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Cited by 67Influenza Virus Research StudiesMuscle and Compartmental DisordersInfectious Encephalopathies and Encephalitis

Epidemic influenza myopathy in Cincinnati in 1977

Farrell, Michael K., Partin, John C., Bove, Kevin E., Jacobs, Robert, Hilton, Pamela K.·1980·The Journal of Pediatrics
DOI 10.1016/s0022-3476(80)80864-x
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Abstract

A distinctive myopathy was observed in 24 children following influenza B infection. The abrupt onset of severe muscle pain and difficulty in walking began as the respiratory symptoms were waning. The lower extremities, particularly the gastrocnemius and soleus muscles, were involved preferentially. Nasopharyngeal cultures were positive for influenza B Hong Kong in 18 of these patients. Serum creatine phosphokinase levels were significantly elevated (mean 55.2 units) when compared to controls and nine patients with Reye syndrome. The cardiac muscle isoenzyme was detected in the serum of 17 myopathy patients. Serum glutamic oxaloacetic transaminase, but not serum glutamic pyruvic transaminase, was elevated compared to controls (P less than 0.01) but less (P less than 0.001) than the patients with Reye syndrome. Twelve patients underwent muscle biopsy; segmental rhabdomyolysis without inflammation was detected in nine patients. Myopathy is a complication of influenza infection that can be diagnosed by clinical, biochemical, and virologic examination.

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Authors
Farrell, M. K., Partin, J. C., Bove, K. E., Jacobs, R., & Hilton, P. K.
Affiliations
Cincinnati Children's Hospital Medical Center (US)
Corresponding author
Farrell, Michael K.
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
1980-03
Volume
96
Issue
3
Pages
545-551
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/s0022-3476(80)80864-x
OpenAlex
W2004930312
Cited by
67
References
40
Citations by year
2022: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2016: 3 · 2014: 4 · 2013: 3 · 2012: 3
FWCI
2.63
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
Keywords
influenza B, rhabdomyolysis, myalgia, creatine kinase, aspartate aminotransferase, Reye's syndrome, children, Cincinnati
MeSH terms
Child, Disease Outbreaks, Female, Humans, Influenza, Human, Male, Muscular Diseases, Ohio

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