The DOI matches its Crossref record; 4 of the 6 references it cites were found in a registry or an index.
Growth rebound after termination of stimulant drugs
Abstract
To explore further the report of an accelerated weight gain following termination of treatment with a stimulant drug, 66 biannual growth measurements were obtained from 1970 to 1973 on hyperactive schoolchildren who were receiving medication. All received either dextroamphetamine or methylphenidate during the school year; some also received it during the summer. The data revealed that those whose stimulant medication was terminated at the start of summer subsequently grew in weight and height at a significantly greater rate than those who continued to receive medication from June to September. In fact, discontinuance of the medication resulted in a growth rebound for this period which was 15-68% above the age-expected increment.
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“the use of summer (or periodic) holidays, which represent relatively long intervals of nontreatment interspersed within blocks of medication use in clinical practice, has been proposed as a strategy to mitigate stimulant-related reductions in growth rates (Safer et al., 1975)”
From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Safer et al., 1975
Citations
Cites
Nelson, W. E. (1960) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(60)90543-3 · Cited by 1,385
Depression of Growth in Hyperactive Children on Stimulant Drugs
Safer, D. J., Allen, R. P., & Barr, E. (1972) · New England Journal of Medicine · doi:10.1056/nejm197208032870503 · Cited by 248
Safer, D. J., & Allen, R. P. (1973) · PEDIATRICS · doi:10.1542/peds.51.4.660 · Cited by 158
Schor, S. S. (1965) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-196501000-00013 · Cited by 3
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Items 101–123 of 123
Long-Term Stimulant Effects in Children with Attention Deficit Hyperactivity Disorder (ADHD)
Hechtman, L. T. (2004) · Child and Adolescent Psychopharmacology News · doi:10.1521/capn.9.1.1.31010 · Cited by 1
The differentiation and treatment of two patterns of hyperkinesis in the classroom
Williamson, G. A. (1978) · ThinkTech (Texas Tech University) · Cited by 1
Drug-Induced Changes to Nutritional Status
Gervasio, J. M. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-781-9_13 · Cited by 1
Hyperkinesis and Attentional Deficiencies
Chess, S., & Hassibi, M. (1978) · Springer eBooks · doi:10.1007/978-1-4899-2198-7_17
Central nervous system stimulants and anorectic agents
Connell, P. H. (1977) · Side effects of drugs annual · doi:10.1016/s0378-6080(77)80004-4
Hyperactivity: Pediatricians’ and Teachers’ Perspectives
Kalechstein, M., Hansen, P., & Kalechstein, P. B. W. (1979) · Journal of School Health · doi:10.1111/j.1746-1561.1979.tb05272.x
Methylphenidate (Ritalin) and Growth Hormone Secretion
AvRuskin, T. W. (1979) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1979.02130050097022
Yeom, C., Eun, T. K., Park, H.-S., Lee, K. Y., Kim, E.-J., Joo, E.-J., & Koo, Y.-J. (2014) · Journal of korean Academy of Child and Adolescent Psychiatry · doi:10.5765/jkacap.2014.25.2.89 · Cited by 4
Use of drugs in child psychiatry
Sitholey, P. (1984) · The Indian Journal of Pediatrics · doi:10.1007/bf02776435
Deficiencias nutricionales inducidas por fármacos
Felipez, L. M., & Sentongo, T. A. S. (2009) · Clínicas pediátricas de Norteamérica
Laski, P., Gorney, E., Finkle, L. J., & Dougherty, C. (1975)
Stimulants in ADHD: Effects on Weight and Height
Elliott, G. R. (2007) · Medical psychiatry · doi:10.3109/9781420017144.028
Evidence-based pharmacotherapy of attention deficit hyperactivity disorder
Vaughan, B. S., March, J. S., & Kratochvil, C. J. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511910395.002
Dyslexia and other reading problems: An optometric perspective
Cao, H. K., & Fenno, C. M. (1986) · CommonKnowledge Research Repository (Pacific University Oregon)
Posner, J. E., Greenhill, L. L., & Nelson, J. C. (2015) · Wiley eBooks · doi:10.1002/9781118753378.ch108
Martin, J. E., & Agran, M. (1988) · Applied clinical psychology · doi:10.1007/978-1-4613-0983-3_6
Safer, D. J., & Allen, R. P. (1975) · The Journal of Pediatrics · doi:10.1016/s0022-3476(75)80620-2
Hyperkinesis and Attentional Deficiencies
Chess, S., & Hassibi, M. (1986) · Springer eBooks · doi:10.1007/978-1-4613-2145-3_17
(2015) · Elsevier eBooks · doi:10.1016/b978-0-444-53717-1.01067-2
(2006) · Elsevier eBooks · doi:10.1016/b0-44-451005-2/00021-8
Fenton, C., & Lee, A. (2022) · Drugs & Therapy Perspectives · doi:10.1007/s40267-022-00921-x · Cited by 2
Gabbay, M., Gabbay, U., & Carmi, D. (2026) · Pediatric Research · doi:10.1038/s41390-026-04929-1
Posner, K., Pressman, A. W., & Greenhill, L. L. (2010) · Elsevier eBooks · doi:10.1016/b978-84-458-2021-6.00003-8
Metadata
- Authors
- Safer, D. J., Allen, R. P., & Barr, E.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Safer, Daniel J.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 1975-01
- Volume
- 86
- Issue
- 1
- Pages
- 113-116
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2040914596
- Cited by
- 123
- References
- 6
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 3 · 2019: 1 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 6
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- d-amphetamine, methylphenidate, hyperactive children, weight gain, height growth, ADHD medication
- MeSH terms
- Adolescent, Body Height, Body Weight, Child, Dextroamphetamine, Female, Humans, Hyperkinesis, Male, Methylphenidate
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