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Cited by 241Reproductive Health and ContraceptionBone health and osteoporosis researchHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

A prospective comparison of bone density in adolescent girls receiving depot medroxyprogesterone acetate (Depo-Provera), levonorgestrel (Norplant), or oral contraceptives.

Cromer, Barbara A., Blair, Jamie McArdle, Mahan, John D., Zibners, Lara, Naumovski, Zoran·1996·The Journal of Pediatrics
DOI 10.1016/s0022-3476(96)70148-8
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Abstract

Objective To examine bone density among adolescents receiving different forms of hormonal contraception along with that of control subjects.Methods Baseline and 1-year measures of lumbar vertebral bone density were obtained in girls receiving depot medroxyprogesterone acetate (Depo-Provera) (n = 15), levonorgestrel (Norplant) (n = 7), or oral contraceptives (n = 9) and in girls receiving no hormonal treatment (n = 17). In a subsample of Depo-Provera users (n = 8), Norplant users (n = 3), and control subjects (n = 4), bone density measurements were repeated after 2 years. Bone density was measured by dual-energy x-ray absorptiometry.Results Body mass indexes, level of pubertal development, substance use, and reproductive histories were not significantly different among the groups. More black girls were represented in the initial Depo-Provera group (p < 0.02), girls in the Norplant group exercised more hours per week (p < 0.02), and control subjects were older (p < 0.01) than those in the other groups. These variables did not significantly affect bone density results. After 1 year, bone density decreased 1.5% in Depo-Provera users, compared with increases of 2.5% in Norplant users, 1.5% in oral contraceptive users, and 2.9% control subjects (p < 0.02). After 2 years, bone density increased a total of 9.3% in Norplant users and 9.5% in control subjects but decreased a total of 3.1% in Depo-Provera users (p < 0.0001).Conclusion These data suggest that Depo-Provera may, at least temporarily, suppress the expected skeletal bone mineralization in adolescents, whereas Norplant and oral contraceptives are associated with the expected increase in bone density in this population.

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Crossref · 10.1016/s0022-3476(96)70148-8

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Metadata

Authors
Cromer, B. A., Blair, J. M., Mahan, J. D., Zibners, L., & Naumovski, Z.
Affiliations
  • The Ohio State University (US)
  • Nationwide Children's Hospital (US)
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
1996-11
Volume
129
Issue
5
Pages
671-676
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/s0022-3476(96)70148-8
OpenAlex
W1995449031
Cited by
241
References
27
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 8 · 2013: 4 · 2012: 5
FWCI
12.79
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
bone mineral density, hormonal contraception, depot medroxyprogesterone acetate, levonorgestrel, oral contraceptives, adolescent girls, lumbar spine, bone mineralization, pubertal development, body mass index
MeSH terms
Adolescent, Adult, Contraceptive Agents, Female, Contraceptives, Oral, Female, Humans, Prospective Studies, Bone Density, Case-Control Studies, Levonorgestrel, Medroxyprogesterone Acetate

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