Continuous Infusion of Naloxone in the Treatment of Narcotic Overdose
Abstract
This paper describes case reports and pharmacokinetic information regarding the continuous intravenous administration of naloxone in treatment of narcotic overdose. Continuous naloxone infusion has been used successfully in acutely narcotized patients, and a review of the pharmacodynamic and pharmacokinetic properties of naloxone indicate the reasons for this mode of administration. Summaries of clinical studies in support of the infusion method are given. A naloxone protocol is outlined.
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Opioid antagonists effectively reverse the effects of opiate drugs in humans.
“Opioid antagonists effectively reverse the effects of opiate drugs in humans (Bradberry and Raebel 1981).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Bradberry and Raebel 1981
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- Authors
- Bradberry, J. C., & Raebel, M. A.
- Affiliations
- The University of Texas at Austin (US)
- ORCID
- Raebel, Marsha A.
- Venue
- Drug Intelligence & Clinical Pharmacy
- Publisher
- SAGE Publications
- Published
- 1981-12
- Volume
- 15
- Issue
- 12
- Pages
- 945-950
- ISSN
- 0012-6578 (ISSN-L)
- OpenAlex
- W2111321530
- Cited by
- 68
- References
- 34
- Citations by year
- 2024: 2 · 2023: 3 · 2020: 1 · 2019: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Pharmacotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- naloxone, continuous infusion, opioid overdose, pharmacokinetics, methadone
- MeSH terms
- Adult, Brain, Female, Humans, Infusions, Parenteral, Kinetics, Naloxone, Narcotics
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