Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells
Abstract
The study of marijuana cannabinoid biology has led to many important discoveries in neuroscience and immunology. These studies have uncovered a new physiological system, the endocannabinoid system, which operates in the regulation of not only brain function but also the regulation of the immune system. Studies examining the effect of cannabinoid-based drugs on immunity have shown that many cellular and cytokine mechanisms are suppressed by these agents leading to the hypothesis that these drugs may be of value in the management of chronic inflammatory diseases. In this report, we review current information on cannabinoid ligand and receptor biology, mechanisms involved in immune suppression by cannabinoids with emphasis on antigen-presenting cells, and preclinical and clinical models analyzing the therapeutic potential of cannabinoid-based drugs.
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Cannabinoids inhibit the cell-specific proliferation of B and T cells.
“Cannabinoids also inhibit the cell-specific proliferation of B and T cells (Cabral and Griffin-Thomas, 2009;Klein and Cabral, 2006).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Klein and Cabral, 2006
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delta 9-Tetrahydrocannabinol modulates antigen processing by macrophages.
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“This suggested that specific proteases, whose function is requisite for processing of specific antigens, were affected by THC (McCoy et al. 1995).”
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Self-citationAnandamide inhibits macrophage-mediated killing of tumor necrosis factor-sensitive cells
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Self-citationCannabinoid-mediated exacerbation of brain infection by opportunistic amebae
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Self-citation9-Tetrahydrocannabinol Suppresses Macrophage Extrinsic Antiherpesvirus Activity
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Self-citationEffect of the cannabinoid ajulemic acid on rat models of neuropathic and inflammatory pain
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Suppression by Cannabinoids of a Cloned Cell Line with Natural Killer Cell Activity
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Resistance to Legionella pneumophila Suppressed by the Marijuana Component, Tetrahydrocannabinol
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Self-citationImmunosuppression by Marijuana and Components
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Self-citationdelta 9-Tetrahydrocannabinol (THC) causes the variable expression of IL2 receptor subunits.
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Self-citationDimethylheptyl-THC-11-oic Acid
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Cannabinoids and the gut: New developments and emerging concepts
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Cannabis Impacts Tumor Response Rate to Nivolumab in Patients with Advanced Malignancies
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Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation
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Drugs of Abuse, Immune Modulation, and AIDS
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Neuroprotective agents: Cannabinoids
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The Cannabinoid Receptor 2 Is Critical for the Host Response to Sepsis
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Modulation of Cannabinoid Receptor Activation as a Neuroprotective Strategy for EAE and Stroke
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Spice/K2 drugs – more than innocent substitutes for marijuana
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The antimicrobial effect behind Cannabis sativa
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Opioid Receptors and Signaling on Cells from the Immune System
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Cannabis smoking and respiratory health: Consideration of the literature
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Immunoregulatory Role of Cannabinoids during Infectious Disease
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Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective
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The endocannabinoid system modulates stress, emotionality, and inflammation
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Self-citationEffects of cannabinoids and their receptors on viral infections
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Cannabis for the treatment of Crohn's disease
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Self-citationToxic effects of prenatal exposure to alcohol, tobacco and other drugs
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Cannabinoids and Viral Infections
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Cannabis for the treatment of Crohn's disease
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Self-citationCannabis for the treatment of ulcerative colitis
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- Authors
- Klein, T. W., & Cabral, G. A.
- Affiliations
- University of South Florida (US)
- Virginia Commonwealth University (US)
- Corresponding author
- Klein, Thomas W.
- ORCID
- Klein, Thomas W.
- Venue
- Journal of Neuroimmune Pharmacology
- Published
- 2006-02-22
- Volume
- 1
- Issue
- 1
- Pages
- 50-64
- ISSN
- 1557-1890 (ISSN-L)
- 1557-1904
- OpenAlex
- W2061663043
- Cited by
- 172
- References
- 139
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 12 · 2020: 16 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 13 · 2015: 6 · 2014: 9 · 2013: 13 · 2012: 6
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmune Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA15608, DA05832, R01DA003646, DA03646, R01DA015608)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- cannabinoids, endocannabinoid system, immunosuppression, antigen-presenting cells, cannabinoid receptors, cytokines, chronic inflammatory diseases, immunomodulation
- MeSH terms
- Animals, Antigen-Presenting Cells, Cannabinoids, Cannabis, Humans, Inflammation, Receptors, Cannabinoid
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