Cited by 172Cannabis and Cannabinoid ResearchImmunotoxicology and immune responsesInflammatory mediators and NSAID effects

Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells

Klein, Thomas W., Cabral, Guy A.·2006·Journal of Neuroimmune Pharmacology

Abstract

The study of marijuana cannabinoid biology has led to many important discoveries in neuroscience and immunology. These studies have uncovered a new physiological system, the endocannabinoid system, which operates in the regulation of not only brain function but also the regulation of the immune system. Studies examining the effect of cannabinoid-based drugs on immunity have shown that many cellular and cytokine mechanisms are suppressed by these agents leading to the hypothesis that these drugs may be of value in the management of chronic inflammatory diseases. In this report, we review current information on cannabinoid ligand and receptor biology, mechanisms involved in immune suppression by cannabinoids with emphasis on antigen-presenting cells, and preclinical and clinical models analyzing the therapeutic potential of cannabinoid-based drugs.

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Crossref · 10.1007/s11481-005-9007-x

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140 of 140 references verified0 citation errors · 0 not checkable

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Authors
Klein, T. W., & Cabral, G. A.
Affiliations
  • University of South Florida (US)
  • Virginia Commonwealth University (US)
Corresponding author
Klein, Thomas W.
Venue
Journal of Neuroimmune Pharmacology
Published
2006-02-22
Volume
1
Issue
1
Pages
50-64
ISSN
  • 1557-1890 (ISSN-L)
  • 1557-1904
OpenAlex
W2061663043
Cited by
172
References
139
Citations by year
2026: 4 · 2025: 6 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 12 · 2020: 16 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 13 · 2015: 6 · 2014: 9 · 2013: 13 · 2012: 6
FWCI
0.94
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroimmune Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (DA15608, DA05832, R01DA003646, DA03646, R01DA015608)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
cannabinoids, endocannabinoid system, immunosuppression, antigen-presenting cells, cannabinoid receptors, cytokines, chronic inflammatory diseases, immunomodulation
MeSH terms
Animals, Antigen-Presenting Cells, Cannabinoids, Cannabis, Humans, Inflammation, Receptors, Cannabinoid

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