Nicotine absorption from electronic cigarette use: comparison between first and new-generation devices
Open accessAbstract
A wide range of electronic cigarette (EC) devices, from small cigarette-like (first-generation) to new-generation high-capacity batteries with electronic circuits that provide high energy to a refillable atomizer, are available for smokers to substitute smoking. Nicotine delivery to the bloodstream is important in determining the addictiveness of ECs, but also their efficacy as smoking substitutes. In this study, plasma nicotine levels were measured in experienced users using a first- vs. new-generation EC device for 1 hour with an 18 mg/ml nicotine-containing liquid. Plasma nicotine levels were higher by 35-72% when using the new- compared to the first-generation device. Compared to smoking one tobacco cigarette, the EC devices and liquid used in this study delivered one-third to one-fourth the amount of nicotine after 5 minutes of use. New-generation EC devices were more efficient in nicotine delivery, but still delivered nicotine much slower compared to tobacco cigarettes. The use of 18 mg/ml nicotine-concentration liquid probably compromises ECs' effectiveness as smoking substitutes; this study supports the need for higher levels of nicotine-containing liquids (approximately 50 mg/ml) in order to deliver nicotine more effectively and approach the nicotine-delivery profile of tobacco cigarettes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nicotine delivery varies across electronic cigarette devices and users.
“While there is evidence of variability in nicotine delivery across devices and users,(311, 312)”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [311]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Suppression of nicotine intake during ad libitum cigarette smoking by high-dose transdermal nicotine
Benowitz, N. L., Zevin, S., & Jacob, P. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37887-5 · Cited by 108 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Soneji, S., Barrington-Trimis, J. L., Wills, T. A., Leventhal, A. M., Unger, J. B., Gibson, L. A., Yang, J., Primack, B. A., Andrews, J. A., Miech, R. A., et al. (2017) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2017.1488 · Cited by 1,170 · see citing works
Primack, B. A., Soneji, S., Stoolmiller, M., Fine, M. J., & Sargent, J. D. (2015) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2015.1742 · Cited by 514 · see citing works
Wagener, T. L., Floyd, E. L., Stepanov, I., Driskill, L. M., Frank, S. G., Meier, E., Leavens, E. L., Tackett, A. P., Molina, N., & Queimado, L. (2017) · Tobacco Control · doi:10.1136/tobaccocontrol-2016-053041 · Cited by 296 · see citing works
Spindle, T. R., Hiler, M. M., Cooke, M. E., Eissenberg, T., Kendler, K. S., & Dick, D. M. (2017) · Addictive Behaviors · doi:10.1016/j.addbeh.2016.12.009 · Cited by 195 · see citing works
England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181 · see citing works
Goniewicz, M. L., Gupta, R., Lee, Y. H., Reinhardt, S., Kim, S., Kim, B., Kosmider, L., & Sobczak, A. (2015) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2015.01.020 · Cited by 146 · see citing works
Cravo, A. S., Bush, J., Sharma, G., Savioz, R., Martin, C., Craige, S., & Walele, T. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.10.003 · Cited by 112 · see citing works
Martinelli, T., Candel, M. J. J. M., de Vries, H., Talhout, R., Knapen, V., van Schayck, C. P., & Nagelhout, G. E. (2023) · Tobacco Control · doi:10.1136/tobaccocontrol-2021-056528 · Cited by 92 · see citing works
Hajek, P., Phillips-Waller, A., Przulj, D., Pesola, F., Smith, K. M., Bisal, N., Li, J., Parrott, S., Sasieni, P., Dawkins, L., et al. (2019) · Health Technology Assessment · doi:10.3310/hta23430 · Cited by 72 · see citing works
Treur, J. L., Rozema, A. D., Mathijssen, J. J. P., van Oers, H., & Vink, J. M. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-017-0345-9 · Cited by 64 · see citing works
Electronic cigarette use and exposure in the pediatric population
Collaco, J. M., Drummond, M. B., & McGrath-Morrow, S. A. (2015) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2014.2898 · Cited by 62 · see citing works
- Authors
- Farsalinos, K. E., Spyrou, A., Tsimopoulou, K., Stefopoulos, C., Romagna, G., & Voudris, V.
- Affiliations
- Onassis Cardiac Surgery Center (GR)
- Corresponding author
- Farsalinos, Konstantinos E.
- Venue
- Scientific Reports
- Published
- 2014-02-26
- Volume
- 4
- Issue
- 1
- Pages
- 4133-4133
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC3935206
- OpenAlex
- W2009119212
- Cited by
- 435
- References
- 1
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 15 · 2023: 17 · 2022: 22 · 2021: 32 · 2020: 32 · 2019: 45 · 2018: 53 · 2017: 65 · 2016: 54 · 2015: 52 · 2014: 30 · 2013: 1
- FWCI
- 44.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- electronic cigarettes, nicotine absorption, plasma nicotine levels, nicotine delivery, smoking cessation, nicotine dependence, atomizer
- MeSH terms
- Adult, Carbon Monoxide, Electronics, Equipment Design, Female, Humans, Male, Motivation, Nicotine, Personal Satisfaction, Tobacco Products, Nicotiana
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
