Cited by 123Attention Deficit Hyperactivity DisorderPharmacology and Obesity TreatmentPharmaceutical studies and practices

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Growth rebound after termination of stimulant drugs

Safer, Daniel J., Allen, Richard P., Barr, Evelyn·1975·The Journal of Pediatrics

DOI 10.1016/s0022-3476(75)80720-7

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Abstract

To explore further the report of an accelerated weight gain following termination of treatment with a stimulant drug, 66 biannual growth measurements were obtained from 1970 to 1973 on hyperactive schoolchildren who were receiving medication. All received either dextroamphetamine or methylphenidate during the school year; some also received it during the summer. The data revealed that those whose stimulant medication was terminated at the start of summer subsequently grew in weight and height at a significantly greater rate than those who continued to receive medication from June to September. In fact, discontinuance of the medication resulted in a growth rebound for this period which was 15-68% above the age-expected increment.

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Authors: Safer, D. J., Allen, R. P., & Barr, E.
Affiliations: Johns Hopkins University (US)
Corresponding author: Safer, Daniel J.
ORCID: Safer, Daniel J.
Allen, Richard P.
Venue: The Journal of Pediatrics
Publisher: Elsevier BV
Published: 1975-01
Volume: 86
Issue: 1
Pages: 113-116
ISSN: 0022-3476 (ISSN-L)
DOI: 10.1016/s0022-3476(75)80720-7
OpenAlex: W2040914596
Cited by: 123
References: 6
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 3 · 2019: 1 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 6
FWCI: 10.44
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Pediatrics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords: d-amphetamine, methylphenidate, hyperactive children, weight gain, height growth, ADHD medication
MeSH terms: Adolescent, Body Height, Body Weight, Child, Dextroamphetamine, Female, Humans, Hyperkinesis, Male, Methylphenidate

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