6-fold.
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Cites
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Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line
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Self-citationOestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor
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A new, nongenomic estrogen action: the rapid release of intracellular calcium
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Current status of cadmium as an environmental health problem
Järup, L., & Åkesson, A. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.04.020 · Cited by 2,355
Environmental Signaling: What Embryos and Evolution Teach Us About Endocrine Disrupting Chemicals
McLachlan, J. A. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.3.0432 · Cited by 608
The Effects of Metals as Endocrine Disruptors
Iavicoli, I., Fontana, L., & Bergamaschi, A. (2009) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400902902062 · Cited by 486
Estrogen-Like Activity of Metals in Mcf-7 Breast Cancer Cells
Martin, M. B., Reiter, R., Pham, T., Avellanet, Y. R., Camara, J., Lahm, M., Pentecost, E., Pratap, K., Gilmore, B. A., Divekar, S., et al. (2003) · Endocrinology · doi:10.1210/en.2002-221054 · Cited by 409
Self-citationActivation of estrogen receptor-α by the anion nitrite
Veselik, D. J., Divekar, S., Dakshanamurthy, S., Storchan, G. B., Turner, J. M. A., Graham, K. L., Huang, L., Stoica, A., & Martin, M. B. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2783 · Cited by 42
Self-citation
Metadata
- Authors
- Garcia-Morales, P., Saceda, M., Kenney, N., Kim, N., Salomon, D. S., Gottardis, M. M., Solomon, H. B., Sholler, P. F., Jordan, V. C., & Martin, M. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-06
- Volume
- 269
- Issue
- 24
- Pages
- 16896-16901
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1479965447
- Cited by
- 324
- References
- 32
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Garcia-Morales, P., Saceda, M., Kenney, N., Kim, N., Salomon, D. S., Gottardis, M. M., Solomon, H. B., Sholler, P. F., Jordan, V. C., & Martin, M. B. (1994). Effect of cadmium on estrogen receptor levels and estrogen-induced responses in human breast cancer cells. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)89474-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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