Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444 · see citing works

Cell Death: The Significance of Apoptosis

Wyllie, A. H., Kerr, J. F. R., & Currie, A. R. (1980) · International review of cytology · doi:10.1016/s0074-7696(08)62312-8 · Cited by 7,235 · see citing works

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 2,989 · see citing works

RECOGNITION OF THE FETAL ALCOHOL SYNDROME IN EARLY INFANCY

Jones, K., & Smith, D. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91092-1 · Cited by 2,780 · see citing works

Comparative aspects of the brain growth spurt

Dobbing, J., & Sands, J. (1979) · Early Human Development · doi:10.1016/0378-3782(79)90022-7 · Cited by 2,506 · see citing works

Ketamine—its pharmacology and therapeutic uses

white, P. F., Way, W. L., & Trevor, A. J. (1982) · Anesthesiology · doi:10.1097/00000542-198202000-00007 · Cited by 1,474 · see citing works

Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons

Lovinger, D. M., White, G., & Weight, F. F. (1989) · Science · doi:10.1126/science.2467382 · Cited by 1,447 · see citing works

In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

Kraupp, B. G., Ruttkay-Nedecký, B., Koudelka, H., Bukowska, K., Bursch, W., & Schulte‐Hermann, R. (1995) · Hepatology · doi:10.1002/hep.1840210534 · Cited by 1,167 · see citing works

Modulation of Neuronal Migration by NMDA Receptors

Komuro, H., & RAKIC, P. T. (1993) · Science · doi:10.1126/science.8096653 · Cited by 1,041 · see citing works

GABAA, NMDA and AMPA receptors: a developmentally regulated 'ménage à trois'

Ben‐Ari, Y. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01147-8 · Cited by 795 · see citing works

Ketamine: an update on the first twenty-five years of clinical experience

Reich, D. L., & Silvay, G. (1989) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03011442 · Cited by 707 · see citing works

Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin

Jevtović‐Todorović, V., Todorovć, S. M., Mennerick, S. J., Powell, S., Dikranian, K. T., Benshoff, N. D., Zorumski, C. F., & Olney, J. W. (1998) · Nature Medicine · doi:10.1038/nm0498-460 · Cited by 675 · see citing works

N‐Methyl‐D‐Aspartate Receptors and Ethanol: Inhibition of Calcium Flux and Cyclic GMP Production

Hoffman, P. L., Rabe, C. S., Moses, F. E., & Tabakoff, B. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07280.x · Cited by 566 · see citing works

In situ detection of fragmented DNA (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note*1

Grasl‐Kraupp, B. (1995) · Hepatology · doi:10.1016/0270-9139(95)90071-3 · Cited by 517 · see citing works

A cautionary note on the use of the TUNEL stain to determine apoptosis

Charriaut‐Marlangue, C., & Ben‐Ari, Y. (1995) · Neuroreport · doi:10.1097/00001756-199512000-00014 · Cited by 509 · see citing works

Differential expression of five N‐methyl‐D‐aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats

Akazawa, C., Shigemoto, R., Bessho, Y., Nakanishi, S., & Mizuno, N. (1994) · The Journal of comparative neurology · doi:10.1002/cne.903470112 · Cited by 490 · see citing works

Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity

Ikonomidou, C., Mosinger, J., Salles, K., Labruyere, J., & Olney, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-08-02809.1989 · Cited by 332 · see citing works

Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro.

Guerrini, L., Blasi, F., & Denis‐Donini, S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9077 · Cited by 287 · see citing works

Expression of mRNAs Encoding Subunits of the NMDA Receptor in Developing Rat Brain

Zhong, J., Carrozza, D. P., Williams, K. L., Pritchett, D. B., & Molinoff, P. B. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020531.x · Cited by 251 · see citing works

Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus

Gould, E., Cameron, H. A., & McEwen, B. S. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903400408 · Cited by 244 · see citing works

Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons

Yan, G.-M., Ni, B., Weller, M., Wood, K. A., & Paul, S. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91364-1 · Cited by 171 · see citing works

An improved cupric-silver method for impregnation of axonal and terminal degeneration

de Olmos, J. S., & Ingram, W. R. (1971) · Brain Research · doi:10.1016/0006-8993(71)90130-2 · Cited by 170 · see citing works

Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats.

Vezzani, A., Serafini, R., Stasi, M. A., Caccia, S., Conti, I., Tridico, R. V., & SAMANIN, R. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23251-7 · Cited by 165 · see citing works

Alterations in Gait Following Ethanol Exposure During the Brain Growth Spurt in Rats

Meyer, L. S., Kotch, L. E., & Riley, E. P. (1990) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1990.tb00440.x · Cited by 96 · see citing works

Prenatal Alcohol Exposure and Infant Behavior:

Coles, C. D., Smith, I. E., & Falek, A. (1987) · Advances in Alcohol & Substance Abuse · doi:10.1300/j251v06n04_07 · Cited by 59 · see citing works

Effects of halothane anesthesia on the biodisposition of ketamine in rats.

White, P. F., Marietta, M. P., PUDWILL, C. R., Way, W. L., & Trevor, A. J. (1976) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30448-9 · Cited by 56 · see citing works

Density and distribution of excitatory amino acid receptors in the developing human fetal brain: A quantitative autoradiographic study

Lee, H., & Choi, B. H. (1992) · Experimental Neurology · doi:10.1016/0014-4886(92)90185-s · Cited by 54 · see citing works

Ethanol neurobehavioural teratogenesis and the role of L -glutamate in the fetal hippocampus

Reynolds, J. D. H., & Brien, J. F. (1995) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y95-173 · Cited by 51 · see citing works

Interactive effects involving different classes of excitatory amino acid receptors and the survival of cerebellar granule cells in culture

Balázs, R., Hack, N., & Jørgensen, O. S. (1990) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(90)90068-d · Cited by 48 · see citing works

Anti-phencyclidine monoclonal Fab fragments markedly alter phencyclidine pharmacokinetics in rats.

Valentine, J. L., Arnold, L. W., & Owens, S. M. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38842-7 · Cited by 43 · see citing works

CSF and plasma pharmacokinetics of the NMDA receptor antagonist CPP after intrathecal, extradural and i.v. administration in anaesthetized pigs

Kristensen, J. D., HARTVIG, P., Karlsten, R., Gordh, T., & Halldin, M. M. (1995) · British Journal of Anaesthesia · doi:10.1093/bja/74.2.193 · Cited by 30 · see citing works

Amelioration by the Ca2+antagonist, nimodipine of an existing neuropathy in the streptozotocin‐induced, diabetic rat

Kappelle, A. C., Bravenboer, B., van Buren, T., Traber, J., Erkelens, D. W., & Gispen, W. H. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb12878.x · Cited by 28 · see citing works

Nimodipine and the recovery of memory

Izquierdo, I. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90229-2 · Cited by 27 · see citing works

Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits

Jevtovic-Todorovic, V., Hartman, R. E., Izumi, Y., Benshoff, N. D., Dikranian, K., Zorumski, C. F., Olney, J. W., & Wozniak, D. F. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00876.2003 · Cited by 1,983 · see citing works

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686 · see citing works

Glutamate as a neurotransmitter in the brain: review of physiology and pathology

Meldrum, B. S. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.4.1007s · Cited by 1,667 · see citing works

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644 · see citing works

Ethanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome

Ikonomidou, C., Bittigau, P., Ishimaru, M. J., Wozniak, D. F., Koch, C. A., Genz, K., Price, M. T., Stefovska, V. G., Hörster, F., Tenkova, T., et al. (2000) · Science · doi:10.1126/science.287.5455.1056 · Cited by 1,357 · see citing works

Early Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort

Wilder, R. T., Flick, R. P., Šprung, J., Katusic, S. K., Barbaresi, W. J., Mickelson, C., Gleich, S. J., Schroeder, D. R., Weaver, A. L., & Warner, D. O. (2009) · Anesthesiology · doi:10.1097/01.anes.0000344728.34332.5d · Cited by 1,358 · see citing works

Mitochondria and neuronal survival

Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243 · see citing works

Neonatal Brain Injury

Ferriero, D. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra041996 · Cited by 1,148 · see citing works

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

Lai, T. W., Zhang, S., & Wang, Y. T. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.006 · Cited by 1,106 · see citing works

The changing landscape of ischaemic brain injury mechanisms

Lee, J.-M., Zipfel, G. J., & Choi, D. W. (1999) · Nature · doi:10.1038/399a007 · Cited by 1,102 · see citing works

NMDA receptor hypofunction model of schizophrenia

Olney, J. W., Newcomer, J. W., & Farber, N. B. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00029-1 · Cited by 1,020 · see citing works

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

Wang, R., & Reddy, P. H. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160763 · Cited by 1,009 · see citing works

Cognitive and Behavioral Outcomes After Early Exposure to Anesthesia and Surgery

Flick, R. P., Katusic, S. K., Colligan, R. C., Wilder, R. T., Voigt, R. G., Olson, M. D., Šprung, J., Weaver, A. L., Schroeder, D. R., & Warner, D. O. (2011) · PEDIATRICS · doi:10.1542/peds.2011-0351 · Cited by 904 · see citing works

Antiepileptic drugs and apoptotic neurodegeneration in the developing brain

Bittigau, P., Sifringer, M., Genz, K., Reith, E., Pospischil, D., Govindarajalu, S., Dzietko, M., Pesditschek, S., Mai, I., Dikranian, K. T., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222550499 · Cited by 777 · see citing works

NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both <i>In Vitro</i> and <i>In Vivo</i>

Liu, Y., Wong, T. P., Aarts, M., Rooyakkers, A., Liu, L., Lai, T. W., Wu, D. C., Lu, J., Tymianski, M., Craig, A. M., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0116-07.2007 · Cited by 773 · see citing works

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Tuo, Q., Zhang, S., & Lei, P. (2021) · Medicinal Research Reviews · doi:10.1002/med.21817 · Cited by 747 · see citing works

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

Ikonomidou, C., & Turski, L. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00164-3 · Cited by 727 · see citing works

Schizophrenia as a Disorder of Developmentally Reduced Synaptic Connectivity

McGlashan, T. H. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.7.637 · Cited by 655 · see citing works

The Yin and Yang of NMDA receptor signalling

Hardingham, G. E., & Bading, H. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)00040-1 · Cited by 619 · see citing works

Can Adverse Neonatal Experiences Alter Brain Development and Subsequent Behavior?

Anand, K. J. S., & Scalzo, F. M. (2000) · Neonatology · doi:10.1159/000014197 · Cited by 615 · see citing works

Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey

Slikker, W., Zou, X., Hotchkiss, C. E., Divine, R. L., Sadovova, N., Twaddle, N. C., Doerge, D. R., Scallet, A. C., Patterson, T. A., Hanig, J. P., et al. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm084 · Cited by 606 · see citing works

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

Savelieff, M. G., Nam, G., Kang, J., Lee, H. J., Lee, M., & Lim, M. H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00138 · Cited by 603 · see citing works

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide‐induced apoptosis: significance for the molecular mechanism of Bcl‐2 action

Pinton, P., Ferrari, D., Rapizzi, E., Virgilio, F. D., Pozzan, T., & Rizzuto, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2690 · Cited by 599 · see citing works

Ketamine and other NMDA antagonists: early clinical trials and possible mechanisms in depression.

Newport, D. J., Carpenter, L. L., McDonald, W. M., Potash, J. B., Tohen, M., Nemeroff, C. B., & The APA Council of Research Task Force on Novel Biomarkers and Treatments (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15040465 · Cited by 598 · see citing works

Isoflurane-induced Neuroapoptosis in the Neonatal Rhesus Macaque Brain

Brambrink, A. M., Evers, A. S., Avidan, M. S., Farber, N. B., Smith, D. J., Zhang, X., Dissen, G. A., Creeley, C. E., & Olney, J. W. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181d049cd · Cited by 587 · see citing works

Glutamatergic mechanisms in schizophrenia

Tsai, G., & Coyle, J. T. (2002) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.082701.160735 · Cited by 577 · see citing works

Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys

Paule, M. G., Li, M., Allen, R. R., Liu, F., Zou, X., Hotchkiss, C. E., Hanig, J. P., Patterson, T. A., Slikker, W., & Wang, C. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.01.001 · Cited by 570 · see citing works

HYPOXIC-ISCHEMIC ENCEPHALOPATHY

Vannucci, R. C. (2000) · American Journal of Perinatology · doi:10.1055/s-2000-9293 · Cited by 525 · see citing works

GABAergic interneuron origin of schizophrenia pathophysiology

Nakazawa, K., Zsiros, V., Jiang, Z., Nakao, K., Kolata, S., Zhang, S., & Belforte, J. E. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.022 · Cited by 498 · see citing works

The Ca2+–calmodulin-dependent protein kinase cascade

Soderling, T. R. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01383-3 · Cited by 509 · see citing works

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Papadia, S., Soriano, F. X., Léveillé, F., Martel, M.-A., Dakin, K. A., Hansen, H. H., Kaindl, A., Sifringer, M., Fowler, J., Stefovska, V., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2071 · Cited by 498 · see citing works

Lasting impact of general anaesthesia on the brain: mechanisms and relevance

Vutskits, L., & Xie, Z. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.128 · Cited by 487 · see citing works

Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain

Young, C., Jevtović‐Todorović, V., Qin, Y.-Q., Tenkova, T. I., Wang, H., Labruyere, J., & Olney, J. W. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706301 · Cited by 470 · see citing works

Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain

Creeley, C. E., Dikranian, K. T., Dissen, G. A., Martin, L., Olney, J. W., & Brambrink, A. M. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet173 · Cited by 466 · see citing works

Autoimmune encephalomyelitis ameliorated by AMPA antagonists

Smith, T., Groom, A., Zhu, B., & Turski, L. (2000) · Nature Medicine · doi:10.1038/71548 · Cited by 467 · see citing works

Apoptosis and the Nervous System

Sastry, P. S., & Rao, K. S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740001.x · Cited by 458 · see citing works

Astaxanthin: A mechanistic review on its biological activities and health benefits

Fakhri, S., Abbaszadeh, F., Dargahi, L., & Jorjani, M. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.08.012 · Cited by 465 · see citing works

An Assessment of the Effects of General Anesthetics on Developing Brain Structure and Neurocognitive Function

Loepke, A. W., & Soriano, S. G. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318167ad77 · Cited by 452 · see citing works

Role of Glycogen Synthase Kinase-3β in Neuronal Apoptosis Induced by Trophic Withdrawal

Hetman, M., Cavanaugh, J. E., Kimelman, D., & Xia, Z. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02567.2000 · Cited by 440 · see citing works

Ketamine-induced Neuroapoptosis in the Fetal and Neonatal Rhesus Macaque Brain

Brambrink, A. M., Evers, A. S., Avidan, M. S., Farber, N. B., Smith, D. J., Martin, L. D., Dissen, G. A., Creeley, C. E., & Olney, J. W. (2012) · Anesthesiology · doi:10.1097/aln.0b013e318242b2cd · Cited by 427 · see citing works

Neonatal Exposure to a Combination of N -Methyl-d-aspartate and γ-Aminobutyric Acid Type A Receptor Anesthetic Agents Potentiates Apoptotic Neurodegeneration and Persistent Behavioral Deficits

Fredriksson, A., Pontén, E., Gordh, T., & Eriksson, P. (2007) · Anesthesiology · doi:10.1097/01.anes.0000278892.62305.9c · Cited by 419 · see citing works

Abnormal Glutamate Receptor Expression in the Medial Temporal Lobe in Schizophrenia and Mood Disorders

Beneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., & Meador-Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301312 · Cited by 408 · see citing works

Attention-Deficit/Hyperactivity Disorder After Early Exposure to Procedures Requiring General Anesthesia

Šprung, J., Flick, R. P., Katusic, S. K., Colligan, R. C., Barbaresi, W. J., Bojanić, K., Welch, T. L., Olson, M. D., Hanson, A. C., Schroeder, D. R., et al. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2011.11.008 · Cited by 412 · see citing works

The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia–ischemia

Zhu, C., Wang, X., Xu, F., Bahr, B. A., Shibata, M., Uchiyama, Y., Hagberg, H., & Blomgren, K. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401545 · Cited by 400 · see citing works

Developmental timing and critical windows for the treatment of psychiatric disorders

Marín, O. (2016) · Nature Medicine · doi:10.1038/nm.4225 · Cited by 374 · see citing works

Use of Anesthetic Agents in Neonates and Young Children

Mellon, R. D., Simone, A. F., & Rappaport, B. A. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000255729.96438.b0 · Cited by 395 · see citing works

Neurosensory Impairment after Surgical Closure of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants: Results from the Trial of Indomethacin Prophylaxis in Preterms

Kabra, N. S., Schmidt, B. K., Roberts, R. S., Doyle, L. W., Papile, L. A., & Fanaroff, A. A. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.11.039 · Cited by 368 · see citing works

Anesthesia and Cognitive Performance in Children: No Evidence for a Causal Relationship

Bartels, M., Althoff, R. R., & Boomsma, D. I. (2009) · Twin Research and Human Genetics · doi:10.1375/twin.12.3.246 · Cited by 368 · see citing works

Biologic Effects of Nitrous Oxide

Sanders, R. D., Weimann, J., Maze, M., Warner, D. S., & Warner, M. A. A. (2008) · Anesthesiology · doi:10.1097/aln.0b013e3181870a17 · Cited by 365 · see citing works

Early childhood general anaesthesia exposure and neurocognitive development

Sun, L. S. (2010) · British Journal of Anaesthesia · doi:10.1093/bja/aeq302 · Cited by 364 · see citing works

Propofol: A Review of its Role in Pediatric Anesthesia and Sedation

Chidambaran, V., Costandi, A. J., & D’Mello, A. (2015) · CNS Drugs · doi:10.1007/s40263-015-0259-6 · Cited by 356 · see citing works

Review: Glutamate and dopamine dysregulation in schizophrenia — a synthesis and selective review

Stone, J., Morrison, P., & Pilowsky, L. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106073126 · Cited by 392 · see citing works

Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges

Millar, L., Shi, L., Hoerder-Suabedissen, A., & Molnár, Z. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00078 · Cited by 323 · see citing works

Roles of NMDA receptor activity and nitric oxide production in brain development

Contestabile, A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00018-7 · Cited by 338 · see citing works

Models of schizophrenia in humans and animals based on inhibition of NMDA receptors.

Bubeníková-Valešová, V., Horáček, J., Vrajová, M., & Höschl, C. (2008) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.012 · Cited by 330 · see citing works

The Relationship between Neuronal Survival and Regeneration

Goldberg, J. L., & Barres, B. A. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.579 · Cited by 338 · see citing works

Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia

Bossong, M. G., & Niesink, R. J. M. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.06.010 · Cited by 333 · see citing works

Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

Chen, Z., Jalabi, W., Hu, W., Park, H.-J., Gale, J. T., Kidd, G. J., Bernatowicz, R., Gossman, Z. C., Chen, J. T., Dutta, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5486 · Cited by 319 · see citing works

Academic Performance in Adolescence after Inguinal Hernia Repair in Infancy

Hansen, T. G., Pedersen, J. K., Henneberg, S. W., Pedersen, D. A., Murray, J. C., Morton, N. S., & Christensen, K. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31820e77a0 · Cited by 315 · see citing works

Web-based method for translating neurodevelopment from laboratory species to humans

Clancy, B., Kersh, B., Hyde, J. F., Darlington, R. B., Anand, K. J. S., & Finlay, B. L. (2007) · Neuroinformatics · doi:10.1385/ni:5:1:79 · Cited by 312 · see citing works

Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity

Zhang, S., Zou, M., Lü, L., Lau, D., Ditzel, D. A. W., Delucinge-Vivier, C., Aso, Y., Descombes, P., & Bading, H. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000604 · Cited by 311 · see citing works

Free radicals, mitochondria, and hypoxia–ischemia in the developing brain

Blomgren, K., & Hagberg, H. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.040 · Cited by 310 · see citing works

Altered excitatory-inhibitory balance in the NMDA-hypofunction model of schizophrenia

Kehrer, C. (2008) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.006.2008 · Cited by 287 · see citing works

Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain

Olney, J. W., Tenkova, T. I., Dikranian, K. T., Qin, Y.-Q., Labruyere, J., & Ikonomidou, C. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00279-1 · Cited by 305 · see citing works

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

Hardingham, G. E., & Do, K. Q. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.19 · Cited by 304 · see citing works

Mechanisms underlying hypoxia-induced neuronal apoptosis

Banasiak, K. J., Xia, Y., & Haddad, G. G. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00011-3 · Cited by 302 · see citing works

Decoding NMDA Receptor Signaling: Identification of Genomic Programs Specifying Neuronal Survival and Death

Zhang, S.-J., Steijaert, M. N., Lau, D., Schütz, G., Delucinge-Vivier, C., Descombes, P., & Bading, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.025 · Cited by 304 · see citing works

Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults

Wozniak, D. F., Hartman, R. E., Boyle, M. A., Vogt, S. K., Brooks, A., Tenkova, T. I., YOUNG, C., Olney, J. W., & Muglia, L. J. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.08.006 · Cited by 302 · see citing works

Antiepileptic Drugs and Apoptosis in the Developing Brain

Bittigau, P., Sifringer, M., & Ikonomidou, C. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07517.x · Cited by 303 · see citing works

Revising a Dogma: Ketamine for Patients with Neurological Injury?

Himmelseher, S., & Durieux, M. (2005) · Anesthesia and Analgesia · doi:10.1213/01.ane.0000160585.43587.5b · Cited by 284 · see citing works

Neural circuits subserving behavioral flexibility and their relevance to schizophrenia

Floresco, S. B., Zhang, Y., & Enomoto, T. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.001 · Cited by 298 · see citing works

NMDA receptors in nervous system diseases

Zhou, Q., & Sheng, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.030 · Cited by 293 · see citing works

Developmental Neurotoxicity of Ketamine: Morphometric Confirmation, Exposure Parameters, and Multiple Fluorescent Labeling of Apoptotic Neurons

Scallet, A. C. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh224 · Cited by 298 · see citing works

Drug‐induced Apoptotic Neurodegeneration in the Developing Brain

Olney, J. W., Wozniak, D. F., Jevtović‐Todorović, V., Farber, N. B., Bittigau, P., & Ikonomidou, C. (2002) · Brain Pathology · doi:10.1111/j.1750-3639.2002.tb00467.x · Cited by 295 · see citing works

Neurotransmitters and apoptosis in the developing brain11Abbreviations: GABAA, γ-aminobutyric acid; NMDA; N-methyl-d-aspartate; PCP; phencyclidine; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling.

Ikonomidou, C., Bittigau, P., Koch, C. A., Genz, K., Hoerster, F., Felderhoff‐Mueser, U., Tenkova, T. I., Dikranian, K. T., & Olney, J. W. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00696-7 · Cited by 293 · see citing works

Apoptotic mechanisms and the synaptic pathology of schizophrenia

Glantz, L. A., Gilmore, J. H., Lieberman, J. A., & Jarskog, L. F. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.08.014 · Cited by 289 · see citing works

Glutamate antagonists limit tumor growth

Rzeski, W., Turski, L., & Ikonomidou, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091113598 · Cited by 288 · see citing works

Pyramidal cell regulation of interneuron survival sculpts cortical networks

Wong, F. K., Bercsenyi, K., Sreenivasan, V., Portalés, A., Fernández-Otero, M., & Marín, O. (2018) · Nature · doi:10.1038/s41586-018-0139-6 · Cited by 286 · see citing works

Excitotoxicity in Perinatal Brain Injury

Johnston, M. V. (2005) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00526.x · Cited by 286 · see citing works

Prenatal exposure to interleukin-6 results in inflammatory neurodegeneration in hippocampus with NMDA/GABA A dysregulation and impaired spatial learning

Samuelsson, A., Jennische, E., Hansson, H., & Holmäng, A. B. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00268.2005 · Cited by 283 · see citing works

Isoflurane Anesthesia Induced Persistent, Progressive Memory Impairment, Caused a Loss of Neural Stem Cells, and Reduced Neurogenesis in Young, but Not Adult, Rodents

Zhu, C., Gao, J., Karlsson, N., Li, Q., Zhang, Y., Huang, Z., Li, H., Kuhn, H. G., & Blomgren, K. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.274 · Cited by 283 · see citing works

Neuronal Apoptosis After CNS Injury: The Roles of Glutamate and Calcium

Zipfel, G. J., Babcock, D., Lee, J., & Choi, D. W. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.857 · Cited by 277 · see citing works

Different Strokes for Different Folks: The Rich Diversity of Animal Models of Focal Cerebral Ischemia

Howells, D. W., Porritt, M. J., Rewell, S. S., O'Collins, V., Sena, E. S., van der Worp, H. B., Traystman, R. J., & Macleod, M. R. (2010) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2010.66 · Cited by 309 · see citing works

Summary Proceedings From the Neonatal Pain-Control Group

Anand, K. J. S., Aranda, J. V., Berde, C. B., Buckman, S., Capparelli, E. V., Carlo, W. A., Hummel, P., Johnston, C. C., Lantos, J. D., Lehr, V. T., et al. (2006) · PEDIATRICS · doi:10.1542/peds.2005-0620c · Cited by 278 · see citing works

Xenon Mitigates Isoflurane-induced Neuronal Apoptosis in the Developing Rodent Brain

Ma, D., Williamson, P., Januszewski, A. P., Nogaro, M.-C., Hossain, M., Ong, L. P., Shu, Y., Franks, N. P., & Maze, M. (2007) · Anesthesiology · doi:10.1097/01.anes.0000264762.48920.80 · Cited by 275 · see citing works

Association of Anesthesia and Surgery During Childhood With Long-term Academic Performance

Glatz, P., Sandin, R., Pedersen, N. L., Bonamy, A. E., Eriksson, L. I., & Granath, F. N. (2016) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2016.3470 · Cited by 278 · see citing works

Prolonged seizures and cellular injury: Understanding the connection

Fujikawa, D. G. (2005) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2005.08.003 · Cited by 273 · see citing works

Spontaneous Neuronal Activity in Developing Neocortical Networks: From Single Cells to Large-Scale Interactions

Luhmann, H. J., Sinning, A., Yang, J., Reyes‐Puerta, V., Stüttgen, M. C., Kirischuk, S., & Kilb, W. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00040 · Cited by 275 · see citing works

Development, disease and degeneration in schizophrenia: a unitary pathophysiological model

Keshavan, M. S. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00033-3 · Cited by 272 · see citing works

Are child-, adolescent-, and adult-onset depression one and the same disorder?

Kaufman, J., Martin, A., King, R. A., & Charney, D. S. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01127-1 · Cited by 269 · see citing works

Subanesthetic Doses of Propofol Induce Neuroapoptosis in the Infant Mouse Brain

Cattano, D., Young, C., Straiko, M. M. W., & Olney, J. W. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318172ba0a · Cited by 269 · see citing works

Hypoxic-Ischemic Encephalopathy in the Term Infant

Fatemi, A. S., Wilson, M. A., & Johnston, M. V. (2009) · Clinics in Perinatology · doi:10.1016/j.clp.2009.07.011 · Cited by 267 · see citing works

Interaction of the Tumor Suppressor PTEN/MMAC with a PDZ Domain of MAGI3, a Novel Membrane-associated Guanylate Kinase

Wu, Y. L., Dowbenko, D. J., Spencer, S. D., Laura, R. P., Lee, J., Gu, Q., & Lasky, L. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909741199 · Cited by 267 · see citing works

Isoflurane‐induced apoptosis of oligodendrocytes in the neonatal primate brain

Brambrink, A. M., Back, S. A., Riddle, A., Gong, X., Moravec, M. D., Dissen, G. A., Creeley, C. E., Dikranian, K. T., & Olney, J. W. (2012) · Annals of Neurology · doi:10.1002/ana.23652 · Cited by 264 · see citing works

Anatomical Abnormalities of the Anterior Cingulate Cortex in Schizophrenia: Bridging the Gap Between Neuroimaging and Neuropathology

Fornito, A., Yucel, M., Dean, B., Wood, S. J., & Pantelis, C. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn025 · Cited by 259 · see citing works

Nuclear Ca2+ and the cAMP Response Element-Binding Protein Family Mediate a Late Phase of Activity-Dependent Neuroprotection

Papadia, S., Stevenson, P., Hardingham, N. R., Bading, H., & Hardingham, G. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5019-04.2005 · Cited by 262 · see citing works

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

Hardingham, G. E. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371147 · Cited by 260 · see citing works

Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain

Zou, X., Patterson, T. A., Divine, R. L., Sadovova, N., Zhang, X., Hanig, J. P., Paule, M. G., Slikker, W., & Wang, C. (2009) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2009.06.010 · Cited by 260 · see citing works

Cellular and Molecular Pathways of Ischemic Neuronal Death

Won, S.-J., Kim, D.-Y., & Gwag, B.-J. (2002) · BMB Reports · doi:10.5483/bmbrep.2002.35.1.067 · Cited by 260 · see citing works

Neuronal Death and Oxidative Stress in the Developing Brain

Ikonomidou, C., & Kaindl, A. M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3581 · Cited by 255 · see citing works

NMDA-induced apoptosis in the developing rat brain

Takai, H., Katayama, K., Yasoshima, A., Uetsuka, K., Nakayama, H., & Doi, K. (2003) · Experimental and Toxicologic Pathology · doi:10.1078/0940-2993-00294 · Cited by 8 · see citing works

Shakespeare in love—with NMDA receptors?

Lipton, S. A., & Nakanishi, N. (1999) · Nature Medicine · doi:10.1038/6481 · Cited by 58 · see citing works

How drugs might damage developing brains

Bradbury, J. (1999) · The Lancet · doi:10.1016/s0140-6736(05)76163-8

Ontogeny of the N-Methyl-D-Aspartate (NMDA) Receptor System and Susceptibility to Neurotoxicity

Haberny, K. A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.1.9 · Cited by 218 · see citing works

NMDA receptor activation and apoptosis in developing brain

(1999) · The Neuroscientist · doi:10.1177/107385849900500302