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Cited by 156Attention Deficit Hyperactivity DisorderPharmaceutical studies and practicesNeuroethics, Human Enhancement, Biomedical Innovations

Methylphenidate and Growth in Hyperactive Children: A Controlled Withdrawal Study

Klein, Rachel Gittelman·1988·Archives of General Psychiatry
DOI 10.1001/archpsyc.1988.01800360075011
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Abstract

The effect of stimulants on growth has been controversial. Among hyperactive children receiving long-term methylphenidate hydrochloride treatment, we examined the effects of methylphenidate withdrawal on the growth of hyperactive children randomly assigned to be taken off, or remain on, the medication regimen over two consecutive summers. After one summer, no group difference in height was found, but weight was higher in the group that had been taken off methylphenidate therapy. In contrast, two summers of being off methylphenidate treatment had a significant positive effect on height but not on weight. The results document a linkage between exposure to methylphenidate and reduction in growth velocity. However, they do not address whether the medication has long-term effects on height.

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Crossref · 10.1001/archpsyc.1988.01800360075011

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  • Current data indicate that the initial effect of stimulants on growth appears to attenuate over time, and early studies of adult outcomes of children treated with stimulant medications have suggested that final adult height is not affected.

    “Current data indicate that the initial effect of stimulants on growth appears to attenuate over time [39, 114, 139] and early studies of the adult outcomes of children treated with stimulant medications have suggested that final adult height is not affected [55, 71].”

    From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [71]

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Authors
Klein, R. G.
Affiliations
Long Island Jewish Medical Center (US)
Corresponding author
Klein, Rachel Gittelman
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1988-12-01
Volume
45
Issue
12
Pages
1127
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1988.01800360075011
OpenAlex
W2011464438
Cited by
156
References
29
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 2 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 1 · 2012: 6
FWCI
4.11
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH-18579)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroethics, Human Enhancement, Biomedical Innovations
Keywords
methylphenidate, hyperactive children, growth rate, drug withdrawal, height, weight, ADHD medication
MeSH terms
Adolescent, Attention Deficit Disorder with Hyperactivity, Body Height, Body Weight, Child, Child Development, Clinical Trials as Topic, Female, Growth, Growth Disorders, Humans, Male, Methylphenidate

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