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Cited by 108Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudySubstance Abuse Treatment and Outcomes

The DOI matches its Crossref record; 27 of the 31 references it cites were found in a registry or an index.

Suppression of Nicotine Intake During Ad Libitum Cigarette Smoking by High-Dose Transdermal Nicotine

Benowitz, Neal L., Zevin, Shoshana, Jacob, Peyton·1998·The Journal of Pharmacology and Experimental Therapeutics
DOI 10.1016/s0022-3565(24)37887-5
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Abstract

Nicotine replacement therapy is believed to facilitate smoking cessation both by relieving withdrawal symptoms and by reducing the psychological reward from smoking. The latter might occur via down-regulation of nicotine receptors in the brain, which might require high levels of nicotine exposure. Our study examined the hypothesis that transdermal nicotine, dosed up to three times the doses currently recommended for smoking cessation, would suppress nicotine intake from ad libitum smoking in a dose-dependent manner. Eleven volunteers with no desire to quit smoking received placebo or 21, 42, and 63 mg/day transdermal nicotine, with and without cigarette smoking, in a blinded crossover study. Cigarette smoking was permitted as desired. Transdermal nicotine suppressed nicotine intake from cigarette smoking by 3%, 10% and 40% on average in the 21, 42 and 63 mg/day conditions. The number of cigarettes smoked per day declined from an average of 17.2 to 12.7 and the intake of nicotine per cigarette declined from 2.5 to 1.6 mg, comparing placebo and 63 mg nicotine conditions. Our study results suggest that high-dose transdermal nicotine has the potential to substantially suppress the intake of tobacco smoke and could be a useful strategy for smoking cessation therapy or for reducing the harm caused by smoking.

Overview

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Registry

Crossref · 10.1016/s0022-3565(24)37887-5

Cites

27 of 27 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 1

  1. Benowitz, 1995, Clinical pharmacology of transdermal nicotine., Eur J Pharm Biopharm, 41, 168

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Metadata

Authors
Benowitz, N. L., Zevin, S., & Jacob, P.
Affiliations
San Francisco General Hospital (US)
Venue
The Journal of Pharmacology and Experimental Therapeutics
Publisher
Elsevier BV
Published
1998-12
Volume
287
Issue
3
Pages
958-962
ISSN
0022-3565 (ISSN-L)
DOI
10.1016/s0022-3565(24)37887-5
OpenAlex
W1869016054
Cited by
108
References
31
Citations by year
2024: 1 · 2023: 1 · 2022: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 2 · 2014: 9 · 2013: 3 · 2012: 4
FWCI
2.11
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed
Funders
  • National Institutes of Health (5p50da001696-18, 2m01rr000083-41)
  • National Institute on Drug Abuse (DA02277, DA-01696)
  • National Center for Research Resources (RR 00083)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
transdermal nicotine, nicotine replacement therapy, smoking cessation, tobacco harm reduction
MeSH terms
Administration, Cutaneous, Adult, Carbon Monoxide, Carboxyhemoglobin, Humans, Male, Middle Aged, Nicotine, Smoking, Single-Blind Method, Smoking Cessation, Cross-Over Studies, Nicotinic Agonists

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