The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376 · see citing works

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155 · see citing works

Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve

Tal, M., & Bennett, G. J. (1994) · Pain · doi:10.1016/0304-3959(94)90013-2 · Cited by 436 · see citing works

Biochemical and pharmacological characterisatioN OF SR141716A, the first potent and selective brain cannabinoid receptor antagonist

Rinaldi, M. L., Barth, F., Héaulme, M., Alonso, R., Shire, D. J., Congy, C., Soubrié, P., Brelière, J.-C., & Fur, G. L. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00174-5 · Cited by 303 · see citing works

Conformationally restrained analogs of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor

D'Ambra, T. E., Estep, K. G., Bell, M. R., Eissenstat, M. A., Josef, K. A., Ward, S. J., Haycock, D. A., Baizman, E. R., & Casiano, F. M. (1992) · Journal of Medicinal Chemistry · doi:10.1021/jm00079a016 · Cited by 296 · see citing works

Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy

Mao, J., Price, D. D., Hayes, R. L., Lü, J., Mayer, D. J., & Frenk, H. (1993) · Brain Research · doi:10.1016/0006-8993(93)91368-3 · Cited by 238 · see citing works

Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat

Tal, M., & Bennett, G. J. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90058-s · Cited by 144 · see citing works

Modulation of cannabinoid-induced antinociception after intracerebroventricular versus intrathecal administration to mice: possible mechanisms for interaction with morphine.

Welch, S. P., Thomas, C., & Patrick, G. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24328-2 · Cited by 124 · see citing works

Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2

Hohmann, A. G., Martin, W. J., Tsou, K., & Walker, J. M. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00196-d · Cited by 121 · see citing works

Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate

Carlton, S. M., Lekan, H. A., Kim, S. H., & Chung, J. M. (1994) · Pain · doi:10.1016/0304-3959(94)90090-6 · Cited by 121 · see citing works

Suppression of experimetal autoimmune encephalomyelitis by cannabinoids

Wirguin, I., Mechoulam, R., Breuer, A., Schezen, E., Weidenfeld, J., & Brenner, T. (1994) · Immunopharmacology · doi:10.1016/0162-3109(94)90056-6 · Cited by 117 · see citing works

Neuropathic pain sensations are differentially sensitive to dextrorphan

Tal, M., & Bennett, G. J. (1994) · Neuroreport · doi:10.1097/00001756-199407000-00008 · Cited by 94 · see citing works

The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-Δ6-tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) attenuates receptor-mediated neurotoxicity in primary cultures of rat forebrain

Nadler, V., Mechoulam, R., & Sokolovsky, M. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90555-y · Cited by 52 · see citing works

Changes in body temperature after administration of antipyretics, LSD, Δ9-THC and related agents: II

Clark, W. G. (1987) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(87)80003-9 · Cited by 27 · see citing works

Further studies on the antinociceptive effects ofΔ acid

Doyle, S. A., BURSTEIN, S. H., Dewey, W. L., & Welch, S. P. (1990) · Inflammation Research · doi:10.1007/bf02003237 · Cited by 26 · see citing works

Descending control of pain

Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035 · see citing works

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077 · see citing works

Role of Endogenous Cannabinoids in Synaptic Signaling

Freund, T. F., Katona, I., & Piomelli, D. (2003) · Physiological Reviews · doi:10.1152/physrev.00004.2003 · Cited by 1,568 · see citing works

Cannabinoid receptors and pain

Pertwee, R. G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00031-9 · Cited by 741 · see citing works

Cannabis and the brain

Iversen, L. L. (2003) · Brain · doi:10.1093/brain/awg143 · Cited by 735 · see citing works

Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial

Abrams, D. I., Jay, C. A., Shade, S. B., Vizoso, H., Reda, H., Press, S., Kelly, M. E., Rowbotham, M. C., & Petersen, K. L. (2007) · Neurology · doi:10.1212/01.wnl.0000253187.66183.9c · Cited by 598 · see citing works

Inverse agonism and neutral antagonism at cannabinoid CB1 receptors

Pertwee, R. G. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.10.025 · Cited by 444 · see citing works

Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebo-controlled clinical trial

Nurmikko, T. J., Serpell, M. G., Hoggart, B., Toomey, P. J., Morlion, B. J., & Haines, D. (2007) · Pain · doi:10.1016/j.pain.2007.08.028 · Cited by 431 · see citing works

Cannabinoid CB ₂ receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain

Guindon, J., & Hohmann, A. G. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707531 · Cited by 423 · see citing works

The endocannabinoid system as a target for therapeutic drugs

Piomelli, D., Giuffrida, A., Calignano, A., & Rodrı́guez de Fonseca, F. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01482-6 · Cited by 421 · see citing works

An analgesia circuit activated by cannabinoids

Meng, I. D., Manning, B. H., Martin, W. J., & Fields, H. L. (1998) · Nature · doi:10.1038/26481 · Cited by 411 · see citing works

Mechanisms of neuropathic pain

Bridges, D., Thompson, S., & Rice, A. S. C. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.1.12 · Cited by 403 · see citing works

The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain

Fox, A., Kesingland, A., Gentry, C., McNair, K., Patel, S., Urban, L., & James, I. (2001) · Pain · doi:10.1016/s0304-3959(00)00474-7 · Cited by 379 · see citing works

Cannabinoids and Pain: New Insights From Old Molecules

Vučković, S., Srebro, D., Vujović, K. S., Vučetić, Č., & Prostran, M. S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01259 · Cited by 417 · see citing works

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear

Chhatwal, J. P., Davis, M., Maguschak, K. A., & Ressler, K. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300655 · Cited by 376 · see citing works

Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial

Berman, J. S., Symonds, C., & Birch, R. (2004) · Pain · doi:10.1016/j.pain.2004.09.013 · Cited by 362 · see citing works

The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain

Jaggar, S., Hasnie, F. S., Sellaturay, S., & Rice, A. S. C. (1998) · Pain · doi:10.1016/s0304-3959(98)00041-4 · Cited by 351 · see citing works

A randomized, placebo-controlled, crossover trial of cannabis cigarettes in neuropathic pain

Wilsey, B., Marcotte, T., Tsodikov, A., Millman, J., Bentley, H., Gouaux, B., & Fishman, S. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2007.12.010 · Cited by 327 · see citing works

Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside

Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works

Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons

Ahluwalia, J. P., Urbán, L., Capogna, M., Bevan, S., & Nagy, I. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00389-4 · Cited by 302 · see citing works

Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

Lichtman, A. H., Shelton, C. C., Advani, T., & Cravatt, B. F. (2004) · Pain · doi:10.1016/j.pain.2004.01.022 · Cited by 301 · see citing works

Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study

Hohmann, A. G., & Herkenham, M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00524-7 · Cited by 301 · see citing works

The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain

Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works

Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes

Manzanares, J., Julian, M., & Carrascosa, A. (2006) · Current Neuropharmacology · doi:10.2174/157015906778019527 · Cited by 287 · see citing works

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

Jayamanne, A., Greenwood, R., Mitchell, V. A., Aslan, S., Piomelli, D., & Vaughan, C. W. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706510 · Cited by 287 · see citing works

Cannabinoid CB1 Receptor Expression in Rat Spinal Cord

Farquhar-Smith, W. P., Egertová, M., Bradbury, E. J., McMahon, S. B., Rice, A. S. C., & Elphick, M. R. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0844 · Cited by 268 · see citing works

Efficacy of Dronabinol as an Adjuvant Treatment for Chronic Pain Patients on Opioid Therapy

Narang, S., Gibson, D., Wasan, A. D., Ross, E. L., Michna, E., Nedeljkovic, S. S., & Jamison, R. N. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2007.10.018 · Cited by 257 · see citing works

Therapeutic Potential of Cannabinoids in CNS Disease

Croxford, J. L. (2003) · CNS Drugs · doi:10.2165/00023210-200317030-00004 · Cited by 240 · see citing works

Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats

Petrosino, S., Palazzo, E., de Novellis, V., Bisogno, T., Rossi, F., Maione, S., & Di Marzo, V. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.08.011 · Cited by 227 · see citing works

The synthetic cannabinoid WIN55,212‐2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain

Bridges, D., Ahmad, K., & Rice, A. S. C. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704110 · Cited by 221 · see citing works

Cannabis in cancer care

Abrams, D., & Guzmán, M. (2015) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.108 · Cited by 217 · see citing works

Pharmacological actions and therapeutic uses of cannabis and cannabinoids

Kumar, R., Chambers, W. A., & Pertwee, R. G. (2001) · Anaesthesia · doi:10.1046/j.1365-2044.2001.02269.x · Cited by 218 · see citing works

Medicinal Use of Cannabis: History and Current Status

Kalant, H. (2001) · Pain Research and Management · doi:10.1155/2001/469629 · Cited by 212 · see citing works

Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development

Pertwee, R. G. (2000) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.9.7.1553 · Cited by 228 · see citing works

Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain

Mitrirattanakul, S., Ramakul, N., Guerrero, A. V., Matsuka, Y., Ono, T., Iwase, H., Mackie, K., Faull, K. F., & Spigelman, I. (2006) · Pain · doi:10.1016/j.pain.2006.06.016 · Cited by 207 · see citing works

The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids

Pertwee, R. G. (2005) · The AAPS Journal · doi:10.1208/aapsj070364 · Cited by 204 · see citing works

The endogenous cannabinoid system and its role in nociceptive behavior

Cravatt, B. F., & Lichtman, A. H. (2004) · Journal of Neurobiology · doi:10.1002/neu.20080 · Cited by 203 · see citing works

Modulation of pain transmission by G-protein-coupled receptors

Pan, H., Wu, Z.-Z., Zhou, H.-Y., Chen, S.-R., Zhang, H., & Li, D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.003 · Cited by 197 · see citing works

Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats

Lim, G., Sung, B., Ji, R.-R., & Mao, J. (2003) · Pain · doi:10.1016/s0304-3959(03)00242-2 · Cited by 195 · see citing works

Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord

Hohmann, A. G., Briley, E. M., & Herkenham, M. A. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01321-3 · Cited by 183 · see citing works

Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy

Rice, A. S. C., Farquhar-Smith, W. P., & Nagy, I. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0362 · Cited by 183 · see citing works

Pharmacological characterization of the chronic constriction injury model of neuropathic pain

Vry, J. D., Kuhl, E., Franken‐Kunkel, P., & Eckel, G. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.03.051 · Cited by 184 · see citing works

Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependent Hyperalgesia

Richardson, J. D., Aanonsen, L., & Hargreaves, K. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00451.1998 · Cited by 182 · see citing works

Cannabinoid Mechanisms of Pain Suppression

Walker, J. M., & Hohmann, A. G. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-26573-2_17 · Cited by 177 · see citing works

Cannabinoid analgesia

Walker, J. M., & Huang, S. M. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00252-8 · Cited by 176 · see citing works

Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception

Ross, R. A., Coutts, A. A., McFarlane, S. M., Anavi-Goffer, S., Irving, A. J., Pertwee, R. G., MacEwan, D. J., & Scott, R. H. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00135-0 · Cited by 172 · see citing works

Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry

Bridges, D., Rice, A. S. C., Egertová, M., Elphick, M. R., Winter, J., & Michael, G. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00200-8 · Cited by 173 · see citing works

CB2 cannabinoid receptor mediation of antinociception

Ibrahim, M. M., Rude, M. L., Stagg, N. J., Mata, H. P., Lai, J. Y., Vanderah, T. W., Porreca, F., Buckley, N. E., Makriyannis, A., & Malan, P. T. (2006) · Pain · doi:10.1016/j.pain.2005.12.018 · Cited by 172 · see citing works

Cannabinoids: a real prospect for pain relief

Iversen, L. L. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00120-5 · Cited by 162 · see citing works

Spinal cannabinoids are anti-allodynic in rats with persistent inflammation

Martin, W. J., Loo, C. M., & Basbaum, A. I. (1999) · Pain · doi:10.1016/s0304-3959(99)00045-7 · Cited by 162 · see citing works

Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain

Jhaveri, M. D., Richardson, D., Kendall, D. A., Barrett, D. A., & Chapman, V. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3326-06.2006 · Cited by 159 · see citing works

Spinal and peripheral mechanisms of cannabinoid antinociception: behavioral, neurophysiological and neuroanatomical perspectives

Hohmann, A. G. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00154-8 · Cited by 159 · see citing works

Sex differences in antinociceptive and motoric effects of cannabinoids.

Tseng, A. H., & Craft, R. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01267-5 · Cited by 156 · see citing works

Characterization of Δ9-Tetrahydrocannabinol and Anandamide Antinociception in Nonarthritic and Arthritic Rats

Smith, F. L., Fujimori, K., Lowe, J., & Welch, S. P. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00583-2 · Cited by 154 · see citing works

Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats

Sagar, D. R., Kelly, S., Millns, P. J., O'Shaughnessey, C. T., Kendall, D. A., & Chapman, V. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04206.x · Cited by 154 · see citing works

Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin

Dvorak, M., Watkinson, A., McGlone, F. P., & Rukwied, R. (2003) · Inflammation Research · doi:10.1007/s00011-003-1162-z · Cited by 154 · see citing works

Cannabinoid-Induced Presynaptic Inhibition of Glutamatergic EPSCs in Substantia Gelatinosa Neurons of the Rat Spinal Cord

Morisset, V., & Urbán, L. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.40 · Cited by 152 · see citing works

Activation of cannabinoid CB₁ and CB₂ receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats

Rahn, E. J., Makriyannis, A., & Hohmann, A. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707333 · Cited by 146 · see citing works

Cannabis and its derivatives

Debbarma, G., & Acharya, P. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15489-8.00002-5 · Cited by 146 · see citing works

Strategies for the Treatment of Cancer Pain in the New Millennium

Ripamonti, C. I., & Dickerson, E. D. (2001) · Drugs · doi:10.2165/00003495-200161070-00005 · Cited by 136 · see citing works

Focal lysolecithin-induced demyelination of peripheral afferents results in neuropathic pain behavior that is attenuated by cannabinoids

Wallace, V. C. J., Cottrell, D. F., Brophy, P. J., & Fleetwood-Walker, S. M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03221.2003 · Cited by 134 · see citing works

The neurobiology of cannabinoid analgesia

Walker, J. M., Hohmann, A. G., Martin, W. J., Strangman, N. M., Huang, S. M., & Tsou, K. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00289-1 · Cited by 134 · see citing works

Photochemical Asymmetric Nickel‐Catalyzed Acyl Cross‐Coupling

Gandolfo, E., Tang, X., Roy, S. R., & Melchiorre, P. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201910168 · Cited by 131 · see citing works

Brain Cannabinoid Systems as Targets for the Therapy of Neurological Disorders

Consroe, P. F. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0220 · Cited by 129 · see citing works

Lack of Analgesia by Oral Standardized Cannabis Extract on Acute Inflammatory Pain and Hyperalgesia in Volunteers

Kraft, B., Frickey, N., Kaufmann, R. M., Reif, M., Frey, R., Gustorff, B., & Kress, H. G. (2008) · Anesthesiology · doi:10.1097/aln.0b013e31817881e1 · Cited by 129 · see citing works

Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat

Scott, D. A., Wright, C. E., & Angus, J. A. (2004) · Pain · doi:10.1016/j.pain.2004.01.020 · Cited by 128 · see citing works

Efficacy of two cannabis‐based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial

Berman, J. S., Lee, J., Cooper, M., Cannon, A., Sach, J., McKerral, S., Taggart, M., Symonds, C., Fishe, K., & Birch, R. (2003) · Anaesthesia · doi:10.1046/j.1365-2044.2003.03408_3.x · Cited by 122 · see citing works

Pre- and postsynaptic localizations of the CB1 cannabinoid receptor in the dorsal horn of the rat spinal cord

Salio, C., Fischer, J., Franzoni, M. F., & Conrath, M. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00584-x · Cited by 120 · see citing works

The role of prefrontal cortex CB1 receptors in the modulation of fear memory

Lin, H.-C., Mao, S.-C., Su, C.-L., & Gean, P.-W. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn075 · Cited by 119 · see citing works

A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats

Pascual, D., Goicoechea, C., Suardíaz, M., & Martín, M. I. (2005) · Pain · doi:10.1016/j.pain.2005.07.008 · Cited by 117 · see citing works

Cannabinoid Transmission and Pain Perception

Martin, B. R., & Lichtman, A. H. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0218 · Cited by 117 · see citing works

Selective Activation of Cannabinoid CB2 Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats

Rahn, E. J., Zvonok, A. M., Thakur, G. A., Khanolkar, A. D., Makriyannis, A., & Hohmann, A. G. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.141994 · Cited by 116 · see citing works

A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain

Kehl, L. J., Hamamoto, D. T., Wacnik, P. W., Croft, D. L., Norsted, B. D., Wilcox, G. L., & Simone, D. A. (2003) · Pain · doi:10.1016/s0304-3959(02)00450-5 · Cited by 115 · see citing works

Endocannabinoids and related fatty acid derivatives in pain modulation

Walker, J. M., Krey, J. F., Chu, C. J., & Huang, S. M. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00152-4 · Cited by 112 · see citing works

Marijuana and Medicine

Institute of Medicine (1999) · National Academies Press eBooks · doi:10.17226/6376 · Cited by 112 · see citing works

Cannabinoids modulate pain by multiple mechanisms of action

Richardson, J. D. (2000) · The Journal of Pain · doi:10.1016/s1526-5900(00)90082-8 · Cited by 109 · see citing works

Evidence for a role of endogenous cannabinoids in the modulation of acute and tonic pain sensitivity

Strangman, N. M., Patrick, S. L., Hohmann, A. G., Tsou, K., & Walker, J. M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)01031-2 · Cited by 109 · see citing works

Cannabinoid CB1 receptor upregulation in a rat model of chronic neuropathic pain

Siegling, A., Hofmann, H. A., Denzer, D., Mauler, F., & De Vry, J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00798-1 · Cited by 108 · see citing works

Cannabinoids and Pain

Lever, I. J., & Rice, A. S. C. (2007) · Springer eBooks · doi:10.1007/978-3-540-33823-9_10 · Cited by 108 · see citing works

The role of endocannabinoids in pain modulation

Zogopoulos, P., Vasileiou, I., Patsouris, E., & Theocharis, S. E. (2013) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12008 · Cited by 106 · see citing works

Asymmetric synthesis of N-allylic indoles via regio- and enantioselective allylation of aryl hydrazines

Xu, K., Gilles, T., & Breit, B. (2015) · Nature Communications · doi:10.1038/ncomms8616 · Cited by 105 · see citing works

Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve

Costa, B., Trovato, A. E., Colleoni, M., Giagnoni, G., Zarini, E., & Croci, T. (2005) · Pain · doi:10.1016/j.pain.2005.03.043 · Cited by 104 · see citing works

A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation

Nackley, A. G., Suplita, R. L., & Hohmann, A. G. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00870-9 · Cited by 103 · see citing works

Two distinctive antinociceptive systems in rats with pathological pain

Mao, J., Price, D. D., Lü, J., Keniston, L., & Mayer, D. J. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00998-2 · Cited by 104 · see citing works

Regulation of cannabinoid and mu opioid receptors in rat lumbar spinal cord following neonatal capsaicin treatment

Hohmann, A. G., & Herkenham, M. A. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00534-5 · Cited by 102 · see citing works

Role of the endogenous cannabinoid system in the formalin test of persistent pain in the rat

Beaulieu, P., Bisogno, T., Punwar, S., Farquhar-Smith, W. P., Ambrosino, G., Marzo, V. D., & Rice, A. S. C. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00226-0 · Cited by 101 · see citing works

Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells

Burgos, E., Gómez‐Nicola, D., Pascual, D., Martı́n, M. I., Nieto‐Sampedro, M., & Goicoechea, C. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.02.008 · Cited by 99 · see citing works

AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain

Costa, B., Siniscalco, D., Trovato, A. E., Comelli, F., Sotgiu, M. L., Colleoni, M., Maione, S., Rossi, F., & Giagnoni, G. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706798 · Cited by 99 · see citing works

Analgesic, Respiratory and Heart Rate Effects of Cannabinoid and Opioid Agonists in Rhesus Monkeys: Antagonist Effects of SR 141716A

Vivian, J. A., Kishioka, S., Butelman, E. R., Broadbear, J., Lee, K. O., & Woods, J. H. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37642-6 · Cited by 98 · see citing works

Inhibition of pain responses by activation of CB2 cannabinoid receptors

Malan, T. P., Ibrahim, M. M., Vanderah, T. W., Makriyannis, A., & Porreca, F. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00155-x · Cited by 99 · see citing works

Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55

Alba, R. G., Barragán‐Iglesias, P., González‐Hernández, A., Valdez-Moráles, E. E., Granados‐Soto, V., Condés‐Lara, M., Rodríguez, M. G., & Marichal‐Cancino, B. A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01496 · Cited by 94 · see citing works

Interaction of the cannabinoid and opioid systems in the modulation of nociception

Welch, S. P. (2009) · International Review of Psychiatry · doi:10.1080/09540260902782794 · Cited by 92 · see citing works

Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain

Guindon, J., & Beaulieu, P. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.12.002 · Cited by 90 · see citing works

The cannabinoid receptor agonist WIN 55,212-2 mesylate blocks the development of hyperalgesia produced by capsaicin in rats

Li, J., Daughters, R. S., Bullis, C., Bengiamin, R. N., Stucky, M. W., Brennan, J., & Simone, D. A. (1999) · Pain · doi:10.1016/s0304-3959(98)00263-2 · Cited by 90 · see citing works

Actions of N-arachidonyl-glycine in a rat neuropathic pain model

Vuong, L. A. Q., Mitchell, V. A., & Vaughan, C. W. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.004 · Cited by 89 · see citing works

Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain

Costa, B., Colleoni, M., Conti, S., Trovato, A. E., Bianchi, M., Sotgiu, M. L., & Giagnoni, G. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705587 · Cited by 89 · see citing works

The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress

Corcoran, L., Roche, M., & Finn, D. P. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.10.003 · Cited by 86 · see citing works

Neuropathic pain and the endocannabinoid system in the dorsal raphe: pharmacological treatment and interactions with the serotonergic system

Palazzo, E., De Novellis, V., Petrosino, S., Marabese, I., Vita, D., Giordano, C., Di Marzo, V., Mangoni, G. S., Rossi, F., & Maione, S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05086.x · Cited by 86 · see citing works

Possible mechanisms of cannabinoid-induced antinociception in the spinal cord

Morisset, V., Ahluwalia, J. P., Nagy, I., & Urbán, L. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01309-7 · Cited by 86 · see citing works

Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat

Dyson, A., Peacock, M., Chen, A., Courade, J.-P., Yaqoob, M., Groarke, A., Brain, C., Loong, Y., & Fox, A. (2005) · Pain · doi:10.1016/j.pain.2005.03.037 · Cited by 85 · see citing works

Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain

Costa, B., Colleoni, M., Conti, S., Trovato, A. E., Bianchi, M., Sotgiu, M. L., & Giagnoni, G. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705587 · Cited by 89 · see citing works

Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain

Liu, C., & Walker, J. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00498.2006 · Cited by 37 · see citing works

The synthetic cannabinoid WIN55,212‐2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain

Bridges, D., Ahmad, K., & Rice, A. S. C. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704110 · Cited by 221 · see citing works

Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain

Ahmed, M. M., Rajpal, S., Sweeney, C., Gerovac, T. A., Allcock, B., McChesney, S. L., Patel, A. U., Tilghman, J. I., Miranpuri, G. S., & Resnick, D. K. (2010) · The Spine Journal · doi:10.1016/j.spinee.2010.08.015 · Cited by 26 · see citing works

Role of Cannabinoid Receptors in Crocin-Induced Hypoalgesia in Neuropathic Pain in Rats

Vafaei, A. A., Safakhah, H. A., Jafari, S., Tavasoli, A., Rashidy‐Pour, A., Ghanbari, A., Seyedinia, S. A., & Tarahomi, P. (2020) · Journal of Experimental Pharmacology · doi:10.2147/jep.s250738 · Cited by 14 · see citing works