Analgesic, Respiratory and Heart Rate Effects of Cannabinoid and Opioid Agonists in Rhesus Monkeys: Antagonist Effects of SR 141716A
Abstract
This study characterized the antinociceptive, respiratory and heart rate effects of the cannabinoid receptor agonists Delta-9-tetrahydrocannabinol (Delta-9-THC) and WIN 55212 ((R)-(+)-2, 3-dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrol-[1,2,3-de]-1, 4-benzoxazin-6-yl)(1-naphtalenyl)methanone monomethanesulfonate), N-arachidonyl ethanolamide (anandamide) and the mu and kappa opioid receptor agonists heroin and U69593, alone and in conjunction with a cannabinoid receptor antagonist, SR 141716A [N-(piperidin-1-1-yl)-5-(4-chlorophenyl)-1(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride] and an opioid receptor antagonist, quadazocine, in rhesus monkeys (Macaca mulatta). Using 12 adult rhesus monkeys, latencies to remove the tail from a 50 degrees C water bath, respiration in 5% CO2 and heart rate were measured. When administered alone, SR 141716A (1.8, 5.6 mg/kg i.m.) did not alter nociception, respiration or heart rate. Delta-9-THC (0.1-10 mg/kg i.m.) and WIN 55212 (0.1-10 mg/kg i.m.) dose-dependently increased antinociception and dose-dependently decreased respiratory minute and tidal volumes and heart rate. These antinociceptive, respiratory and heart rate effects were reversed by SR 141716A but not by the opioid antagonist quadazocine (1 mg/kg i.m.). Anandamide (10 mg/kg i.m.) also produced antinociception. Heroin (0.01-10 mg/kg i.m.) and U69593 (0.01-3.2 mg/kg i.m.) also dose-dependently increased antinociception and decreased respiratory and heart rate measures; these effects were antagonized by quadazocine but not by SR 141716A. These results demonstrate selective and reversible antagonism of cannabinoid behavioral effects by SR 141716A in rhesus monkeys.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the rhesus monkey warm water tail withdrawal paradigm, AEA, THC, and WIN55,212-2 produce dose-dependent antinociceptive effects.
“In the rhesus monkey warm water tail withdrawal paradigm, the endogenous cannabinoid arachidonoylethanolamine (anandamide; AEA), the primary active constituent of cannabis Δ 9 -tetrahydrocannabinol (THC), and the high efficacy synthetic cannabinoid receptor agonist WIN55,212-2 produce dose-dependent antinociceptive effects (Manning et al, 2001;Vivian et al, 1998).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Vivian et al, 1998
Cites
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
Rinaldi, M. L., Barth, F., Héaulme, M., Shire, D. J., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00773-x · Cited by 1,751 · see citing works
Cardiovascular effects of anemia
Varat, M. A., Adolph, R. J., & Fowler, N. O. (1972) · American Heart Journal · doi:10.1016/0002-8703(72)90445-0 · Cited by 431 · see citing works
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.
Smith, P. B., Compton, D. M., Welch, S. P., Razdan, R. K., Mechoulam, R., & Martin, B. R. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22356-4 · Cited by 394 · see citing works
Compton, D. M., Aceto, M. D. G., Lowe, J. A., III, & Martin, B. R. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12911-x · Cited by 357 · see citing works
Herzberg, U., Eliav, E., Bennett, G. J., & Kopin, I. J. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13308-5 · Cited by 307 · see citing works
Rinaldi, M. L., Barth, F., Héaulme, M., Alonso, R., Shire, D. J., Congy, C., Soubrié, P., Brelière, J.-C., & Fur, G. L. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00174-5 · Cited by 303 · see citing works
Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR 141716
Terranova, J.-P., Storme, J.-J., Lafon, N., Perio, A., Rinaldi, M. L., Fur, G. L., & Soubrié, P. (1996) · Psychopharmacology · doi:10.1007/bf02246352 · Cited by 283 · see citing works
Δ9-Tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism
Lichtman, A. H., & Martin, B. R. (1996) · Psychopharmacology · doi:10.1007/bf02246347 · Cited by 213 · see citing works
Welch, S. P., & Stevens, D. L. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10720-9 · Cited by 208 · see citing works
Tsou, K., Patrick, S. L., & Walker, J. M. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00360-w · Cited by 173 · see citing works
Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal.
Aceto, M. D. G., Scates, S. M., Lowe, J. A., III, & Martin, B. R. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20781-9 · Cited by 168 · see citing works
Rinaldi, M. L., Pialot, F., Congy, C., Redon, E., Barth, F., Bachy, A., Brelière, J.-C., Soubrié, P., & Fur, G. L. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00085-9 · Cited by 132 · see citing works
Development of cross-tolerance between delta 9-tetrahydrocannabinol, CP 55,940 and WIN 55,212.
Fan, F., Compton, D. M., Ward, S. J., Melvin, L. S., & Martin, B. R. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24023-x · Cited by 126 · see citing works
Wiley, J. L., Lowe, J. A., III, Balster, R. L., & Martin, B. R. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12022-3 · Cited by 126 · see citing works
Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats
Wiley, J. L., Barrett, R. L., Lowe, J. A., III, Balster, R. L., & Martin, B. R. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00027-4 · Cited by 122 · see citing works
Regional Cerebral Blood Flow after Marijuana Smoking
Mathew, R. J., Wilson, W. H., Humphreys, D. F., Lowe, J. V., & Wiethe, K. E. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.106 · Cited by 112 · see citing works
Selley, D. E., Stark, S., Sim, L. J., & Childers, S. R. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00347-5 · Cited by 111 · see citing works
Reche, I., Fuentes, J. A., & Ruiz-Gayo, M. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00752-2 · Cited by 87 · see citing works
A tail withdrawal procedure for assessing analgesic activity in rhesus monkeys
Dykstra, L., & Woods, J. H. (1986) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(86)90056-2 · Cited by 84 · see citing works
Self-citationPugh, G., Mason, D. J., Combs, V., & Welch, S. P. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36640-6 · Cited by 81 · see citing works
Welch, S. P., Dunlow, L. D., Patrick, G., & Razdan, R. K. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09617-x · Cited by 79 · see citing works
Discriminative stimulus effects of anandamide in rats
Wiley, J. L., Balster, R. L., & Martin, B. R. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00010-i · Cited by 74 · see citing works
Wiley, J. L., Huffman, J. W., Balster, R. L., & Martin, B. R. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(95)01193-5 · Cited by 70 · see citing works
Reche, I., Fuentes, J. A., & Ruiz‐Gayo, M. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00045-3 · Cited by 64 · see citing works
Intravenous Δ9-Tetrahydrocannabinol
Malit, L. A., Johnstone, R. E., Bourke, D. L., Kulp, R. A., Klein, V., & Smith, T. C. (1975) · Anesthesiology · doi:10.1097/00000542-197506000-00008 · Cited by 58 · see citing works
Cardiovascular Effects of (-)-11-OH-Δ8-Tetrahydrocannabinol-Dimethylheptyl in Rats
Vidrio, H., Sánchez‐Salvatori, M. A., & Medina, M. (1996) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199608000-00022 · Cited by 56 · see citing works
Preference for high- versus low-potency marijuana
Chait, L. D., & Burke, K. A. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90082-5 · Cited by 52 · see citing works
Cannabinoids. I. Behavioral effects.
Stark, P., & DEWS, P. B. (1980) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32141-5 · Cited by 51 · see citing works
Combination of Δ9-Tetrahydrocannabinol with Oxymorphone or Pentobarbital
Johnstone, R. E., Lief, P. L., Kulp, R. A., & Smith, T. C. (1975) · Anesthesiology · doi:10.1097/00000542-197506000-00009 · Cited by 45 · see citing works
Howell, L. L., Bergman, J., & Morse, W. H. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22291-1 · Cited by 45 · see citing works
Pugh, G., Abood, M. E., & Welch, S. P. (1995) · Brain Research · doi:10.1016/0006-8993(95)00560-d · Cited by 33 · see citing works
Hine, B. (1985) · Psychopharmacology · doi:10.1007/bf00431774 · Cited by 31 · see citing works
Cardiovascular effects of Δ9- andΔ9(11)-tetrahydrocannabinol and their interaction with epinephrine
Estrada-Robles, U., Brase, D. A., Martin, B. R., & Dewey, W. L. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90559-5 · Cited by 27 · see citing works
Fredericks, A., Benowitz, N. L., & Savanapridi, C. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32409-2 · Cited by 25 · see citing works
Response to marijuana as a function of potency and breathhold duration
Zacny, J. P., & Chait, L. D. (1991) · Psychopharmacology · doi:10.1007/bf02244207 · Cited by 24 · see citing works
Blockade of cannabinoid-induced antinociception by naloxone benzoylhydrazone (NalBZH)
Welch, S. P. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90245-3 · Cited by 21 · see citing works
Δ9-Tetrahydrocannabinol: EEG changes, bradycardia and hypothermia in the rhesus monkey
Matsuzaki, M., Casella, G. A., & Ratner, M. (1987) · Brain Research Bulletin · doi:10.1016/0361-9230(87)90087-6 · Cited by 18 · see citing works
Hine, B., Torrelio, M., & Gershon, S. (2008) · Pharmacology · doi:10.1159/000136664 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The effects of cannabinoids on the brain
Ameri, A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00087-2 · Cited by 805 · see citing works
Cannabinoid receptors and pain
Pertwee, R. G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00031-9 · Cited by 741 · see citing works
Pharmacological and biochemical interactions between opioids and cannabinoids
Manzanares, J., Corchero, J., Romero, J., Fernández‐Ruíz, J., Ramos, J. A., & Fuentes, J. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01339-5 · Cited by 391 · see citing works
The Endocannabinoid System: Drug Targets, Lead Compounds, and Potential Therapeutic Applications
Lambert, D. M., & Fowler, C. J. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm058183t · Cited by 350 · see citing works
Direct inhibition of T‐type calcium channels by the endogenous cannabinoid anandamide
Chemin, J., Monteil, A., Perez‐Reyes, E., Nargeot, J., & Lory, P. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7033 · Cited by 299 · see citing works
Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works
Motivational Effects of Cannabinoids Are Mediated by μ-Opioid and κ-Opioid Receptors
Ghozland, S. G., Matthes, H. W. D., Simonin, F., Filliol, D., Kieffer, B. L., & Maldonado, R. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-01146.2002 · Cited by 263 · see citing works
The Endomorphin System and Its Evolving Neurophysiological Role
Fichna, J., Janecka, A. E., Costentin, J., & do-Rego, J.-C. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.1.3 · Cited by 249 · see citing works
Boggs, D. L., Nguyen, J. D., Morgenson, D., Taffe, M. A., & Ranganathan, M. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.209 · Cited by 236 · see citing works
Naef, M., Curatolo, M., Petersen-Felix, S., Arendt-Nielsen, L., Zbinden, A., & Brenneisen, R. (2003) · Pain · doi:10.1016/s0304-3959(03)00163-5 · Cited by 209 · see citing works
Cannabinoid Mechanisms of Pain Suppression
Walker, J. M., & Hohmann, A. G. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-26573-2_17 · Cited by 177 · see citing works
Sex differences in antinociceptive and motoric effects of cannabinoids.
Tseng, A. H., & Craft, R. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01267-5 · Cited by 156 · see citing works
Morisset, V., & Urbán, L. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.40 · Cited by 152 · see citing works
Self-administration of cannabinoids by experimental animals and human marijuana smokers
Justinová, Z., Goldberg, S. R., Heishman, S. J., & Tanda, G. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.026 · Cited by 137 · see citing works
Molecular biology of cannabinoid receptors
Lutz, B. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0342 · Cited by 135 · see citing works
Therapeutic Utility of Cannabinoid Receptor Type 2 (CB2) Selective Agonists
Han, S., Thatte, J., Buzard, D. J., & Jones, R. M. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm4005626 · Cited by 134 · see citing works
Antinociceptive, subjective and behavioral effects of smoked marijuana in humans
Greenwald, M. K., & Stitzer, M. L. (2000) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(99)00128-3 · Cited by 119 · see citing works
Tanda, G., Munzar, P., Goldberg, S. R., & Justinova, Z. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1693-6 · Cited by 111 · see citing works
Cannabinoids modulate pain by multiple mechanisms of action
Richardson, J. D. (2000) · The Journal of Pain · doi:10.1016/s1526-5900(00)90082-8 · Cited by 109 · see citing works
The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice
Shafaroodi, H., Samini, M., Moezi, L., Homayoun, H., Sadeghipour, H., Tavakoli, S., Hajrasouliha, A. R., & Dehpour, A. R. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.04.011 · Cited by 105 · see citing works
Niederhoffer, N., Schmid, K., & Szabó, B. (2003) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-003-0755-y · Cited by 100 · see citing works
Δ9-Tetrahydrocannabinol inhibits gastric motility in the rat through cannabinoid CB1 receptors
Krowicki, Z. K., Moerschbaecher, J. M., Winsauer, P. J., Sivarao, D. V., & Hornby, P. J. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00165-x · Cited by 94 · see citing works
Vaccarino, A. L., Olson, G. A., Olson, R. D., & Kastin, A. J. (1999) · Peptides · doi:10.1016/s0196-9781(99)00166-7 · Cited by 89 · see citing works
Manning, B. H., Merin, N. M., Meng, I. D., & Amaral, D. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08238.2001 · Cited by 88 · see citing works
Endocannabinoids in cerebrovascular regulation
Benyó, Z., Ruisanchez, É., Leszl-Ishiguro, M., Sándor, P., & Pacher, P. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00571.2015 · Cited by 87 · see citing works
Possible mechanisms of cannabinoid-induced antinociception in the spinal cord
Morisset, V., Ahluwalia, J. P., Nagy, I., & Urbán, L. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01309-7 · Cited by 86 · see citing works
Interaction between naltrexone and oral THC in heavy marijuana smokers
Haney, M., Bisaga, A. M., & Foltin, R. W. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1279-8 · Cited by 83 · see citing works
Marijuana Withdrawal Syndrome in the Animal Model
Lichtman, A. H., & Martin, B. R. (2002) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.2002.tb05999.x · Cited by 78 · see citing works
Cannabinoids as potential new analgesics
Fuentes, J., Ruiz‐Gayo, M., Manzanares, J., Vela, G., Reche, I., & Corchero, J. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00290-8 · Cited by 72 · see citing works
Maguire, D. R., Yang, W., & France, C. P. (2013) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.204099 · Cited by 71 · see citing works
Pfitzer, T., Niederhoffer, N., & Szabó, B. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705874 · Cited by 68 · see citing works
Butelman, E. R., Prisinzano, T. E., Deng, H., Rus, S., & Kreek, M. J. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.145342 · Cited by 66 · see citing works
Self-citationA Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors
Xiong, W., Wu, X., Lovinger, D. M., & Li, Z. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6347-11.2012 · Cited by 62 · see citing works
Maguire, D. R., & France, C. P. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.216648 · Cited by 59 · see citing works
Ko, M., & Woods, J. H. (1999) · Psychopharmacology · doi:10.1007/s002130050955 · Cited by 58 · see citing works
Self-citationAnalysis of the respiratory effects of cannabinoids in rats
Schmid, K., Niederhoffer, N., & Szabó, B. (2003) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-003-0787-3 · Cited by 54 · see citing works
Fosgerau, K., Weber, U. J., Gotfredsen, J. W., Jayatissa, M. N., Buus, C., Kristensen, N. B., Vestergaard, M., Teschendorf, P., Schneider, A., Hansen, P., et al. (2010) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-10-51 · Cited by 47 · see citing works
Cannabinoids, endogenous ligands and synthetic analogs
Pop, E. (1999) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(99)80062-3 · Cited by 45 · see citing works
Stewart, J. L., & McMahon, L. R. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.168435 · Cited by 43 · see citing works
Role of Cannabinoid Receptor in the Brain as It Relates to Drug Reward
Yamamoto, T., & Takada, K. (2000) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.84.229 · Cited by 41 · see citing works
Amorós, I., Barana, A., Caballero, R., Gómez, R. J., Osuna, L., Lillo, M. P., Tamargo, J. L., & Delpón, E. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.07.011 · Cited by 40 · see citing works
Weresa, J., Pędzińska‐Betiuk, A., Mińczuk, K., Malinowska, B., & Schlicker, E. (2022) · Cells · doi:10.3390/cells11071142 · Cited by 36 · see citing works
Synthesis and CB1 cannabinoid receptor affinity of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles
Shu, H., Izenwasser, S., Wade, D., Stevens, E. D., & Trudell, M. L. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.11.110 · Cited by 36 · see citing works
Interactions between Δ9-tetrahydrocannabinol and heroin
Li, J., Koek, W., & France, C. P. (2012) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32835a3907 · Cited by 36 · see citing works
Sadhasivam, S., Zhang, X., Chidambaran, V., Mavi, J., Pilipenko, V. V., Baye, T. M., Meller, J., Kaufman, K. M., Martin, L. J., & McAuliffe, J. J. (2015) · The Pharmacogenomics Journal · doi:10.1038/tpj.2014.79 · Cited by 36 · see citing works
Modulation of T-type calcium channels by bioactive lipids
Chemin, J., Cazade, M., & Lory, P. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1467-5 · Cited by 35 · see citing works
Mostafeezur, R. M., Zakir, H. M., Takatsuji, H., Yamada, Y., Yamamura, K., & Kitagawa, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050703 · Cited by 31 · see citing works
SR 141716A differentially attenuates the behavioral effects of ??9-THC in rhesus monkeys
McMahon, L. R., Amin, M. R., & France, C. P. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00008 · Cited by 30 · see citing works
Focus on the Three Key Enzymes Hydrolysing Endocannabinoids as New Drug Targets
Vandevoorde, S., & Lambert, D. M. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612054546914 · Cited by 26 · see citing works
Ultra-low dose naltrexone enhances cannabinoid-induced antinociception
Paquette, J. J., & Olmstead, M. C. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200512000-00001 · Cited by 26 · see citing works
Gerak, L. R., Maguire, D. R., Woods, J. H., Husbands, S. M., Disney, A., & France, C. P. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.253286 · Cited by 26 · see citing works
Self-citationCross-tolerance to cannabinoids in morphine-tolerant rhesus monkeys
Gerak, L. R., Zanettini, C., Koek, W., & France, C. P. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4023-x · Cited by 25 · see citing works
Operant nociception in nonhuman primates
Kangas, B. D., & Bergman, J. (2014) · Pain · doi:10.1016/j.pain.2014.06.010 · Cited by 22 · see citing works
Weed, P. F., Gerak, L. R., & France, C. P. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.05.041 · Cited by 21 · see citing works
McMahon, L. R. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1230-8 · Cited by 21 · see citing works
Cannabinoid receptor expression in peripheral arterial chemoreceptors during postnatal development
McLemore, G. L., Cooper, R., Richardson, K. A., Mason, A. V., Marshall, C., Northington, F. J., & Gauda, E. B. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00378.2004 · Cited by 20 · see citing works
Freedland, C. S., Whitlow, C. T., Smith, H. R., & Porrino, L. J. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03999-9 · Cited by 18 · see citing works
Negus, S. S., Brandt, M. R., Gatch, M. B., & Mello, N. K. (2003) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(02)00331-9 · Cited by 17 · see citing works
Efficacy of cannabinoids in fibromyalgia: a literature review
Anaya, H. J. M., Ortiz, M. P. T., Valencia, D. H. F., & Ribero, O. F. G. (2021) · Colombian Journal of Anesthesiology · doi:10.5554/22562087.e980 · Cited by 13 · see citing works
The Contribution of cocoa additive to cigarette smoking addiction
Rambali, B., van, A. I., Schenk, E., Wolterink, G., van de, W. G., Stevenson, H. A., & Vleeming, W. (2003) · Rivm Repository (Netherlands National Institute for Public Health and the Environment) · Cited by 13 · see citing works
Gene Therapy for the Management of Pain
Wu, C. L., Garry, M. G., Zollo, R. A., & Yang, J. (2001) · Anesthesiology · doi:10.1097/00000542-200107000-00033 · Cited by 13 · see citing works
Zenor, B. N., Weesner, G. D., & Malven, P. V. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00229-5 · Cited by 12 · see citing works
Identification of the role of endogenous cannabinoids in pain modulation: strategies and pitfalls
Walker, J. M., Huang, S. M., Strangman, N. M., & Sañudo-Peña, M. C. (2000) · Journal of Pain · doi:10.1016/s1526-5900(00)90085-3 · Cited by 12 · see citing works
CB1 receptor-mediated respiratory depression by endocannabinoids
Iring, A., Hricisák, L., & Benyó, Z. (2017) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2017.02.011 · Cited by 12 · see citing works
CB1 cannabinoid receptor agonists induce acute respiratory depression in awake mice
Watkins, J. M., Aradi, P., Hahn, R., Makriyannis, A., Mackie, K., Katona, I., & Hohmann, A. G. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107682 · Cited by 9 · see citing works
The Development of Cannabinoids as Therapeutic Agents in the United States
Murray, C. H., Gannon, B. M., Winsauer, P. J., Cooper, Z. D., & Delatte, M. S. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.123.001121 · Cited by 9 · see citing works
Kaufman, M. J., Janes, A. C., Frederick, B. B., Brimson-Théberge, M., Tong, Y., McWilliams, S. B., Bear, A., Gillis, T. E., Schrode, K. M., Renshaw, P. F., et al. (2013) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0033062 · Cited by 8 · see citing works
Behavioral Pharmacology of Drugs Acting at Mu Opioid Receptors
Gerak, L. R., Maguire, D. R., & France, C. P. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_265 · Cited by 8 · see citing works
Cannabinoid CB 2 Receptor Activation Attenuates Fentanyl-Induced Respiratory Depression
Zavala, C. A., Thomaz, A. C., Iyer, V., Mackie, K., & Hohmann, A. G. (2020) · Cannabis and Cannabinoid Research · doi:10.1089/can.2020.0059 · Cited by 7 · see citing works
Leff, P., Herrera, N., Matus-Ortega, M., Romero, L. P., Santillán, C. T., Juárez, A., & Palma, B. A. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 7 · see citing works
James, J. C., Thrush, J. R., Yusufali, T. M., Shaw, H. E., Avram, M., Moran, J. H., & Fantegrossi, W. E. (2025) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2025.112672 · Cited by 6 · see citing works
Galaj, E., Bi, G., & Xi, Z. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109947 · Cited by 6 · see citing works
Krylatov, A. V., Маслов, Л. Н., Nam, I., & Bushov, Y. V. (2019) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-019-00736-w · Cited by 6 · see citing works
Functional role for preoptic CB1 receptors in breathing and thermal control
Ripamonte, G. C., Bernardes-Ribeiro, M., Patrone, L. G. A., Vicente, M. C., Bícego, K. C., & Gargaglioni, L. H. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135021 · Cited by 6 · see citing works
Clarke, R. W., Harris, J. E., Jenkins, S., & Witton, S. K. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00179-9 · Cited by 6 · see citing works
Laudermilk, L. T., Marusich, J. A., & Wiley, J. L. (2023) · Cardiovascular Toxicology · doi:10.1007/s12012-023-09810-9 · Cited by 5 · see citing works
Morris, T. M., Cucinello‐Ragland, J. A., Marks, T. J., Prevost, K., Glenn, J. F., Davenport, G. J., Edwards, S., & Winsauer, P. J. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173692 · Cited by 5 · see citing works
39th Annual European Brain and Behaviour Society Abstracts
Treves, E. B. A., Battaglini, P. P., Chelazzi, L., Diamond, M. E., & Vallortigara, G. (2007) · Neural Plasticity · doi:10.1155/2007/23250 · Cited by 5 · see citing works
Opioid System Involvement in Cannabinoid Tolerance and Dependence
Maldonado, R. J. (1882) · Humana Press eBooks · doi:10.1007/978-1-59259-343-9_12 · Cited by 5 · see citing works
Carey, L. M., Galbo, L. K., Maguire, D. R., & France, C. P. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103671 · Cited by 4 · see citing works
Supranodose vagotomy eliminates anandamide-evoked cardiorespiratory depression in anaesthetized rats
Kopczyńska, B., & Szereda‐Przestaszewska, M. (2005) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2005.07.007 · Cited by 4 · see citing works
Targeting G protein coupled receptors for alleviating neuropathic pain
Kumari, P., Yadav, A., Patel, M., & Yadav, P. N. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.06.004 · Cited by 3 · see citing works
Use of cannabis in medicine and pharmacy
Goločorbin-Kon, S., Pavlović, N., Rašković, A., Lalic-Popovic, M. N., Milić, N., Milosevic, N. P., & Mikov, M. (2015) · Medicinski casopis · doi:10.5937/mckg49-9796 · Cited by 3 · see citing works
DOSE-DEPENDENT EFFECTS ON VENTILATION AT REST INDUCED BY HIGH DOSES OF CANNABINOIDS IN RATS
Duarte, T., Houzé, P., Risède, P., Pope, C., Scherrmann, J., & Baud, F. J. (2010) · Acta Clinica Belgica · doi:10.1179/acb.2010.115 · Cited by 1 · see citing works
Jones, J. D., Luba, R. R., Mumtaz, M., & Castillo, F. (2023) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197618431.013.30 · Cited by 1 · see citing works
The Effects of Synthetic Cannabinoids on Alveolar-Arterial Oxygen Gradient
Küçük, E. (2016) · The Annals of Clinical and Analytical Medicine · doi:10.4328/jcam.3153 · Cited by 1 · see citing works
Respiratorische Insuffizienz durch Delta-9-Tetrahydrocannabinol bei tetraplegischem Patienten
Neuburger, M., Schley, M. T., Schmelz, M., Schuepfer, G., & Konrad, C. J. (2006) · Der Schmerz · doi:10.1007/s00482-006-0474-7
Ford, B. (2010) · Scholars Commons (Wilfrid Laurier University)
Synthesis of Dibenzofurans via a Palladium Catalyzed Oxidative Ring Closure Reaction
Akram, S. (2013) · ScholarWorks @ The University of New Orleans (The University of New Orleans)
Cannabinoid modulation of nociception and nociceptor activity during inflammation.
Potenzieri, C. (2009) · University of Minnesota Digital Conservancy (University of Minnesota)
CANNABINOIDERGIC REGULATION OF FUNCTIONAL STATE OF HEART (PART I)
Krylatov, A. V., Serebrov, V. Y., Ваизова, О. Е., & Dyakova, E. Y. (2017) · Сибирский журнал клинической и экспериментальной медицины · doi:10.29001/2073-8552-2017-32-3-7-13
de Freitas, & Alyson, L. (2020)
Effets comportementaux des cannabinoïdes Données animales
Thiébot, M.-H., & Chaperon, F. (2001) · Douleur et Analgésie · doi:10.1007/bf03012691
Feller, D. (2007) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.62830-2
- Authors
- Vivian, J. A., Kishioka, S., Butelman, E. R., Broadbear, J., Lee, K. O., & Woods, J. H.
- Affiliations
- University of Michigan (US)
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 286
- Issue
- 2
- Pages
- 697-703
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2101889344
- Cited by
- 98
- References
- 38
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Journal of Pharmacology and Experimental Therapeutics
- Funders
- National Institute on Drug Abuse (DA05773, DA-07268, T32DA007268, DA-00254)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cannabinoid receptor agonists, opioid agonists, antinociception, analgesia, respiratory depression, heart rate, SR141716A, rimonabant, cannabinoid receptor antagonists, opioid antagonists, delta-9-tetrahydrocannabinol, anandamide, heroin, U69593
- MeSH terms
- Rimonabant, Analgesics, Opioid, Animals, Cannabinoids, Heroin, Dose-Response Relationship, Drug, Hallucinogens, Heart Rate, Macaca mulatta, Morpholines, Naphthalenes, Pain Measurement, Piperidines, Pyrazoles, Pyrrolidines, Receptors, Drug, Receptors, Opioid, Dronabinol, Respiratory Mechanics, Receptors, Cannabinoid, Benzeneacetamides, Benzoxazines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review