delta 9-Tetrahydrocannabinol modulates antigen processing by macrophages.
Abstract
delta 9-Tetrahydrocannabinol (THC) exposure suppresses multiple immunological functions of macrophages. The ability of macrophages exposed to THC to process and present soluble protein antigens was investigated by the stimulation of antigen-specific helper T cell hybridomas to secrete interleukin-2. The T cell response to hen egg lysozyme was dramatically reduced after a 24-hr pretreatment of a macrophage hybridoma with THC. In contrast, THC exposure did not alter the capacity of the macrophage hybridoma to process chicken ovalbumin and augmented their presenting cell function for a pigeon cytochrome c response. These findings could not be attributed to differential effects of THC on either cell viability or expression of the antigen receptor-associated CD3 complex by the T cells. The level of T cell activation with peptides of lysozyme and cytochrome c, which do not require processing, was inhibited only at the highest concentrations of THC, suggesting that THC mainly affects antigen processing. Peritoneal macrophages exposed to THC during an antigen pulse and fixed with paraformaldehyde showed similar effects on the subsequent T cell responses to lysozyme and cytochrome c in the absence of THC, arguing against a possible influence of THC on the T cells. Therefore, THC differentially modulates the capacity of macrophages to process antigens that is necessary for the activation of CD4+ T cells.
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THC indirectly inhibits the activation of T helper cells by suppressing antigen presentation in macrophages.
“Furthermore, THC indirectly inhibits the activation of T helper cells by suppressing antigen presentation in macrophages (McCoy et al, 1995).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as McCoy et al, 1995
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Self-citationHowlett, A. C. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00060-6 · Cited by 536 · see citing works
Carlisle, S. J., Marciano‐Cabral, F., Staab, A., LUDWICK, C., & Cabral, G. A. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00147-3 · Cited by 344 · see citing works
Self-citationDonvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works
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Berdyshev, E. V. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00195-x · Cited by 280 · see citing works
Cannabinoid receptors and endocannabinoids: Evidence for new players
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Rieder, S. A., Chauhan, A., Singh, U., Nagarkatti, M., & Nagarkatti, P. S. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.04.001 · Cited by 264 · see citing works
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BackgroundCannabinoids and the immune system: Potential for the treatment of inflammatory diseases?
Croxford, J. L., & Yamamura, T. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.04.023 · Cited by 256 · see citing works
“1) demonstrated that cannabinoid ligands could suppress phagocytosis, cell spreading, and antigen presentation (Lopez-Cepero et al., 1986; Cabral and Mishkin, 1989; Burnette-Curley et al., 1993; McCoy et al., 1995).”
Zhu, L. X., Sharma, S. P., Stolina, M., Gardner, B. K., Roth, M. D., Tashkin, D. P., & Dubinett, S. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.373 · Cited by 250 · see citing works
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Self-citationCannabinoid receptors and immunity
Klein, T., Newton, C. A., & Friedman, H. P. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)01300-0 · Cited by 235 · see citing works
Cannabinoid signaling in glial cells
Stella, N. (2004) · Glia · doi:10.1002/glia.20084 · Cited by 218 · see citing works
“…an effect that leads to reduced inflammation by, for example, inducing apoptosis of immune cells (McKallip et al., 2002) and inhibiting the ability of macrophages to process antigens and prime helper T cells (McCoy et al., 1995, 1999; Hanus et al., 1999; Buckley et al., 2000; Conti et al., 2002).”
BackgroundMarijuana, immunity and infection
Klein, T., Friedman, H., & Specter, S. C. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00226-9 · Cited by 192 · see citing works
Stefano, G. B., Liu, Y., & Goligorsky, M. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.32.19238 · Cited by 185 · see citing works
Carayon, P., Marchand, J., Dussossoy, D., Derocq, J., Jbilo, O., Bord, A., Bouaboula, M., Galiègue, S., Mondière, P., Pénarier, G., et al. (1998) · Blood · doi:10.1182/blood.v92.10.3605 · Cited by 178 · see citing works
Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells
Klein, T. W., & Cabral, G. A. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-005-9007-x · Cited by 172 · see citing works
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BackgroundInfluentialSelf-citationAlberich-Jordà, M., Verbakel, S. E., Valk, P. J. M., Vankan, Y., Maccarrone, M., Finazzi-Agrò, A., Löwenberg, B., & Delwel, R. (2002) · Blood · doi:10.1182/blood.v99.8.2786 · Cited by 158 · see citing works
Cannabinoids and autoimmune diseases: A systematic review
Katchan, V., David, P., & Shoenfeld, Y. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.02.008 · Cited by 143 · see citing works
“Cannabinoid receptor ligands can suppress spreading and phagocytosis, cytolysis, cytokine production, and antigen presentation in mouse peritoneal macrophages [118-124].”
BackgroundStefano, G. B., Goumon, Y., Bilfinger, T. V., Welters, I. D., & Cadet, P. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00038-6 · Cited by 127 · see citing works
Comparative biology of the endocannabinoid system
Salzet, M., Breton, C., Bisogno, T., & Marzo, V. D. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01550.x · Cited by 118 · see citing works
“(a) by down-regulating macrophage contact-dependent cytolysis of tumor cells [92]; and (b) by altering both antigen processing [93] and the expression of select macrophage-associated proteins [94,95].”
BackgroundXu, H., Cheng, C. L., Chen, M., Manivannan, A., Cabay, L., Pertwee, R. G., Coutts, A. A., & Forrester, J. V. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0307159 · Cited by 116 · see citing works
McCoy, K. L., Matveyeva, M., Carlisle, S. J., & Cabral, G. A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38313-2 · Cited by 115 · see citing works
“The level of secreted IL-2 was the indicator of T cell stimulation and was deficient in cultures containing THC, in agreement with our previous report (McCoy et al., 1995).”
InfluentialSelf-citationKehl, L. J., Hamamoto, D. T., Wacnik, P. W., Croft, D. L., Norsted, B. D., Wilcox, G. L., & Simone, D. A. (2003) · Pain · doi:10.1016/s0304-3959(02)00450-5 · Cited by 115 · see citing works
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BackgroundCabral, G. A., & Staab, A. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-26573-2_13 · Cited by 108 · see citing works
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Massi, P., Vaccani, A., & Parolaro, D. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777947425 · Cited by 98 · see citing works
Stefano, G. B. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00223-3 · Cited by 99 · see citing works
Presence and functional regulation of cannabinoid receptors in immune cells
Parolaro, D. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00286-6 · Cited by 86 · see citing works
Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation
McCoy, K. L. (2016) · Mediators of Inflammation · doi:10.1155/2016/5831315 · Cited by 84 · see citing works
Self-citationStefano, G. B., Salzet, B., & Salzet, M. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01484-9 · Cited by 84 · see citing works
Raborn, E. S., Marciano‐Cabral, F., Buckley, N. E., Martin, B. R., & Cabral, G. A. (2007) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-007-9077-z · Cited by 68 · see citing works
“In addition, THC has been reported to affect macrophage processing of soluble protein antigens (McCoy et al. 1995, 1999).”
BackgroundSelf-citationStefano, G. B., Salzet, M., & Bilfinger, T. V. (1998) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199806000-00009 · Cited by 68 · see citing works
Fichna, J., Bawa, M., Thakur, G. A., Tichkule, R. B., Makriyannis, A., McCafferty, D., Sharkey, K. A., & Storr, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109115 · Cited by 66 · see citing works
The endocannabinoid system in invertebrates
Salzet, M., & Stefano, G. B. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0347 · Cited by 66 · see citing works
Stefano, G. B., Bilfinger, T. V., Rialas, C. M., & Deutsch, D. G. (2000) · Pharmacological Research · doi:10.1006/phrs.2000.0702 · Cited by 64 · see citing works
Greineisen, W. E., & Turner, H. C. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.02.012 · Cited by 63 · see citing works
“In macrophages, again acute suppression of phagocytic effector function is accompanied by a paradoxical elevation in the levels of IL-1 mRNA and hence a likely increase in the secreted levels of this pro-inflammatory cytokine [53, 54].”
BackgroundMastinu, A., Premoli, M., Ferrari‐Toninelli, G., Tambaro, S., Maccarinelli, G., Memo, M., & Bonini, S. A. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0013 · Cited by 60 · see citing works
Hoozen, B. E. V., & Cross, C. E. (1997) · Clinical Reviews in Allergy & Immunology · doi:10.1007/bf02737700 · Cited by 56 · see citing works
Jenny, M., Santer, E., Pirich, E., Schennach, H., & Fuchs, D. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.12.004 · Cited by 55 · see citing works
Autocrine and Paracrine Regulation of Lymphocyte CB2 Receptor Expression by TGF-β
Gardner, B. K., Zu, L. X., Sharma, S. P., Liu, Q., Makriyannis, A., Tashkin, D. P., & Dubinett, S. M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6179 · Cited by 55 · see citing works
Stefano, G. B., Salzet, M., Rialas, C. M., et al. (1998) · International Journal of Cardiology · doi:10.1016/s0167-5273(98)00030-8 · Cited by 51 · see citing works
Rayman, N., Lam, K. H., Laman, J. D., Simons, P. J., Löwenberg, B., Sonneveld, P., & Delwel, R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2111 · Cited by 49 · see citing works
Jenny, M., Schröcksnadel, S., Überall, F., & Fuchs, D. (2010) · Pharmaceuticals · doi:10.3390/ph3082647 · Cited by 69 · see citing works
“On the one hand, both THC and CBD were shown to decrease TNF-α production in human NK cells and peripheral blood mononuclear cells (PBMC), whereas THC was demonstrated to increase TNF-α production in human monocytes [8,9].”
BackgroundInfluentialRole of cannabinoid receptors in inhibiting macrophage costimulatory activity
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Cabral, G. A. (2001) · Journal of Cannabis Therapeutics · doi:10.1300/j175v01n03_06 · Cited by 39 · see citing works
Self-citationKarmaus, P. W. F., Chen, W., Crawford, R. B., Harkema, J. R., Kaplan, B. L. F., & Kaminski, N. E. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0511219 · Cited by 37 · see citing works
Stefano, G. B., Esch, T., Cadet, P., Zhu, W. M., Mantione, K. J., & Benson, H. (2003) · PubMed · Cited by 37 · see citing works
Karoly, H. C., Mueller, R. L., Bidwell, L. C., & Hutchison, K. E. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14256 · Cited by 37 · see citing works
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Toxic Effects of Cannabis and Cannabinoids: Animal Data
Beaulieu, P. (2005) · Pain Research and Management · doi:10.1155/2005/763623 · Cited by 30 · see citing works
“In vitro studies have also demonstrated that cannabinoids alter the functional activities of a variety of immune cell types (28).”
BackgroundLiu, D.-Z., Hu, C.-M., Huang, C.-H., Wey, S., & Jan, T. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.155 · Cited by 28 · see citing works
Rossi, B., Zenaro, E., Angiari, S., Ottoboni, L., Bach, S., Piccio, L. M., Pietronigro, E. C., Scarpini, E. A., Fusco, M., Leon, A., et al. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.12.005 · Cited by 22 · see citing works
“…cell proliferation (Klein et al., 1985; Lee et al., 1995), reduces T and NK cell killing (Klein et al., 1991; Patel et al., 1985), inducesaphenotypeshiftfromTh1toTh2(Yuanetal.,2002)andreduces macrophage-phagocytosis,spreading,cytolysisandantigenpresentation (McCoy et al., 1995; McCoy etal., 1999).”
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Sánchez, C., Velasco, G., & Guzmán, M. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00113-6 · Cited by 21 · see citing works
Cannabinoids lead to enhanced virulence of the smallpox vaccine (vaccinia) virus
Huemer, H. P., Lassnig, C., Bernhard, D., Sturm, S., Nowotny, N. R., Kitchen, M., & Pavlic, M. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.11.001 · Cited by 20 · see citing works
Carayon, P., Marchand, J., Dussossoy, D., et al. (1998) · Blood · doi:10.1182/blood.v92.10.3605.422k05_3605_3615 · Cited by 18 · see citing works
Cannabinoids: an Effective Treatment for Chemotherapy-Induced Peripheral Neurotoxicity?
Cavaletti, G., Marmiroli, P., Renn, C. L., Dorsey, S. G., Serra, M. P., Quartu, M., & Meregalli, C. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01127-1 · Cited by 18 · see citing works
“Furthermore, THC can indirectly inhibit the activation of T helper cells by suppressing antigen presentation in macrophages [40] and it inhibits the proliferation of human T cells stimulated with antigen-primed dendritic cells [41].”
BackgroundSubstance abuse and HIV-gp120: are opiates protective?
Stefano, G. B. (1999) · PubMed · Cited by 16 · see citing works
The Cannabinoid 2 Receptor as a Potential Therapeutic Target for Sepsis
Kasten, K. R., Tschöp, J., Tschöp, M. H., & Caldwell, C. C. (2010) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153010791936874 · Cited by 15 · see citing works
Dendritic Cell Regulation by Cannabinoid-Based Drugs
Svensson, M., Chen, P., & Hammarfjord, O. (2010) · Pharmaceuticals · doi:10.3390/ph3082733 · Cited by 14 · see citing works
Cannabinoid rescue of striatal progenitor cells in chronic Borna Disease viral encephalitis in rats
Solbrig, M. V., & Hermanowicz, N. S. (2008) · Journal of NeuroVirology · doi:10.1080/13550280802074521 · Cited by 14 · see citing works
Cannabinoid Receptor 2 (CB2) in Macrophages: A Promising Clinical Target for Immune Disorders
Yoon, H. H., & Grimsey, N. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178657 · Cited by 10 · see citing works
Matveyeva, M., Hartmann, C. B., Harrison, M. T., et al. (2000) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(99)00092-2 · Cited by 9 · see citing works
Self-citationEndogenous Cannabinoid Ligands
Mechoulam, R., Shabat, S., Hanus, L. O., Fride, E., Bayewitch, M. L., & Vogel, Z. (1996) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0407-4_14 · Cited by 9 · see citing works
Clements, D. J., Matveyeva, M., & McCoy, K. L. (1998) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(98)00044-7 · Cited by 7 · see citing works
Self-citationBreivogel, C. S., McPartland, J. M., & Parekh, B. (2018) · Journal of Receptors and Signal Transduction · doi:10.1080/10799893.2018.1494743 · Cited by 6 · see citing works
Marihuana and the Immune System
Cabral, G. A. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-710-9_32 · Cited by 6 · see citing works
Self-citationStefano, G. B. (2015) · Pharmaceutica Analytica Acta · doi:10.4172/2153-2435.1000378 · Cited by 1 · see citing works
“THC also appears to alter antigen processing [43] and the expression of select proteins whose induction is associated with macrophage activation, as well as the expression of TNF [44,45].”
BackgroundCannabinoid Effects on NFkappaB Function in Microglial-Like Cells: Dual Mode of Action
Griffin-Thomas, L. (2009) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/wzjc-8005 · Cited by 1 · see citing works
The peripheral cannabinoid receptor Cb2 in leukemia
Alberich-Jordà, M. (2004) · RePub (Erasmus University Rotterdam)
Croxford, J. L., & Yamamura, T. (2005)
Lopez, J. G. (2026) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2026.06.013
Cannabinoid Modulation of Chemotaxis of Macrophages and Macrophage-like Cells
Raborn, E. S. (2007) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/qafe-q270
“…also have been shown to modulate the production of cytokine and chemokines by peripheral macrophages as well as microglia, the resident macrophages within the CNS (Klein et al., 2000; McCoy et al., 1995; Puffenbarger et al., 2000; Srivastava et al., 1998; Waksman et al., 1999; Zheng et al., 1992).”
BackgroundMalfait, A. M., Gallily, R., Sumariwalla, P. F., Malik, A. S., Andreakos, E., Mechoulam, R., & Feldmann, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160105897 · Cited by 669 · see citing works
- Authors
- McCoy, K. L., Gainey, D., & Cabral, G. A.
- Affiliations
- Virginia Commonwealth University (US)
- ORCID
- McCoy, K L
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 273
- Issue
- 3
- Pages
- 1216-1223
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2148604002
- Cited by
- 74
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Funders
- National Institutes of Health (5r29ai028422-05)
- National Institute on Drug Abuse (DA05832)
- National Institute of Allergy and Infectious Diseases (AI28422)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- delta-9-tetrahydrocannabinol, macrophages, antigen processing, antigen presentation, T cell activation, interleukin-2, hen egg white lysozyme, chicken ovalbumin, pigeon cytochrome c, CD4+ T cells, immunosuppression, peritoneal macrophages
- MeSH terms
- Animals, Antigen-Presenting Cells, Cell Line, Female, Interleukin-2, Macrophages, Male, Mice, Inbred BALB C, Mice, Inbred CBA, Dronabinol, CD4-Positive T-Lymphocytes, Antigen Presentation, Mice
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