CoChat
Sign Up
Cited by 186Growth Hormone and Insulin-like Growth FactorsPituitary Gland Disorders and TreatmentsAcute Lymphoblastic Leukemia research

Reduced pulsatile growth hormone secretion in children after therapy for acute lymphoblastic leukemia

Blatt, Julie, Bercu, Barry B., Christopher Gillin, J., Mendelson, Wallace B., Poplack, David G.·1984·The Journal of Pediatrics
DOI 10.1016/s0022-3476(84)80989-0
Open this paper in CoChat — free account

Abstract

Basal growth hormone levels were measured every 20 minutes over 24 hours in eight long-term survivors of acute lymphoblastic leukemia and in 13 age- and pubertal stage-matched normal children. Among the patients, the median total basal growth hormone output (AUC) was 43 units, compared with 341 units in the normal control group (P less than 0.001). In the patients, mean pulse amplitude (6.9 ng/ml) and frequency (4.6) over 24 hours also were reduced, compared with the control values (32 ng/ml and 8.5, P less than 0.001 and P less than 0.05, respectively). In addition, normal children secreted more GH at night (median AUC 280) than during the day (113, P less than 0.001). However, this diurnal pattern was absent in three of the patients studied. These data suggest that perturbations of spontaneous pulsatile GH secretion are common after standard therapy for ALL and may be a sensitive means of detecting therapy-related neuroendocrine damage. Blunting of spontaneous pulsatile GH secretion may contribute to the abnormalities in growth seen in children with ALL.

Integrity signals

Registry

Crossref · 10.1016/s0022-3476(84)80989-0

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Overnight (12 h) spontaneous GH secretion has been found to be lower than normal in some children after cranial irradiation and can indicate a subtle GH defect.

    “Overnight (12 h) spontaneous GH secretion has been found to be lower than normal in some children after cranial irradiation (another example of hypothalamic injury), and can indicate a subtle GH defect [54].”

    From Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury (2015) · cites this paper as [54]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Blatt, J., Bercu, B. B., Christopher Gillin, J., Mendelson, W. B., & Poplack, D. G.
Corresponding author
Poplack, David G.
ORCID
Blatt, Julie
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
1984-02
Volume
104
Issue
2
Pages
182-186
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/s0022-3476(84)80989-0
OpenAlex
W2086814988
Cited by
186
References
19
Citations by year
2022: 2 · 2021: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 1
FWCI
10.83
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
Keywords
growth hormone secretion, pulsatile secretion, acute lymphoblastic leukemia, childhood cancer survivors, neuroendocrine toxicity, diurnal variation, abnormal growth, chemotherapy side effects
MeSH terms
Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, Brain, Child, Circadian Rhythm, Female, Humans, Injections, Spinal, Leukemia, Lymphoid, Male, Methotrexate, Growth Hormone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review