NMDA receptor hypofunction model of schizophrenia

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Reduced Levels of Serotonin 2A Receptors Underlie Resistance of Egr3-Deficient Mice to Locomotor Suppression by Clozapine

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Gestational Methylazoxymethanol Exposure Leads to NMDAR Dysfunction in Hippocampus During Early Development and Lasting Deficits in Learning

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Cannabinoids and Vanilloids in Schizophrenia: Neurophysiological Evidence and Directions for Basic Research

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The Homer1 family of proteins at the crossroad of dopamine-glutamate signaling: An emerging molecular “Lego” in the pathophysiology of psychiatric disorders. A systematic review and translational insight

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Pharmacological disruption of mouse social approach behavior: Relevance to negative symptoms of schizophrenia

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Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus

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Development of the MAM model of schizophrenia in mice: Sex similarities and differences of hippocampal and prefrontal cortical function

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Antidepressant-like effects of ketamine in a mouse model of serotonergic dysfunction

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Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling

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Nicotine and smoker status moderate brain electric and mood activation induced by ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist

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d ‐amino acid oxidase knockout ( Dao −/− ) mice show enhanced short‐term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption

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Synthesis, SAR and Unanticipated Pharmacological Profiles of Analogues of the mGluR5 Ago‐potentiator ADX‐47273

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Glycine transport inhibitors as potential antipsychotic drugs

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Microinfusion of the non-competitive N-methyl-d-aspartate receptor antagonist MK-801 (dizocilpine) into the dorsal hippocampus of Wistar rats does not affect latent inhibition and prepulse inhibition, but increases startle reaction and locomotor activity

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Atypical Antipsychotics and a Src Kinase Inhibitor (PP1) Prevent Cortical Injury Produced by the Psychomimetic, Noncompetitive NMDA Receptor Antagonist MK-801

Dickerson, J., & Sharp, F. R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300878 · Cited by 35

A low dose of the alpha2 agonist clonidine ameliorates the visual attention and spatial working memory deficits produced by phencyclidine administration to rats

Jentsch, J. D., & Anzivino, L. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1772-3 · Cited by 35

Early postnatal depletion of NMDA receptor development affects behaviour and NMDA receptor expression until later adulthood in rats—A possible model for schizophrenia

Baier, P. C., Blume, A., Koch, J. M., Marx, A., Fritzer, G., Aldenhoff, J. B., & Schiffelholz, T. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.018 · Cited by 33

The synthesis and preclinical evaluation in rhesus monkey of [18F]MK‐6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers

Hamill, T. G., Eng, W., Jennings, A. S. R., Lewis, R. T., Thomas, S., Wood, S., Street, L. J., Wisnoski, D. D., Wolkenberg, S. E., Lindsley, C. W., et al. (2010) · Synapse · doi:10.1002/syn.20842 · Cited by 34

Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: exemplified by activity of an mGlu2/3 receptor agonist

Dedeurwaerdere, S., Wintmolders, C., Straetemans, R., Pemberton, D. J., & Langlois, X. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2052-z · Cited by 34

Mitochondrial impairment, apoptosis and autophagy in a rat brain as immediate and long-term effects of perinatal phencyclidine treatment — influence of restraint stress

Jevtić, G., Nikolić, T., Mirčić, A., Stojković, T., Velimirović, M., Trajković, V., Marković, I., Trbovich, A. M., Radonjić, N. V., & Petronijević, N. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.11.014 · Cited by 34

Acute and long‐term effects of MK‐801 on direct cortical input evoked homosynaptic and heterosynaptic plasticity in the CA1 region of the female rat

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Annual Research Review: Transgenic mouse models of childhood‐onset psychiatric disorders

Robertson, H. R., & Feng, G. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02380.x · Cited by 33

The interactive effects of ketamine and nicotine on human cerebral blood flow

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Searching for cognitive enhancement in the Morris water maze: better and worse performance in D‐amino acid oxidase knockout (Dao−/−) mice

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Treatment with levetiracetam improves cognition in a ketamine rat model of schizophrenia

Koh, M. T., Shao, Y., Rosenzweig-Lipson, S. J., & Gallagher, M. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.06.027 · Cited by 33

Nicotine ameliorates NMDA receptor antagonist-induced deficits in contextual fear conditioning through high-affinity nicotinic acetylcholine receptors in the hippocampus

André, J. M., Leach, P. T., & Gould, T. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.004 · Cited by 32

Glutamate NMDA Receptor Antagonists with Relevance to Schizophrenia: A Review of Zebrafish Behavioral Studies

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PD168077, a D 4 receptor agonist, reverses object recognition deficits in rats: potential role for D 4 receptor mechanisms in improving cognitive dysfunction in schizophrenia

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Has psychiatry tamed the “ketamine tiger?” Considerations on its use for depression and anxiety

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Beyond Dopamine: Glutamate as a Target for Future Antipsychotics

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The p250GAP Gene Is Associated with Risk for Schizophrenia and Schizotypal Personality Traits

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Supplementation of antipsychotic treatment with sarcosine – GlyT1 inhibitor – causes changes of glutamatergic 1NMR spectroscopy parameters in the left hippocampus in patients with stable schizophrenia

Strzelecki, D., Podgórski, M. T., Kałużyńska, O., Gawlik-Kotelnicka, O., Stefańczyk, L., Kotlicka‐Antczak, M., Gmitrowicz, A., & Grzelak, P. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.08.039 · Cited by 32

Cognitive and Emotional Abnormalities in Systemic Lupus Erythematosus: Evidence for Amygdala Dysfunction

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In utero PCP exposure alters oligodendrocyte differentiation and myelination in developing rat frontal cortex

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Involvement of glutamatergic and GABAergic transmission in MK-801-increased gamma band oscillation power in rat cortical electroencephalograms

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The Discovery and Characterization of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N -{(3 S ,4 S )-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)

Shaffer, C. L., Patel, N. C., Schwarz, J. B., Scialis, R. J., Wei, Y., Hou, X., Xie, L., Karki, K., Bryce, D. K., Osgood, S. M., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00300 · Cited by 33

The neuropathogenesis of mercury toxicity

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Alterations of plasma and cerebrospinal fluid glutamate levels in rats treated with the N-methyl-D-aspartate receptor antagonist, ketamine.

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Glutamatergic hypothesis of schizophrenia: involvement of Na+/K+-dependent glutamate transport

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Neuropharmacological Profile of a Novel Potential Atypical Antipsychotic Drug Y-931 (8-fluoro-12-(4-methylpiperazin-1-yl)- 6H-[1]benzothieno[2,3-b][1,5] benzodiazepine maleate)

Morimoto, T. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00368-2 · Cited by 32

NMDA Receptors Control Cue-Outcome Selectivity and Plasticity of Orbitofrontal Firing Patterns during Associative Stimulus-Reward Learning

van Wingerden, M., Vinck, M. A., Tijms, V., Ferreira, I. R. S., Jonker, A. J., & Pennartz, C. M. A. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.039 · Cited by 32

Pharmacological Manipulation of Cortical Inhibition in the Dorsolateral Prefrontal Cortex

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NMDA receptor channel gating control by the pre-M1 helix

McDaniel, M. J., Ogden, K. K., Kell, S. A., Burger, P. B., Liotta, D. C., & Traynelis, S. F. (2020) · The Journal of General Physiology · doi:10.1085/jgp.201912362 · Cited by 29

Supplementation of Antipsychotic Treatment with the Amino Acid Sarcosine Influences Proton Magnetic Resonance Spectroscopy Parameters in Left Frontal White Matter in Patients with Schizophrenia

Strzelecki, D., Podgórski, M. T., Kałużyńska, O., Gawlik-Kotelnicka, O., Stefańczyk, L., Kotlicka‐Antczak, M., Gmitrowicz, A., & Grzelak, P. (2015) · Nutrients · doi:10.3390/nu7105427 · Cited by 32

Complexin2 null mutation requires a ‘second hit’ for induction of phenotypic changes relevant to schizophrenia

Radyushkin, K., El-Kordi, A., Boretius, S., Vega, S. C., Ronnenberg, A., Reim, K., Bickeböller, H., Frahm, J., Brose, N., & Ehrenreich, H. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00590.x · Cited by 31

Antipsychotic compounds differentially modulate high-frequency oscillations in the rat nucleus accumbens: a comparison of first- and second-generation drugs

Olszewski, M., Piasecka, J., Goda, S. A., Kasicki, S., & Hunt, M. J. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001034 · Cited by 31

From Toxoplasmosis to Schizophrenia via NMDA Dysfunction: Peptide Overlap between Toxoplasma gondii and N-Methyl-d-Aspartate Receptors As a Potential Mechanistic Link

Lucchese, G. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00037 · Cited by 34

Acute and Chronic Effects of Ketamine on Semantic Priming

Stefanovic, A., Brandner, B., Klaassen, E. B., Cregg, R., Nagaratnam, M., Bromley, L. M., Das, R., Rossell, S. L., Morgan, C. J. A., & Curran, H. V. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31819a4b91 · Cited by 31

N-acetylaspartate reductions in the mediodorsal and anterior thalamus in men with schizophrenia verified by tissue volume corrected proton MRSI

Jakary, A., Vinogradov, S., Feiwell, R., & Deicken, R. F. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.02.012 · Cited by 31

Genetic Evidence for the Association between the Early Growth Response 3 (EGR3) Gene and Schizophrenia

Zhang, R., Lu, S., Meng, L., Min, Z., Tian, J., Valenzuela, R. K., Guo, T., Tian, L., Zhao, W., & Ma, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030237 · Cited by 30

ON or OFF?: Modulating the N-Methyl-D-Aspartate Receptor in Major Depression

Chan, S. Y., Matthews, E., & Burnet, P. W. J. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00169 · Cited by 32

Resting‐state glutamatergic neurotransmission is related to the peak latency of the auditory mismatch negativity (MMN) for duration deviants: An 1 H‐MRS‐EEG study

Kompus, K., Westerhausen, R., Craven, A. R., Kreegipuu, K., Põldver, N., Passow, S., Specht, K., Hugdahl, K., & Näätänen, R. (2015) · Psychophysiology · doi:10.1111/psyp.12445 · Cited by 30

Subunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction

Pittman-Polletta, B., Hu, K., & Kocsis, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-29331-8 · Cited by 29

An investigation of retinal layer thicknesses in unaffected first-degree relatives of schizophrenia patients

Kurtulmuş, A., Elbay, A., Yıldız, F. B. P., Kılıçarslan, T., Ozdemir, M. H., & Kırpınar, İ. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2019.12.034 · Cited by 30

Early-onset schizophrenia is associated with impaired adolescent development of attentional capacity using the identical pairs continuous performance test

Thaden, E. P., Rhinewine, J. P., Lencz, T., Kester, H. M., Cervellione, K. L., Henderson, I., Roofeh, D., Burdick, K. E., Napolitano, B. A., Cornblatt, B. A., et al. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.09.015 · Cited by 30

NMDAR hypofunction and somatostatin-expressing GABAergic interneurons and receptors: A newly identified correlation and its effects in schizophrenia

Alherz, F. A., Alherz, M., & Almusawi, H. M. (2017) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2017.02.001 · Cited by 32

Functional magnetic resonance spectroscopy in patients with schizophrenia and bipolar affective disorder: Glutamate dynamics in the anterior cingulate cortex during a working memory task

Jelen, L. A., King, S., Horne, C. M., Lythgoe, D. J., Young, A. H., & Stone, J. M. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.12.005 · Cited by 29

DNA damage and repair in neuropsychiatric disorders. What do we know and what are the future perspectives?

Czarny, P. L., Białek, K. I., Ziółkowska, S., Strycharz, J., & Śliwiński, T. (2019) · Mutagenesis · doi:10.1093/mutage/gez035 · Cited by 32

Multiple ‘hits’ during postnatal and early adulthood periods disrupt the normal development of sensorimotor gating ability in rats

Chen, J., Wang, Z.-C., & Li, M. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881109354929 · Cited by 25

Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease

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The putative functional rs1045881 marker of neurexin-1 in schizophrenia and clozapine response

Lett, T. A. P., Tiwari, A. K., Meltzer, H. Y., Lieberman, J. A., Potkin, S. G., Voineskos, A. N., Kennedy, J. L., & Müller, D. J. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.08.007 · Cited by 28

Low plasma concentrations of N-methyl-d-aspartate receptor subunits as a possible biomarker for psychosis

Loureiro, C. M., Shuhama, R., Fachim, H., Menezes, P. R., Del‐Ben, C. M., & Louzada‐Júnior, P. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.06.037 · Cited by 28

Parvalbumin Interneurons and Perineuronal Nets in the Hippocampus and Retrosplenial Cortex of Adult Male Mice After Early Social Isolation Stress and Perinatal NMDA Receptor Antagonist Treatment

Klimczak, P., Rizzo, A., Castillo-Gómez, E., Pérez-Rando, M., Gramuntell, Y., Beltrán, M. A. C. S., & Nácher, J. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.733989 · Cited by 31

Modulation of NMDA receptor function as a treatment for schizophrenia

Cioffi, C. L. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.07.019 · Cited by 28

Behavioral effects of orally administered glycine in socially housed monkeys chronically treated with phencyclidine

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Perinatal MK-801 treatment affects age-related changes in locomotor activity from childhood to later adulthood in rats

Schiffelholz, T., Hinze‐Selch, D., & Aldenhoff, J. B. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.02.064 · Cited by 28

Inhibition of cerebral type 1 cannabinoid receptors is associated with impaired auditory mismatch negativity generation in the ketamine model of schizophrenia

Roser, P., Haussleiter, I. S., Chong, H.-J., Maier, C., Kawohl, W., Norra, C., & Juckel, G. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2352-y · Cited by 28

Perceptual organization in schizophrenia: Plasticity and state-related change

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Astrocytes as Pharmacological Targets in the Treatment of Schizophrenia

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Enhancement of long-term potentiation at CA1-subiculum synapses in MK-801-treated rats

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