Motor and cognitive development in children with congenital hypothyroidism: a long-term evaluation of the effects of neonatal treatment
Abstract
Although neonatal thyroid screening programs have been of value in preventing cerebral damage, it is still controversial whether patients with congenital hypothyroidism achieve normal motor and cognitive skills. We studied the motor and cognitive skills of 72 children with early-treated congenital hypothyroidism and 35 control subjects at the ages of 7 1/2 and 9 1/2 years. The relative influence of cause, blood thyroxine concentration at the time of screening, and age at the start of thyroxine replacement therapy on motor and cognitive development was investigated. Despite having received treatment at a mean age of 23 days, children with low neonatal thyroxine concentrations (< 50 nmol/L) at screening, particularly children with thyroid agenesis, had significant motor problems and borderline intelligence scores as late as 9 1/2 years of age. Balance and gross motor functions seemed to decline between 7 1/2 and 9 1/2 years of age, whereas language and memory functions seemed to be maintained. Significant correlations between the start of therapy and both motor scores and performance IQ scores at the age of 7 1/2 years in children with severe hypothyroidism show the importance of early treatment for these patients.
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Previous studies in patients with primary congenital hypothyroidism have shown a relationship between pretreatment (F)T4 and FSIQ or obtained educational level.
“Previous studies in patients with primary CH have shown a relationship between pretreatment (F)T4, and FSIQ or obtained educational level (23-25).”
From Cognitive and Motor Outcome in Patients with Early-Detected Central Congenital Hypothyroidism Compared with Siblings (2021) · cites this paper as [23]
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Naafs, J. C., Marchal, J. P., Fliers, E., Verkerk, P. H., Luijten, M. A. J., Boelen, A., van Trotsenburg, A. S. P., & Zwaveling-Soonawala, N. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa901 · Cited by 21 · see citing works
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- Authors
- Kooistra, L., Laane, C., Vulsma, T., Schellekens, J. M. H., van der Meere, J. J., & Kalverboer, A. F.
- Affiliations
- University of Groningen (NL)
- Corresponding author
- Kooistra, Libbe
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 1994-06
- Volume
- 124
- Issue
- 6
- Pages
- 903-909
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2061534287
- Cited by
- 185
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 1 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- congenital hypothyroidism, neonatal thyroid screening, thyroxine replacement, motor development, cognitive development, thyroid agenesis, age at treatment initiation, balance, gross motor function, language, memory, intelligence quotient, early treatment
- MeSH terms
- Age Factors, Child, Child Development, Cognition, Congenital Hypothyroidism, Female, Humans, Hypothyroidism, Longitudinal Studies, Male, Motor Skills, Thyroxine
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