Glycemic response to glucagon during fasting hypoglycemia: an aid in the diagnosis of hyperinsulinism
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An exaggerated glycemic response to glucagon (>30 mg/dL) is nearly pathognomonic of hyperinsulinism.
“An exaggerated glycemic response (>30 mg/dL [>1.7 mmol/L]) is nearly pathognomonic of hyperinsulinism.33”
From Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children (2015) · cites this paper as [33]
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“7 mmol/L]) is nearly pathognomonic of hyperinsulinism.(33) Because plasma insulin concentration is sometimes not above the lower limit of detection,(34) it is important to include the following tests when assessing the possibility of hypoglycemia due to hyperinsulinism: plasma BOHB and FFA (both inappropriately low; B…”
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- Authors
- Finegold, D. N., Stanley, C. A., & Baker, L.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Finegold, David N.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 1980-02
- Volume
- 96
- Issue
- 2
- Pages
- 257-259
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2003513415
- Cited by
- 150
- References
- 12
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 1 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 9 · 2014: 5 · 2013: 6 · 2012: 3
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- hyperinsulinism, fasting hypoglycemia, glucagon stimulation test, glycemic response, insulin secretion, beta-hydroxybutyrate, infants, hypoglycemia diagnosis
- MeSH terms
- Blood Glucose, Child, Child, Preschool, Female, Glucagon, Humans, Hyperinsulinism, Hypoglycemia, Infant, Infant, Newborn, Male
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