Relative Potency of levo-α-Acetylmethadol and Methadone in Humans under Acute Dosing Conditions
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Similar hyperbolic dose-response relationships are found for both objective measures (pupillary constriction) and subjective measures (reported drug effect) in humans.
“Similar hyperbolic dose–response relationships are found for both objective measures (pupillary constriction, Figure 4(c)) and subjective measures (reported ‘drug effect’, Figure 4(d)) in humans. 40”
From Tapering and withdrawing opioids: guidance informed by fundamental principles to minimise withdrawal symptoms (2025) · cites this paper as [40]
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Abie Horowitz, M., Framer, A., Strang, J., & Taylor, D. (2025) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253251371504
“…Doi et al. 41 (c) The relationship between oral dose of methadone and reduction in pupil size compared with placebo in humans, derived from data in Eissenberg et al. 40 (d) The relationship between oral dose of methadone and reported drug effect (‘Do you feel any drug effect?’) in humans, derived…”
Influential
- Authors
- Eissenberg, T., Stitzer, M. L., Bigelow, G. E., Buchhalter, A. R., & Walsh, S. L.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1999-05
- Volume
- 289
- Issue
- 2
- Pages
- 936-945
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W4406070367
- Cited by
- 14
- References
- 35
- Citations by year
- 2025: 1 · 2016: 1 · 2013: 1
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
- Keywords
- methadone, relative potency, opioid analgesics, opioid agonists
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