The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis
Open accessAbstract
During the last three years there have been a plethora of publications on the liver X-activated receptors (LXRalpha, NR1H3, and LXRbeta, NR1H2), the farnesoid X-activated receptor (FXR, NR1H4), and the pregnane X receptor (PXR, NR1I2) and the role these nuclear receptors play in controlling cholesterol, bile acid, lipoprotein and drug metabolism. The current interest in these nuclear receptors is high, in part, because they appear to be promising therapeutic targets for new drugs that have the potential to control lipid homeostasis. In this review we emphasize i) the role of LXR in controlling many aspects of cholesterol and fatty acid metabolism, ii) the expanded role of FXR in regulating genes that control not only bile acid metabolism but also lipoprotein metabolism, and iii) the regulation of bile acid transport/metabolism in response to bile acid-activated PXR.
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Cites
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Cited by
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
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Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
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Metadata
- Authors
- Edwards, P. A., Kast, H. R., & Anisfeld, A. M.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 43
- Issue
- 1
- Pages
- 2-12
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W1962935964
- Cited by
- 385
- References
- 11
- FWCI
- 41.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. https://app.cochat.ai/papers/10.1016/s0022-2275(20)30180-2
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- Edwards, P. A., Kast, H. R., & Anisfeld, A. M. (2002). BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)30180-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
