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Cited by 16Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesPituitary Gland Disorders and Treatments

Six-hour and four-hour nocturnal sampling for growth hormone

Rose, S.R., Municchi, G.·1999·Journal of Pediatric Endocrinology and Metabolism
DOI 10.1515/jpem.1999.12.2.167
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Abstract

UNLABELLED: Overnight sampling for growth hormone (GH) is a research tool for quantifying characteristics of spontaneous GH secretion. However, the study is costly in assays and blood volume, particularly that required from a small child. DESIGN AND PATIENTS: Existing overnight GH data from 126 normal children and from 227 children with GH deficiency or short stature were reanalyzed, examining 6-h and 4-h segments of this data for accuracy in representing each child's 12-h GH secretion. The goal was to see whether the test could be made shorter and more practical without losing accuracy. RESULTS: The 6-h segment 2200-0400 h consistently contained the majority of GH peaks. Correlation was high between GH values from 2200-0400 h and from the 12-h period. Normal 95% confidence limits (CL) for GH during 2200-0400 h were derived from data in normal children for gender and each pubertal stage. Data from short children were compared with the normal 6-h 95% CL. In short children, GH values low for 12-h were also low for 6-h. Only a few children with normal 12-h values (1.5% of normals, 0.5% with short stature) had GH values outside 95% CL for 6-h. CONCLUSIONS: Six-hour GH sampling (2200-0400 h) is accurate and cost-efficient compared to the 12-h overnight GH study. These studies are primarily useful in research settings.

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Crossref · 10.1515/jpem.1999.12.2.167

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  • A 6 h sampling of GH levels from 2200 to 0400 h can accurately demonstrate a child's ability to release GH and is less invasive than a 12 h sampling period, although measurement of overnight secretory pattern of GH for clinical diagnosis remains controversial.

    “A 6 h sampling of GH levels, from 2200 to 0400 h (normative results [55]), can accurately demonstrate a child’s ability to release GH, and is less invasive than a 12 h sampling period, although measurement of overnight secretory pattern of GH for clinical diagnosis remains controversial.”

    From Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury (2015) · cites this paper as [55]

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Authors
Rose, S. R., & Municchi, G.
Affiliations
University of Tennessee Health Science Center (US)
ORCID
Rose, S.R.
Venue
Journal of Pediatric Endocrinology and Metabolism
Publisher
Walter de Gruyter GmbH
Published
1999-01
Volume
12
Issue
2
Pages
167-73
ISSN
  • 0334-018X (ISSN-L)
  • 2191-0251
DOI
10.1515/jpem.1999.12.2.167
OpenAlex
W2320514928
Cited by
16
References
13
Citations by year
2024: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2015: 2 · 2013: 2
FWCI
0.69
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pediatric Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Research Resources (5MO1RR00997, M01RR000997)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
growth hormone secretion, GH deficiency, short stature, pubertal stage, children
MeSH terms
Adolescent, Child, Circadian Rhythm, Evaluation Studies as Topic, Female, Growth Disorders, Humans, Male, Reference Values, Retrospective Studies, Growth Hormone, Time Factors

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