Increased dietary triacylglycerol markedly enhances the ability of isolated rabbit enterocytes to secrete chylomicrons: an effect related to dietary fatty acid composition
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Dietary fats are efficiently absorbed in the small intestine and transported into the blood via the lymph as chylomicrons, despite enormous variations in the amount and composition of the dietary lipid. The aim of the present study was to investigate how enterocytes respond to increased dietary fats of different composition. Rabbits were fed a low fat chow diet, and chow supplemented with sunflower oil (high n-6 polyunsaturated fatty acids), fish oil (high n-3 polyunsaturated fatty acids), or an oil mixture of a composition similar to that of the typical western diet. Feeding fat for 2 weeks markedly stimulated the ability of the isolated enterocytes to synthesize and secrete apolipoprotein B48, triacylglycerol, and cholesteryl ester (up to 18-, 50-, and 80-fold, respectively) in particles of chylomicron density. The magnitude of stimulation was sunflower oil > western diet lipid > fish oil. Single doses of lipid given 18 h prior to isolation of enterocytes stimulated chylomicron secretion by only 10% of that observed after 2 weeks of dietary supplementation. Enterocytes are replaced rapidly (half-life 1-2 days) by cells which move from the crypts to the tips of the villi, where absorption of nutrients takes place. Our observations suggest that dietary lipids modulate the function of enterocytes as they move from the crypts, so that the cells are 'turned-on' to lipid absorption. The results also show that diets of different fatty acid composition vary in their effects.
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Fish oil feeding did not slow TG absorption or chylomicron secretion in rats or secretion from rabbit enterocytes ex vivo.
“Fish oil feeding did not slow TG absorption or chylomicron secretion in rats (32) or secretion from rabbit enterocytes ex vivo (42).”
From Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance (2003) · cites this paper as [42]
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- Authors
- Cartwright, I. J., & Higgins, J. A.
- Affiliations
- University of Sheffield (GB)
- Corresponding author
- Higgins, Joan A.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 40
- Issue
- 10
- Pages
- 1858-1866
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2186596263
- Cited by
- 43
- References
- 37
- Citations by year
- 2025: 1 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 6
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- chylomicron secretion, enterocytes, dietary fatty acid composition, apolipoprotein B-48, cholesterol esters, sunflower oil, fish oil, Western diet, fat absorption, intestinal lipid transport, rabbits
- MeSH terms
- Sunflower Oil, Animals, Apolipoproteins B, Cholesterol Esters, Chylomicrons, Dietary Fats, Fatty Acids, Unsaturated, Fish Oils, Humans, Kinetics, Plant Oils, Rabbits, Regression Analysis, Triglycerides, Fatty Acids, Omega-3, Enterocytes, Fatty Acids, Omega-6, Apolipoprotein B-48
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