Apolipoprotein E metabolism in normolipoproteinemic human subjects.
Open accessAbstract
Human apolipoprotein E (apoE) is a constituent of plasma very low density and high density lipoproteins and is important in modulating the catabolism of remnants of triglyceride-rich lipoproteins. There are three common isoforms of apoE, designated apoE-2, E-3, and E-4, which are coded by three separate alleles (epsilon 2, epsilon 3, and epsilon 4) at a single genetic locus and inherited in the population in a co-dominant fashion. ApoE-3 is the predominant apoE isoform in the normolipidemic population, and epsilon 3 has been proposed to be the normal allele. ApoE-3 metabolism was studied in nine normolipidemic subjects homozygous for the epsilon 3 allele. In these subjects, the plasma apoE-3 concentration was 4.8 +/- 1.2 mg/dl (mean +/- SD), the plasma apoE-3 residence time was 0.73 +/- 0.18 days, and the plasma apoE-3 production rate was 3.4 +/- 1.5 mg/kg-day. The apoE in males, when compared to females, tended to have a shorter residence time (0.63 +/- 0.15 days versus 0.83 +/- 0.16), a higher production rate (4.20 +/- 1.73 mg/kg-days versus 2.60 +/- 0.78), but a similar plasma concentration (5.1 +/- 1.5 mg/dl versus 4.5 +/- 0.8). ApoE-3 had a more rapid catabolism from plasma than other apolipoproteins previously studied (apolipoproteins A-I, A-II, A-IV, B-100, C-II, and C-III) except for apolipoprotein B-48. The catabolism of apoE-3 in the individual lipoprotein subfractions was also examined and apoE was shown to be catabolized most rapidly from the VLDL and slowest from…
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Apo E3 is the most common form in the population and is regarded as the parent or normal isoform.
“As apo E3 is the most common form in the population (28, 45, 47), it is regarded as the parent (24) or normal isoform (48).”
From Apolipoprotein E2-Christchurch (136 Arg----Ser). New variant of human apolipoprotein E in a patient with type III hyperlipoproteinemia. (1987) · cites this paper as [48]
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- Authors
- Gregg, R., Zech, L., Schaefer, E., & Brewer, H.
- Affiliations
- Tufts University (US)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1984-11
- Volume
- 25
- Issue
- 11
- Pages
- 1167-1176
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2114955079
- Cited by
- 90
- References
- 3
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 1 · 2017: 1 · 2013: 1 · 2012: 3
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- apolipoprotein E, APOE isoforms, APOE ε4, sex differences, lipoprotein subfractions, VLDL, HDL cholesterol, normolipidemic subjects
- MeSH terms
- Adult, Apolipoproteins E, Energy Intake, Female, Humans, Iodine Radioisotopes, Kinetics, Lipoproteins, VLDL, Male, Phenotype, Plasma Volume, Reference Values, Sex Factors
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