Increased running response to morphine in morphine-pretreated mice.
Abstract
The running response of B6AF1/J mice to 25 mg/kg of morphine sulfate was increased up to 3-fold when this dose was administered either twice daily for 5 days or once a week for 2 or 3 weeks. The effect of weekly pretreatment was proportional to the dose of morphine and lasted as long as 1 month after pretreatment was stopped. There was no sensitization when the mice were less than 15 days old at the time of pretreatment. Of the parental strains, untreated C57Bl/6J mice showed a good running response to morphine, while A/J mice showed little response. Pretreatment of either of these strains produced only slight sensitization. Pretreatment of the hybrids with levorphanol increased the response to morphine. Dextrorphan and naloxone were ineffective. Sensitization by morphine was blocked by naloxone. Increased morphine running was not associated with analgesic tolerance as measured by the tail-flick assay. Morphine pretreatment produced some increase in the running response to amphetamine and to cocaine. Pretreatment with amphetamine or cocaine did not increase the response to morphine.
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Mice demonstrate behavioral or psychomotor sensitization up to 8 months after morphine exposure.
“and up to 8 months after morphine exposure (Shuster, Webster, & Yu, 1975)”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Shuster, Webster, & Yu, 1975
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- Authors
- Shuster, L., Webster, G. W., & Yu, G.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1975-01
- Volume
- 192
- Issue
- 1
- Pages
- 64-72
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W1924136303
- Cited by
- 68
- References
- 0
- Citations by year
- 2026: 1 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- PubMed
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- morphine, morphine sensitization, naloxone, analgesic tolerance, strain differences, C57BL/6J mice, A/J mice, levorphanol, amphetamine, cocaine, locomotor activity
- MeSH terms
- Aging, Analgesics, Opioid, Animals, Animals, Newborn, Cocaine, Dextroamphetamine, Dose-Response Relationship, Drug, Drug Tolerance, Female, Hot Temperature, Levorphanol, Male, Mice, Inbred A, Mice, Inbred C57BL, Morphine, Motor Activity, Naloxone, Reaction Time, Species Specificity, Stereoisomerism, Stimulation, Chemical, Time Factors, Mice
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