Morphology of acute myopathy associated with influenza B infection
Abstract
Calf muscle samples were obtained from 12 children with transient incapacitating myalgia and proved infection of the upper respiratory tract with influenza virus, type B. In all except one, light microscopy revealed isolated segmental muscle fiber degeneration and necrosis without frank myositis. Ultrastructural studies revealed that in zones of segmental necrosis, the sarcolemma was lysed but the basement membrane was intact. Focal degenerative changes included myofibrillar disarray with disruption/loss of the sarcoplasmic reticulum, glycogen depletion accompanied by mitochondriopathy, subsarcolemmal mitochondrial aggregates, activation of satellite cells, and focal filopodial transformation of the sarcolemma. The primary event in the pathogenesis of focal muscle fiber necrosis is likely to be biochemical and was not elucidated, but the focal sarcolemmal and T-tubule changes and mitochondriopathy suggest that destabilization of cell membranes may play a critical role. Sarcolemmal filopodia may be a marker for a specific type of membrane injury, but we were unable to establish that influenza virus has a direct role in its genesis.
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Histological descriptions of influenza B-associated skeletal myopathy are remarkably similar to the cardiac pathology identified in several of the case patients in our series.
“Histological descriptions of influenza B-associated skeletal myopathy are remarkably similar to the cardiac pathology identified in several of the case patients in our series”
From Myocardial Injury and Bacterial Pneumonia Contribute to the Pathogenesis of Fatal Influenza B Virus Infection (2012) · cites this paper as [43]
Histological descriptions of influenza B-associated skeletal myopathy include randomly distributed foci of segmental hyaline degeneration and necrosis of individual fibers, often in the absence of any inflammatory infiltrates.
“include randomly distributed foci of segmental hyaline degeneration and necrosis of individual fibers, often in the absence of any inflammatory infiltrates [43,44]”
From Myocardial Injury and Bacterial Pneumonia Contribute to the Pathogenesis of Fatal Influenza B Virus Infection (2012) · cites this paper as [43]
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Paddock, C. D., Liu, L., Denison, A. M., Bartlett, J. H., Holman, R. C., DeLeon-Carnes, M., Emery, S. L., Drew, C. P., Shieh, W.-J., Uyeki, T. M., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir861 · Cited by 171 · see citing works
- Authors
- Bove, K. E., Hilton, P. K., Partin, J., & Farrell, M. K.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Venue
- Pediatric Pathology
- Publisher
- Informa UK Limited
- Published
- 1983-01
- Volume
- 1
- Issue
- 1
- Pages
- 51-66
- ISSN
- 0277-0938 (ISSN-L)
- OpenAlex
- W2122664590
- Cited by
- 26
- References
- 16
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 2 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Keywords
- influenza B, acute myopathy, muscle fiber degeneration, glycogen depletion, sarcoplasmic reticulum, myofibrillar disarray, satellite cells, T-tubules, triceps surae
- MeSH terms
- Child, Humans, Influenza, Human, Microscopy, Electron, Mitochondria, Muscle, Muscles, Muscular Diseases, Myofibrils, Influenza B virus, Sarcolemma, Virion
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