Cited by 156Growth Hormone and Insulin-like Growth FactorsGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesHypothalamic control of reproductive hormones

Growth hormone secretory dynamics in Turner syndrome

Ross, Judith Levine, Long, Lauren Meyerson, Loriaux, D. Lynn, Cutler, Gordon B.·1985·The Journal of Pediatrics

Abstract

We investigated whether a decrease in serum growth hormone contributes to the short stature of adults with Turner syndrome by measuring the 24-hour profile of serum growth hormone in 30 patients aged 2 to 20 years. Growth hormone pulses were defined as a rise from nadir to peak that exceeded three times the intraassay coefficient of variation. Girls with Turner syndrome aged 2 to 8 years did not have statistically different growth hormone levels, peak amplitudes, and peak frequencies compared with those in age-matched controls. By contrast, girls with Turner syndrome aged 9 to 20 years had significantly decreased mean 24-hour growth hormone levels, peak amplitudes, and peak frequencies compared with those in age-matched normal girls. Patients with Turner syndrome of all ages had decreased serum somatomedin-C concentrations and delayed bone ages. We conclude that a relative deficiency of growth hormone in pubertal patients with Turner syndrome may contribute to their adult short stature.

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Crossref · 10.1016/s0022-3476(85)80287-0

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16 of 16 references verified0 citation errors · 0 not checkable

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  • Perturbations in GH and IGF-I physiology, including IGF-I resistance and estrogen deficiency, may also contribute to impaired linear growth.

    “However, perturbations in GH and insulin-like growth factor-I (IGF-I) physiology,146,147 including resistance to IGF-I,148-150 and estrogen deficiency151 may also contribute to impaired linear growth.”

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Authors
Ross, J. L., Long, L. M., Loriaux, D. L., & Cutler, G. B.
Affiliations
National Institutes of Health (US)
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
1985-02
Volume
106
Issue
2
Pages
202-206
ISSN
0022-3476 (ISSN-L)
OpenAlex
W1978820941
Cited by
156
References
16
Citations by year
2026: 1 · 2024: 1 · 2022: 2 · 2020: 1 · 2019: 3 · 2016: 1 · 2014: 4 · 2013: 2 · 2012: 2
FWCI
8.93
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
Turner syndrome, growth hormone secretion, short stature, insulin-like growth factor I, bone age, puberty, adult height
MeSH terms
Adolescent, Adult, Age Determination by Skeleton, Child, Child, Preschool, Circadian Rhythm, Female, Humans, Insulin-Like Growth Factor I, Somatomedins, Growth Hormone, Time Factors, Turner Syndrome

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