Age-related change in the twenty-four-hour spontaneous secretion of growth hormone

FINKELSTEIN, JORDAN W.; ROFFWARG, HOWARD P.; BOYAR, ROBERT M.; KREAM, JACOB; HELLMAN, LEON

doi:10.1210/jcem-35-5-665

Cited by 640Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesPituitary Gland Disorders and Treatments

Age-related change in the twenty-four-hour spontaneous secretion of growth hormone

FINKELSTEIN, JORDAN W., ROFFWARG, HOWARD P., BOYAR, ROBERT M., KREAM, JACOB, HELLMAN, LEON·1972·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-35-5-665

Open this paper in CoChat — free account

Abstract

Spontaneous growth hormone secretion rates and secretory patterns were studied in a group of normal prepubertal children, adolescents and young and older adults by determining the concentration of growth hormone in plasma samples obtained at 20-min intervals over a 24-hr period. Prepubertal children secreted growth hormone only during sleep and not while awake and had a mean secretion rate of 91 μg/24 hr (range 54–122 μg/24 hr). Mean duration of secretion was 110 min/24 hr (range 60–180 min/24 hr). Adolescents secreted growth hormone during both awake and sleep periods and had a mean secretion rate of 690 μg/24 hr (range 391–1406 μg/24 hr). Mean duration of secretion was 226 min/24 hr (range 100–300 min/24 hr). Secretion rates in young adults (21–41 yr) averaged 385 μg/24 hr (range 215–769 μg/24 hr). Average duration of secretion was 133 min/24 hr (range 100–300 min/24 hr). Growth hormone was secreted during both awake and asleep periods but the number of secretory episodes was less than in adolescents. In older adults (42–62 yr) the total 24-hr secretion of growth hormone decreased and approached zero in three of five studies. These data clearly demonstrate an age related change in the spontaneous secretory rate and secretory pattern of growth hormone.

Integrity signals

Registry

Crossref · 10.1210/jcem-35-5-665

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The magnitude of GH pulses peaks during puberty and then declines at about 1-2% per year until death in men and women.
“The magnitude of GH pulses peak during puberty and subsequently decline at a gradual rate of approximately 1-2% per year until death in men and women.59-61”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [59]

Sorted by citations

Effects of Human Growth Hormone in Men over 60 Years Old
Rudman, D. R., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., Schlenker, R. A., Cohn, L., Rudman, I. W., & Mattson, D. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230101 · Cited by 1,551 · see citing works
Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations
HO, K. Y., EVANS, W. S., BLIZZARD, R. M., VELDHUIS, J. D., MERRIAM, G. R., SAMOJLIK, E., FURLANETTO, R., ROGOL, A. D., KAISER, D. L., & THORNER, M. O. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-51 · Cited by 921 · see citing works
Human growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911 · see citing works
Sexual Dimorphism in the Control of Growth Hormone Secretion*
Jansson, J., Edén, S., & Isaksson, O. G. P. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-2-128 · Cited by 745 · see citing works
Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men
IRANMANESH, A., LIZARRALDE, G., & VELDHUIS, J. D. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1081 · Cited by 672 · see citing works
Impaired growth hormone secretion in the adult population: relation to age and adiposity.
Rudman, D. R., Kutner, M., Rogers, C. M., Lubin, M., Fleming, G. A., & Bain, R. P. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110164 · Cited by 641 · see citing works
Neuroendocrine Control of Growth Hormone Secretion
Müller, E. E., Locatelli, V., & Cocchi, D. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.511 · Cited by 631 · see citing works
The Influence of Age on the 24-Hour Integrated Concentration of Growth Hormone in Normal Individuals*
Zadik, Z., CHALEW, A., McCarter, R., Meistas, M. T., & Kowarski, A. A. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-3-513 · Cited by 596 · see citing works
Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.
Ho, K. Y., Veldhuis, J. D., Johnson, M. L., Furlanetto, R., Evans, W. S., Alberti, K. G., & Thorner, M. O. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113450 · Cited by 503 · see citing works
“Mdenotes meal times; GRFdenotes intravenous injection of I jg/kg GHRH(1-40)-OH.”
BackgroundMethod
Effects of heavy-resistance training on hormonal response patterns in younger vs. older men
Kraemer, W. J., Häkkinen, K., Newton, R. U., Nindl, B. C., Volek, J. S., McCormick, M., Gotshalk, L. A., Gordon, S. E., Fleck, S. J., Campbell, W. W., et al. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.3.982 · Cited by 467 · see citing works
“Because of the pulsatile nature of GH, single resting measures must be interpreted cautiously, especially in younger men, who show a much more prominent pulsatile secretion (11, 71).”
Background
Mode of Action of Pituitary Growth Hormone on Target Cells
Isaksson, O. G. P., Edén, S., & Jansson, J. (1985) · Annual Review of Physiology · doi:10.1146/annurev.ph.47.030185.002411 · Cited by 450 · see citing works
The Diagnosis of Growth Hormone Deficiency in Children and Adults
Shalet, S. M., Toogood, A., Rahim, A., & Brennan, B. M. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.2.0329 · Cited by 414 · see citing works
Effect of adenotonsillectomy on nocturnal hypoxaemia, sleep disturbance, and symptoms in snoring children
STRADLING, J. (1990) · The Lancet · doi:10.1016/0140-6736(90)90068-g · Cited by 399 · see citing works
Chronobiology of aging: Temperature, sleep-wake rhythms and entrainment
Weitzman, E. D., Moline, M. L., Czeisler, C. A., & Zimmerman, J. C. (1982) · Neurobiology of Aging · doi:10.1016/0197-4580(82)90018-5 · Cited by 367 · see citing works
Neuroendocrine rhythms and sleep in aging men
van Coevorden, A., Mockel, J., Laurent, E., Kerkhofs, M., L'Hermite-Baleriaux, M., Decoster, C., Neve, P., & Van Cauter, E. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.260.4.e651 · Cited by 336 · see citing works
The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition
Binnerts, A., Swart, G. R., Wilson, J. H. P., Hoogerbrugge, N., Pois, H. A. P., Birkenhager, J. C., & Lamberts, S. W. J. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02287.x · Cited by 315 · see citing works
“secretion continues into normal adult life, however, although it decreases over time in later age (Finkelstein et al., 1972; Rudman et al., 1982; Zadik et al., 1985).”
Background
Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenon.
MAURAS, N., BLIZZARD, R. M., LINK, K., JOHNSON, M. L., ROGOL, A. D., & VELDHUIS, J. D. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-3-596 · Cited by 300 · see citing works
Spontaneous Growth Hormone Secretion Increases during Puberty in Normal Girls and Boys*
Rose, S. R., Municchi, G., Barnes, K. M., Kamp, G. A., Uriarte, M., ROSS, J. L., CASSORLA, F. G., & Cutler, G. B. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-2-428 · Cited by 293 · see citing works
GH3 pituitary adenoma cells can reverse thymic aging in rats.
Kelley, K. W., Brief, S., Westly, H. J., NOVAKOFSKI, J. E., Bechtel, P. J., Simon, J. R., & Walker, E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.15.5663 · Cited by 279 · see citing works
Quantification of hormone pulsatility via an approximate entropy algorithm
Pincus, S. M., & Keefe, D. L. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.5.e741 · Cited by 262 · see citing works
The Role of Somatostatin in the Regulation of Anterior Pituitary Hormone Secretion and the Use of Its Analogs in the Treatment of Human Pituitary Tumors
Lamberts, S. W. J. (1988) · Endocrine Reviews · doi:10.1210/edrv-9-4-417 · Cited by 266 · see citing works
Neural Regulation of Growth Hormone Secretion
Martin, J. B. (1973) · New England Journal of Medicine · doi:10.1056/nejm197306282882606 · Cited by 268 · see citing works
Endogenous growth hormone secretion and clearance rates in normal boys, as determined by deconvolution analysis: relationship to age, pubertal status, and body mass.
Martha, P. M., Gorman, K. M., Blizzard, R. M., Rogol, A. D., & Veldhuis, J. D. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.2.1730812 · Cited by 268 · see citing works
Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging
Sonntag, W. E., Ramsey, M. M., & Carter, C. S. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.02.001 · Cited by 254 · see citing works
Analyses of 24-Hour Growth Hormone Profiles in Children: Relation to Growth*
Albertsson-Wikland, K. G., & Rosberg, S. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-3-493 · Cited by 252 · see citing works
Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans
Fryburg, D. A., Gelfand, R. A., & Barrett, E. J. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.260.3.e499 · Cited by 254 · see citing works
Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects.
Rasmussen, M. H., HVIDBERG, A. D., Juul, A., Main, K. M., Gotfredsen, A., Skakkebæk, N. E., Hilsted, J., & Skakkebae, N. E. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.4.7536210 · Cited by 248 · see citing works
The Advantage of Measuring Stimulated as Compared with Spontaneous Growth Hormone Levels in the Diagnosis of Growth Hormone Deficiency
Rose, S. R., ROSS, J. L., Uriarte, M., Barnes, K. M., CASSORLA, F. G., & Cutler, G. B. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807283190403 · Cited by 243 · see citing works
VIP neurons in the human SCN in relation to sex, age, and Alzheimer's disease
Zhou, J. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00043-e · Cited by 243 · see citing works
AGE-RELATED CHANGES IN PLASMA GROWTH HORMONE RESPONSE TO GROWTH HORMONE-RELEASING FACTOR IN MAN
Shibasaki, T., SHIZUME, K., Nakahara, M., Masuda, A., Jibiki, K., Demura, H., Wakabayashi, I., & LING, N. C. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-58-1-212 · Cited by 231 · see citing works
Pleiotropic Effects of Growth Hormone and Insulin-like Growth Factor (IGF)-1 on Biological Aging: Inferences From Moderate Caloric-Restricted Animals
Sonntag, W. E., Lynch, C. D., Cefalu, W. T., Ingram, R. L., Bennett, S. A., Thornton, P. L., & Khan, A. S. (1999) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/54.12.b521 · Cited by 229 · see citing works
Growth and development following marrow transplantation for leukemia
Sanders, J., Pritchard, S., Mahoney, P., Amos, D. B., Buckner, C. D., Witherspoon, R., Deeg, H. J., Doney, K., Sullivan, K. M., & Appelbaum, F. R. (1986) · Blood · doi:10.1182/blood.v68.5.1129.1129 · Cited by 230 · see citing works
The Somatomedins: Insulin-Like Growth Factors
Baxter, R. C. (1986) · Advances in clinical chemistry · doi:10.1016/s0065-2423(08)60124-9 · Cited by 227 · see citing works
Growth Hormone in the Brain: Characteristics of Specific Brain Targets for the Hormone and Their Functional Significance
Nyberg, F. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2000.0200 · Cited by 228 · see citing works
Alterations in the Pulsatile Properties of Circulating Growth Hormone Concentrations during Puberty in Boys*
MARTHA, P. M., Rogol, A. D., Veldhuis, P. P., Kerrigan, J. R., GOODMAN, D. W., & Blizzard, R. M. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-3-563 · Cited by 225 · see citing works
Growth hormone, insulin-like growth factor-1 and the aging brain
Ashpole, N. M., Sanders, J. E., Hodges, E. L., Han, Y., & Sonntag, W. E. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.10.002 · Cited by 226 · see citing works
Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness
Checkley, S. A. (1980) · Psychological Medicine · doi:10.1017/s0033291700039593 · Cited by 224 · see citing works
“Effects of age are less significant (Finkelstein et al. 1972; Plotnik et al. 1975; Thorner, 1977) and are not difficult to control.”
Background
“White Paper” on Sleep and Aging
Dement, W. C., Miles, L. E. M., & Carskadon, M. A. (1982) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1982.tb03700.x · Cited by 222 · see citing works
Growth hormone, lymphocytes and macrophages
Kelley, K. W. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90222-0 · Cited by 222 · see citing works
Physiologic Aspects of Aging
Sawhney, R., Sehl, M. E., & Naeim, A. (2005) · The Cancer Journal · doi:10.1097/00130404-200511000-00004 · Cited by 216 · see citing works
Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications
Pataky, M. W., Young, W. F., & Nair, K. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.07.033 · Cited by 207 · see citing works
The Impact of Gonadal Steroid Hormone Action on Growth Hormone Secretion During Childhood and Adolescence*
Kerrigan, J. R., & Rogol, A. D. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-2-281 · Cited by 209 · see citing works
How to Measure Adipose Tissue Insulin Sensitivity
Søndergaard, E., Ycaza, A. E. E. D., Morgan-Bathke, M. E., & Jensen, M. D. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00047 · Cited by 202 · see citing works
Basal Plasma Growth Hormone Levels in Man: New Evidence for Rhythmicity of Growth Hormone Secretion*
Winer, L. M., SHAW, M. A., & Baumann, G. P. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-6-1678 · Cited by 194 · see citing works
Endocrinology of puberty
Root, A. W. (1973) · The Journal of Pediatrics · doi:10.1016/s0022-3476(73)80305-1 · Cited by 187 · see citing works
The Effect of Androgens on the Pulsatile Release and the Twenty-Four-Hour Mean Concentration of Growth Hormone in Peripubertal Males*
Link, K., Blizzard, R. M., Evans, W. S., Kaiser, D. L., Parker, M. W., & Rogol, A. D. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-1-159 · Cited by 182 · see citing works
Serum Bone Gla-Protein as a Marker of Bone Growth in Children and Adolescents: Correlation With Age, Height, Serum Insulin-Like Growth Factor I, and Serum Testosterone*
Johansen, J. S., Giwercman, A., Hartwell, D., Nielsen, C. T., Price, P. A., Christiansen, C., & Skakkebæk, N. E. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-2-273 · Cited by 184 · see citing works
Circadian Rhythms and Episodic Hormone Secretion in Man
Weitzman, E. D. (1976) · Annual Review of Medicine · doi:10.1146/annurev.me.27.020176.001301 · Cited by 184 · see citing works
Activation of the somatotropic axis by testosterone in adult males: evidence for the role of aromatization
Weissberger, A. J., & Ho, K. K. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.6.8501143 · Cited by 185 · see citing works
A chronometric approach to the study of feeding behavior
Armstrong, S. (1980) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(80)90024-x · Cited by 184 · see citing works
Menopause in Nonhuman Primates?1
Walker, M. L., & Herndon, J. G. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.108.068536 · Cited by 184 · see citing works
Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system
Khan, A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00533-8 · Cited by 172 · see citing works
Nyctohemeral Growth Hormone Profiles in Young and Aged Men: Correlation with Somatomedin-C Levels*
Vermeulen, A. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-5-884 · Cited by 170 · see citing works
Mechanisms Limiting Body Growth in Mammals
Lui, J. C. K., & Baron, J. (2011) · Endocrine Reviews · doi:10.1210/er.2011-0001 · Cited by 167 · see citing works
ALTERATIONS WITH AGING OF THE ENDOCRINE AND NEUROENDOCRINE CIRCADIAN SYSTEM IN HUMANS
Touitou, Y., & Haus, E. L. (2000) · Chronobiology International · doi:10.1081/cbi-100101052 · Cited by 169 · see citing works
“…with a dramatic decrease in both frequency and amplitude of the pulses, leading to a decline of about 70% of plasma growth hormone levels when compared to young adults without apparent correlation with sleep structure changes (Finkelstein et al. 1972; Blichert-Toft 1975; Murri et al. 1980).”
Background
Daytime Pulsatile Growth Hormone Secretion during Childhood and Adolescence*
Miller, J. D., Tannenbaum, G. S., Colle, E., & Guyda, H. J. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-5-989 · Cited by 165 · see citing works
A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan
Carter, C. S., Ramsey, M. M., & Sonntag, W. E. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02696-3 · Cited by 163 · see citing works
Growth Hormone (GH) Responsiveness to Combined Administration of Arginine and GH-Releasing Hormone Does not Vary with Age in Man*
Ghigo, E., GOFFI, S., Nicolosi, M., Arvat, E., Valente, F., Mazza, E., GHIGO, M. C., & Camanni, F. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-6-1481 · Cited by 161 · see citing works
Linear growth as a function of age at onset of puberty and sex steroid dosage: therapeutic implications
BOURGUIGNON, J.-P. (1988) · Endocrine Reviews · doi:10.1210/edrv-9-4-467 · Cited by 158 · see citing works
“In several studies, integrated concentrations of GH were found to be higher in pubertal subjects of both sexes than those seen before puberty and during adulthood (25, 38, 72-75).”
Background
Body composition in growth hormone deficient adults
Binnerts, A., Deurenberg, P., Swart, G., Wilson, J., & Lamberts, S. W. J. (1992) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.5.918 · Cited by 159 · see citing works
The relationship between insulin-like growth factor-I, adiposity, and aging.
Copeland, K., Colletti, R., Devlin, J., & McAuliffe, T. (1990) · Metabolism: Clinical and Experimental · doi:10.1016/0026-0495(90)90022-5 · Cited by 175 · see citing works
Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men
Corpas, E., Harman, S. M., Piñeyro, M. A., Roberson, R. B., & Blackman, M. R. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.2.1379256 · Cited by 167 · see citing works
Growth hormone secretory dynamics in Turner syndrome
Ross, J. L., Long, L. M., Loriaux, D. L., & Cutler, G. B. (1985) · The Journal of Pediatrics · doi:10.1016/s0022-3476(85)80287-0 · Cited by 156 · see citing works
Atherosclerosis in diabetes: The role of hyperinsulinemia
STOLAR, M. W. (1988) · Metabolism · doi:10.1016/0026-0495(88)90180-1 · Cited by 153 · see citing works
Somatomedin-C in Normal Puberty and in True Precocious Puberty before and after Treatment with a Potent Luteinizing Hormone-Releasing Hormone Agonist*
Harris, D. A., Vliet, G. V., EGLI, C. A., Grumbach, M. M., Kaplan, S. L., Styne, D. M., & Vainsel, M. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-61-1-152 · Cited by 153 · see citing works
Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice
Kinney, B. A., Coschigano, K. T., Kopchick, J. J., Steger, R. W., & Bartke, A. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00423-1 · Cited by 148 · see citing works
Does childhood and adolescence provide a unique opportunity for exercise to strengthen the skeleton?
Karim, K., McKay, H. A., Haapasalo, H. H., Bennell, K. L., Forwood, M. R., Kannus, P., & Wark, J. D. (2000) · Journal of science and medicine in sport · doi:10.1016/s1440-2440(00)80077-8 · Cited by 146 · see citing works
Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging
Gong, Z., Tas, E., Yakar, S., & Muzumdar, R. H. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.022 · Cited by 147 · see citing works
Temporal structure of in vivo growth hormone secretory events in humans
Hartman, M. L., FARIA, A. C. S., Vance, M. L., Johnson, M. L., Thorner, M. O., & Veldhuis, J. D. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.260.1.e101 · Cited by 142 · see citing works
6 Growth hormone neurosecretory dysfunction
Bercu, B. B., & Diamond, F. (1986) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(86)80010-x · Cited by 144 · see citing works
Body composition response to exogenous GH during training in highly conditioned adults
Crist, D. M., Peake, G. T., Egan, P. A., et al. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.65.2.579 · Cited by 144 · see citing works
“5 mg/wk) in women (30), similar to amounts reported by others (6).”
Background
Chronobiology and Aging
Brock, M. (1991) · Journal of The American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb05909.x · Cited by 164 · see citing works
Age‐Related Alterations of the Growth Hormone/Insulin‐Like‐Growth‐Factor I Axis
KELIJMAN, M. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb01654.x · Cited by 139 · see citing works
Two Roads to Rapid Eye Movement Latency
Kupfer, D. J. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810100087016 · Cited by 140 · see citing works
Self-reported ballet classes undertaken at age 10–12 years and hip bone mineral density in later life
Khan, K. M., Bennell, K. L., Hopper, J. L., Flicker, L. A., Nowson, C. A., Sherwin, A. J., Crichton, K. J., Harcourt, P. R., & Wark, J. D. (1998) · Osteoporosis International · doi:10.1007/bf02672514 · Cited by 140 · see citing works
“GH increases 2- to 3-fold during this key period [ 56-59 ].”
Background
Changes in Growth and Serum Growth Hormone and Plasma Soipatomedin-C Levels During Suppression of Gonadal Sex Steroid Secretion in Girls with Central Precocious Puberty*
Mansfield, M. J., Rudlin, C., Crigler, J. F., Karol, K. A., Crawford, J. D., Boepple, P. A., & Crowley, W. F. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-1-3 · Cited by 137 · see citing works
Somatotropin Pulse Frequency and Basal Concentrations Are Increased in Acromegaly and Are Reduced by Successful Therapy*
Hartman, M. L., Veldhuis, J. D., Vance, M. L., FARIA, A. C. S., FURLANETTO, W., & Thorner, M. O. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-5-1375 · Cited by 135 · see citing works
Enuresis - Background and Treatment
Nevéus, T., Läckgren, G., Tuvemo, T., Hetta, J. E., Hjälmås, K., & Stenberg, A. (2000) · Scandinavian Journal of Urology and Nephrology · doi:10.1080/003655900750169257 · Cited by 151 · see citing works
Relationship between Cognitive Function, Growth Hormone and Insulin-Like Growth Factor I Plasma Levels in Aged Subjects
Rollero, A., Murialdo, G., Fonzi, S., Garrone, S., Gianelli, M. V., Gazzerro, E., Barreca, A., & POLLERI, A. (1998) · Neuropsychobiology · doi:10.1159/000026520 · Cited by 133 · see citing works
Chronic Sex Steroid Exposure Increases Mean Plasma Growth Hormone Concentration and Pulse Amplitude in Men with Isolated Hypogonadotropic Hypogonadism
Liu, L. L., Merriam, G. R., & Sherins, R. J. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-4-651 · Cited by 134 · see citing works
Effect of Testosterone on Somatomedin-C Concentrations in Prepubertal Boys*
Parker, M. W., Johanson, A. J., Rogol, A. D., Kaiser, D. L., & Blizzard, R. M. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-58-1-87 · Cited by 131 · see citing works
Increased Overnight Growth Hormone Concentrations in Diabetic Compared with Normal Adolescents
Edge, J. A., Dunger, D. B., Matthews, D. R., Gilbert, J. P., & Smith, C. P. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-5-1356 · Cited by 131 · see citing works
Responses of Growth Hormone (GH) and Somatomedin-C to GH-Releasing Hormone in Healthy Aging Men*
PAVLOVT, E. P., HARMAN, M. S., Merriam, G. R., Gelato, M. C., & Blackman, M. R. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-3-595 · Cited by 132 · see citing works
The Pubertal Growth Spurt in Eight Patients with True Precocious Puberty and Growth Hormone Deficiency: Evidence for a Direct Role of Sex Steroids*
Attie, K. M., Ramirez, N. R., Conte, F. A., Kaplan, S. L., & Grumbach, M. M. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-4-975 · Cited by 125 · see citing works
Evidence for a Direct in Vitro Action of Sex Steroids on Rabbit Cartilage Cells during Skeletal Growth: Influence of Age and Sex*
Corvol, M. T., Carrascosa, A., Tsagris, L., BLANCHARD, O., & Rappaport, R. (1987) · Endocrinology · doi:10.1210/endo-120-4-1422 · Cited by 126 · see citing works
Physiologic Aspects of Aging
Sehl, M. E., Sawhney, R., & Naeim, A. (2005) · The Cancer Journal · doi:10.1097/00130404-200511000-00005 · Cited by 122 · see citing works
Precocious puberty in girls: early diagnosis of a slowly progressing variant.
Fontoura, M., Brauner, R., Prévôt, C., et al. (1989) · Archives of Disease in Childhood · doi:10.1136/adc.64.8.1170 · Cited by 122 · see citing works
The Relationship of Sleep and Sleep Stages to Neuroendocrine Secretion and Biological Rhythms in Man
Weitzman, E. D., BOYAR, R. M., Kapen, S., & HELLMAN, L. (1975) · Elsevier eBooks · doi:10.1016/b978-0-12-571131-9.50015-3 · Cited by 120 · see citing works
Self-citation
40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain
Gubbi, S., Quipildor, G. F., Barzilai, N., Huffman, D. M., & Milman, S. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0093 · Cited by 115 · see citing works
GROWTH HORMONES AND SEX STEROID INTERACTIONS AT PUBERTY
Clark, P. A., & Rogol, A. D. (1996) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70346-7 · Cited by 113 · see citing works
Sleep, Biorhythms and Human Performance
Shephard, R. J. (1984) · Sports Medicine · doi:10.2165/00007256-198401010-00003 · Cited by 115 · see citing works
Characterization of 24‐hour growth hormone secretion in acromegaly: implications for diagnosis and therapy
Ho, K. K. Y., & Welssberger, A. J. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb03787.x · Cited by 111 · see citing works
Puberty in Nonhuman Primates and Humans
Plant, T. M., & Witchel, S. F. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50045-2 · Cited by 123 · see citing works
Regulation of Growth Hormone Secretion
Martin, J. B. (1986) · Springer eBooks · doi:10.1007/978-1-4615-7201-5_25 · Cited by 106 · see citing works
Neuroendocrinology of ageing
Rehman, H. U. (2001) · Age and Ageing · doi:10.1093/ageing/30.4.279 · Cited by 104 · see citing works
Administration of Low-Dose Estrogen Rapidly and Directly Stimulates Growth Hormone Production
Moll, G. (1986) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1986.02140160042027 · Cited by 105 · see citing works
Puberty in the Chimpanzee: Somatomedin-C and Its Relationship to Somatic Growth and Steroid Hormone Concentrations*
Copeland, K. C., Eichberg, J. W., Parker, C. R., & BARTKE, A. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-6-1154 · Cited by 103 · see citing works
Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning
Ramsey, M. M., Weiner, J. L., Moore, T. P., Carter, C. S., & Sonntag, W. E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.001 · Cited by 101 · see citing works
Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans
Veldhuis, J. D., Iranmanesh, A., & WELTMAN, A. L. (1997) · Endocrine · doi:10.1007/bf02778061 · Cited by 101 · see citing works
Chapter 16 Aging and circadian rhythms
van Gool, W. A., & Mirmiran, M. (1986) · Progress in brain research · doi:10.1016/s0079-6123(08)64309-5 · Cited by 102 · see citing works

Exogenous Glucocorticoids and a High-Fat Diet Cause Severe Hyperglycemia and Hyperinsulinemia and Limit Islet Glucose Responsiveness in Young Male Sprague-Dawley Rats
Beaudry, J. L., D'souza, A. M., Teich, T., Tsushima, R. G., & Riddell, M. C. (2013) · Endocrinology · doi:10.1210/en.2012-2114 · Cited by 44 · see citing works
The Effect of Fasting on Tissue Cyclic cAMP and Plasma Glucagon in the Obese Hyperglycemic Mouse
VINE, R. L. L., Voyles, N. R., Perrino, P. V., & Recant, L. (1975) · Endocrinology · doi:10.1210/endo-97-3-615 · Cited by 38 · see citing works
Modulation of Adipoinsular Axis in Prediabetic Zucker Diabetic Fatty Rats by Diazoxide
Alemzadeh, R., & Tushaus, K. (2004) · Endocrinology · doi:10.1210/en.2003-1523 · Cited by 38 · see citing works
Mechanisms of Impaired Growth Hormone Secretion in Genetically Obese Zucker Rats: Roles of Growth Hormone-Releasing Factor and Somatostatin*
TANNENBAUMt, G. S., Lapointe, M., Gurd, W., & Finkelstein, J. A. (1990) · Endocrinology · doi:10.1210/endo-127-6-3087 · Cited by 72 · see citing works
Self-citation
Growth hormone binding protein in the rat: effects of gonadal steroids
Carmignac, D. F., Gabrielsson, B. G., & Robinson, I. C. A. F. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243263 · Cited by 68 · see citing works

Authors: FINKELSTEIN, J. W., ROFFWARG, H. P., BOYAR, R. M., KREAM, J., & HELLMAN, L.
Affiliations: Montefiore Medical Center (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1972-11
Volume: 35
Issue: 5
Pages: 665-670
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-35-5-665
OpenAlex: W1997993870
Cited by: 640
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 13
FWCI: 7.61
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords: growth hormone secretion, age-related changes, prepubertal children, adolescents, young adults, older adults
MeSH terms: Adolescent, Adult, Age Factors, Child, Circadian Rhythm, Female, Humans, Male, Middle Aged, Secretory Rate, Sleep Stages, Growth Hormone, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Age-related change in the twenty-four-hour spontaneous secretion of growth hormone

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cited by

Related

Record

About these checks