The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Substance P Induction of Itch-Associated Response Mediated by Cutaneous NK1 Tachykinin Receptors in Mice
Abstract
Our experiments were conducted to determine whether substance P (SP) would elicit an itch sensation mediated by mast cells in mice. An intradermal injection of SP (10-135 microgram site-1) into the rostral back of the ICR mouse dose-dependently produced scratching of the injected site. The SP- (135 microgram site-1 = 100 nmol site-1) induced scratching was inhibited by capsaicin (repeated administration) and naloxone; features being similar to itch in humans. SP elicited scratching in mast cell-deficient (WBB6F1 W/Wv) mice as well as control (+/+) mice. Pretreatment with compound 48/80 produced similar degrees of inhibition of SP-induced scratching in mast cell-deficient mice as well as control +/+ and ICR mice. Intradermal injections of the NK1 receptor agonist GR73632 produced dose-dependent scratching, while the NK2 agonist GR64349 and the NK3 agonist senktide were without effects. SP-induced scratching was inhibited by the NK1 receptor antagonists spantide and L-668,169, but not by the NK2 antagonist L-659,877. The results suggest that scratching of the mouse induced by an i.d. injection of SP is itch-associated response. The SP action may be mediated at least partly by cutaneous NK1 receptors, and mast cells may not be key factors in SP-induced itching.
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A controlled trial of naloxone infusions for the pruritus of chronic cholestasis
Bergasa, N. V., Talbot, T. L., Alling, D. W., Schmitt, J. M., Walker, E. C., Baker, B. L., Korenman, J. C., Park, Y., Hoofnagle, J. H., & Jones, E. A. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90102-5 · Cited by 287
Cited by
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 665
Choi, J. E., & Di Nardo, A. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0675-z · Cited by 331
Akiyama, T., & Carstens, E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.035 · Cited by 272
Dual action of neurokinin-1 antagonists on Mas-related GPCRs
Azimi, E., Reddy, V. B., Shade, K.-T. C., Anthony, R. M., Talbot, S., Pereira, P. J. S., & Lerner, E. A. (2016) · JCI Insight · doi:10.1172/jci.insight.89362 · Cited by 178
Ständer, S., Kwon, P., Hirman, J., Perlman, A. J., Weisshaar, E., Metz, M., & Luger, T. A. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2019.01.052 · Cited by 118
Metadata
- Authors
- Andoh, T., Nagasawa, T., Satoh, M., & Kuraishi, Y.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 286
- Issue
- 3
- Pages
- 1140-1145
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W1915108447
- Cited by
- 233
- References
- 1
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Substance P Induction of Itch-Associated Response Mediated by Cutaneous NK1 Tachykinin Receptors in Mice. https://app.cochat.ai/papers/10.1016/s0022-3565(24)37703-1
- The paper
- Andoh, T., Nagasawa, T., Satoh, M., & Kuraishi, Y. (1998). Substance P Induction of Itch-Associated Response Mediated by Cutaneous NK1 Tachykinin Receptors in Mice. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1016/s0022-3565(24)37703-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
