Growth hormone secretory dynamics in Turner syndrome
Abstract
We investigated whether a decrease in serum growth hormone contributes to the short stature of adults with Turner syndrome by measuring the 24-hour profile of serum growth hormone in 30 patients aged 2 to 20 years. Growth hormone pulses were defined as a rise from nadir to peak that exceeded three times the intraassay coefficient of variation. Girls with Turner syndrome aged 2 to 8 years did not have statistically different growth hormone levels, peak amplitudes, and peak frequencies compared with those in age-matched controls. By contrast, girls with Turner syndrome aged 9 to 20 years had significantly decreased mean 24-hour growth hormone levels, peak amplitudes, and peak frequencies compared with those in age-matched normal girls. Patients with Turner syndrome of all ages had decreased serum somatomedin-C concentrations and delayed bone ages. We conclude that a relative deficiency of growth hormone in pubertal patients with Turner syndrome may contribute to their adult short stature.
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Perturbations in GH and IGF-I physiology, including IGF-I resistance and estrogen deficiency, may also contribute to impaired linear growth.
“However, perturbations in GH and insulin-like growth factor-I (IGF-I) physiology,146,147 including resistance to IGF-I,148-150 and estrogen deficiency151 may also contribute to impaired linear growth.”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [147]
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- Authors
- Ross, J. L., Long, L. M., Loriaux, D. L., & Cutler, G. B.
- Affiliations
- National Institutes of Health (US)
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 1985-02
- Volume
- 106
- Issue
- 2
- Pages
- 202-206
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W1978820941
- Cited by
- 156
- References
- 16
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 2 · 2020: 1 · 2019: 3 · 2016: 1 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- Turner syndrome, growth hormone secretion, short stature, insulin-like growth factor I, bone age, puberty, adult height
- MeSH terms
- Adolescent, Adult, Age Determination by Skeleton, Child, Child, Preschool, Circadian Rhythm, Female, Humans, Insulin-Like Growth Factor I, Somatomedins, Growth Hormone, Time Factors, Turner Syndrome
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