The DOI matches its Crossref record; 25 of the 26 references it cites were found in a registry or an index.
Impaired natural killer activity in lymphohistiocytosis syndrome
Abstract
In six patients with well-documented lymphohistiocytosis syndrome, natural killer activity was found to be profoundly impaired and could not be increased by incubation in vitro with interferon. This abnormality was not found in parents of the affected children. A clear correlation with the activity of the disease was observed, although a delay of a few weeks (possibly reflecting the life span of NK cells in blood) was seen in the disappearance of NK activity after the onset of the disease and its reappearance after remission. No absolute correlation was observed between NK activity and percentage of leukocytes detected by the Leu-7 monoclonal antibody. Our findings indicate that testing NK activity is useful for the diagnosis of lymphohistiocytosis syndrome and can be used as an index of activity of the disease, among other major clinical and biologic signs of this syndrome. Reversal of the NK activity defect (rather than detection of Leu-7 positive cells) appears to be a good criterion of complete remission.
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“The cytolytic function of NK cells is diminished in some forms of cytokine storm, which can lead to prolonged antigenic stimulation and difficulty resolving inflammation.”
From Cytokine storm (2020) · cites this paper as [17]
Citations
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Cited by
Sorted by citations
Items 101–121 of 121
Hemophagocytic syndrome and Kaposi sarcoma after liver transplantation
Voskanyan, S. E., Евгеньевич, С. В., Maltseva, A. P., Рудаков, В. С., Svetlakova, D. S., Davtyan, A., Simavonyan, Z. K., Gallyamova, А. R., Probatova, N. A., Gorodetskiy, V. R., et al. (2018) · Transplantologiya The Russian Journal of Transplantation · doi:10.23873/2074-0506-2018-10-2-126-141 · Cited by 3
Les lymphohistiocytoses hémophagocytaires
Stalder, G., Ribi, C., & Duchosal, M. A. (2018) · Praxis · doi:10.1024/1661-8157/a003045 · Cited by 2
History of Hemophagocytic Lymphohistiocytosis
Janka, G. (2019) · Springer eBooks · doi:10.1007/978-3-030-22094-5_1 · Cited by 2
CD8+ T Cell Biology in Cytokine Storm Syndromes
Sekine, T., Galgano, D., Casoni, G. P., Meeths, M., & Bryceson, Y. T. (2019) · Springer eBooks · doi:10.1007/978-3-030-22094-5_9 · Cited by 2
Limfohistiocytoza hemofagocytarna u dzieci
Wołowiec, M., & Malinowska, I. (2016) · Acta Haematologica Polonica · doi:10.1016/j.achaem.2016.10.001 · Cited by 2
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Cahill, H., Wynn, R. F., & Senthil, S. (2026) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2026.2691043 · Cited by 1
“Impairment of granule-mediated cytotoxic natural killer (NK) cells and cytotoxic T cells, along with proliferation and infiltration of inflammatory cells into key organs, contributes to the clinical features seen in HLH [1].”
Rodzinna limfohistiocytoza – seria niefortunnych zdarzeń
Klaudel‐Dreszler, M., Piątosa, B., & Bernatowska, E. A. (2007) · Pediatria Polska · doi:10.1016/s0031-3939(07)70337-2 · Cited by 1
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TRIGGERING AND MECHANISMS OF NATURAL KILLER CELL MEDIATED CYTOTOXICITY
Bryceson, Y. T. (2008) · Figshare
Haemophagocytic lymphohistiocytosis in Adult- A Case Report and Literature Review
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化学療法と同種骨髄移植により3年以上初回寛解を維持しているfamilial erythrophagocytic lymphohistiocytosis (FEL) の1例
桜井, 裕., 佳子, 片., 隆夫, 吉., 聡, 生., 伸二郎, 東., 耕一, 坂., 岩見, 均., 康郎, 粕., 日比, 成., 義仁, 森., et al. (1991) · 日本小児血液学会雑誌 · doi:10.11412/jjph1987.5.439
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晋作, 今. (1991) · 日本小児血液学会雑誌 · doi:10.11412/jjph1987.5.349
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Sieni, E., Cetica, V., Santoro, A., Beutel, K., Mastrodicasa, E., Meeths, M., Ciambotti, B., Brugnolo, F., Pende, D., Moretta, L., et al. (2017)
Hämophagozytische Lymphohistiozytosen
Janka-Schaub, G. E., & Schneider, M. (2005) · Springer eBooks · doi:10.1007/3-540-29036-2_21
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Leishmania e linfoistiocitosi emofagocitica (HLH)
Bratta, A., Arcuri, L., & Micalizzi, C. (2025) · Medico e Bambino - Pagine Elettroniche · doi:10.53126/mebxxviiif51
The Discovery of the Familial Hemophagocytosis Syndromes
Basile, G. D. S., & Fischer, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407179-7.00012-6
Self-citation
Metadata
- Authors
- Perez, N., Virelizier, J.-L., Arenzana-Seisdedos, F., Fischer, A., & Griscelli, C.
- ORCID
- Fischer, Alain
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 1984-04
- Volume
- 104
- Issue
- 4
- Pages
- 569-573
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2059566117
- Cited by
- 121
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- natural killer cells, NK cell dysfunction, interferon, disease activity monitoring, remission, NK cell depletion
- MeSH terms
- Antibodies, Monoclonal, Cytotoxicity, Immunologic, Fluorescent Antibody Technique, Humans, Killer Cells, Natural, Leukocytes, Lymphatic Diseases
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