Cited by 241Reproductive Health and ContraceptionBone health and osteoporosis researchHypothalamic control of reproductive hormones

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A prospective comparison of bone density in adolescent girls receiving depot medroxyprogesterone acetate (Depo-Provera), levonorgestrel (Norplant), or oral contraceptives.

Cromer, Barbara A., Blair, Jamie McArdle, Mahan, John D., Zibners, Lara, Naumovski, Zoran·1996·The Journal of Pediatrics

DOI 10.1016/s0022-3476(96)70148-8

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Abstract

Objective To examine bone density among adolescents receiving different forms of hormonal contraception along with that of control subjects.Methods Baseline and 1-year measures of lumbar vertebral bone density were obtained in girls receiving depot medroxyprogesterone acetate (Depo-Provera) (n = 15), levonorgestrel (Norplant) (n = 7), or oral contraceptives (n = 9) and in girls receiving no hormonal treatment (n = 17). In a subsample of Depo-Provera users (n = 8), Norplant users (n = 3), and control subjects (n = 4), bone density measurements were repeated after 2 years. Bone density was measured by dual-energy x-ray absorptiometry.Results Body mass indexes, level of pubertal development, substance use, and reproductive histories were not significantly different among the groups. More black girls were represented in the initial Depo-Provera group (p < 0.02), girls in the Norplant group exercised more hours per week (p < 0.02), and control subjects were older (p < 0.01) than those in the other groups. These variables did not significantly affect bone density results. After 1 year, bone density decreased 1.5% in Depo-Provera users, compared with increases of 2.5% in Norplant users, 1.5% in oral contraceptive users, and 2.9% control subjects (p < 0.02). After 2 years, bone density increased a total of 9.3% in Norplant users and 9.5% in control subjects but decreased a total of 3.1% in Depo-Provera users (p < 0.0001).Conclusion These data suggest that Depo-Provera may, at least temporarily, suppress the expected skeletal bone mineralization in adolescents, whereas Norplant and oral contraceptives are associated with the expected increase in bone density in this population.

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Authors: Cromer, B. A., Blair, J. M., Mahan, J. D., Zibners, L., & Naumovski, Z.
Affiliations: The Ohio State University (US)
Nationwide Children's Hospital (US)
ORCID: Mahan, John D.
Zibners, Lara
Venue: The Journal of Pediatrics
Publisher: Elsevier BV
Published: 1996-11
Volume: 129
Issue: 5
Pages: 671-676
ISSN: 0022-3476 (ISSN-L)
DOI: 10.1016/s0022-3476(96)70148-8
OpenAlex: W1995449031
Cited by: 241
References: 27
Citations by year: 2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 8 · 2013: 4 · 2012: 5
FWCI: 12.79
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Pediatrics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: bone mineral density, hormonal contraception, depot medroxyprogesterone acetate, levonorgestrel, oral contraceptives, adolescent girls, lumbar spine, bone mineralization, pubertal development, body mass index
MeSH terms: Adolescent, Adult, Contraceptive Agents, Female, Contraceptives, Oral, Female, Humans, Prospective Studies, Bone Density, Case-Control Studies, Levonorgestrel, Medroxyprogesterone Acetate

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A prospective comparison of bone density in adolescent girls receiving depot medroxyprogesterone acetate (Depo-Provera), levonorgestrel (Norplant), or oral contraceptives.

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