NMDA receptor hypofunction model of schizophrenia

The Rat Brain in Stereotaxic Coordinates

Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585

Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans: Psychotomimetic, Perceptual, Cognitive, and Neuroendocrine Responses

Krystal, J. H. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030035004 · Cited by 3,330

Recent advances in the phencyclidine model of schizophrenia

(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904

Excitatory Amino Acid Transmitters

Watkins, J. C., & Evans, R. H. (1981) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001121 · Cited by 2,497

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W. (1999) · Science · doi:10.1126/science.283.5398.70 · Cited by 2,055

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793

Glutamate receptor dysfunction and schizophrenia

Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685

Ketamine—its pharmacology and therapeutic uses

white, P. F., Way, W. L., & Trevor, A. J. (1982) · Anesthesiology · doi:10.1097/00000542-198202000-00007 · Cited by 1,474

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

Olney, J. W., Labruyere, J., & Price, M. T. (1989) · Science · doi:10.1126/science.2660263 · Cited by 1,230

Study of a New Schizophrenomimetic Drug—Sernyl

LUBY, E. D. (1959) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1959.02340150095011 · Cited by 921

Poly(I:C) Challenge Alters Brain Expression of Oligodendroglia-Related Genes of Adult Progeny in a Mouse Model of Maternal Immune Activation

Zhang, X., Chen, T., Yan, A., Xiao, J., Xie, Y., Yuan, J., Chen, P., Wong, A., Zhang, Y., & Wong, N.-K. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00115 · Cited by 26

Ketamine use disorder: preclinical, clinical, and neuroimaging evidence to support proposed mechanisms of actions

Vines, L., Sotelo, D., Johnson, A., Dennis, E., Manza, P., Volkow, N. D., & Wang, G. (2022) · Intelligent Medicine · doi:10.1016/j.imed.2022.03.001 · Cited by 26

Theta/gamma Co-modulation Disruption After NMDAr Blockade by MK-801 Is Associated with Spatial Working Memory Deficits in Mice

Abad-Perez, P., Payá, F. J. M., Martínez-Otero, L., Borrell, V., Redondo, R. L., & Brotons‐Mas, J. R. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.03.022 · Cited by 26

Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti‐ N ‐methyl‐ d ‐aspartate receptor antibodies

Kawano, H., Hamaguchi, E., Kawahito, S., Tsutsumi, Y. M., Tanaka, K., Kitahata, H., & Oshita, S. (2011) · Anaesthesia · doi:10.1111/j.1365-2044.2011.06707.x · Cited by 25

Latent inhibition in 35-day-old rats is not an "adult" latent inhibition: implications for neurodevelopmental models of schizophrenia

Zuckerman, L., Rimmerman, N., & Weiner, I. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1460-8 · Cited by 25

Coumarin effects on amino acid levels in mice prefrontal cortex and hippocampus

Lucetti, E. C. P., Lucetti, D. L., Barbosa‐Filho, J. M., de Brito, E. M., Monteiro, V. S., Patrocínio, M. C. A., de Moura, R. R., Leal, L. K. A. M., Macêdo, D. S., de Sousa, F. C. F., et al. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.03.009 · Cited by 25

Multidimensional Connectomics and Treatment-Resistant Schizophrenia: Linking Phenotypic Circuits to Targeted Therapeutics

MacKay, M.-A. B., Paylor, J. W., Wong, J. T. F., Winship, I. R., Baker, G. B., & Dursun, S. M. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00537 · Cited by 27

The effects of the glutamate antagonist memantine on brain activation to an auditory perception task

van Wageningen, H., Jørgensen, H. A., Specht, K., Eichele, T., & Hugdahl, K. (2009) · Human Brain Mapping · doi:10.1002/hbm.20789 · Cited by 26

A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.

Steullet, P., Lavoie, S., Kraftsik, R., Guidi, R., Gysin, R., Cuenod, M., & Do, K. (2008) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2007.12.006 · Cited by 29

Transcriptional Regulation of NMDA Receptor Expression

Bai, G., & Hoffman, P. W. (2008) · Frontiers in neuroscience · doi:10.1201/9781420044157.ch5 · Cited by 26

Regulation of Glutamate Carboxypeptidase II Function in Corticolimbic Regions of Rat Brain by Phencyclidine, Haloperidol, and Clozapine

Flores, C., & Coyle, J. T. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300129 · Cited by 25

Activation of a nitric-oxide-sensitive cAMP pathway with phencyclidine: elevated hippocampal cAMP levels are temporally associated with deficits in prepulse inhibition

Klamer, D., P�lsson, E., Fejgin, K., Zhang, J., Engel, J. A., & Svensson, L. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2051-z · Cited by 26

Deletion of Glycogen Synthase Kinase-3β in D2 Receptor–Positive Neurons Ameliorates Cognitive Impairment via NMDA Receptor–Dependent Synaptic Plasticity

Li, Y.-C., Panikker, P., Xing, B., Yang, S.-S., Alexandropoulos, C., McEachern, E., Akumuo, R. C., Zhao, E. E., Gulchina, Y., Pletnikov, M. V., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.10.025 · Cited by 24

N-methyl-D-aspartate receptor availability in first-episode psychosis: a PET-MR brain imaging study

Beck, K., Arumuham, A., Veronese, M., Santangelo, B., McGinnity, C., Dunn, J., McCutcheon, R., Kaar, S., Singh, N., Pillinger, T., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01540-2 · Cited by 20

Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats

Olsen, C., Kreilgaard, M., & Didriksen, M. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.05.006 · Cited by 24

Oestradiol attenuates the cognitive deficit induced by acute phencyclidine treatment in mature female hooded-Lister rats

Sutcliffe, J., Rhaman, F., Marshall, K. M., & Neill, J. C. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107083839 · Cited by 23

mGluR5 positive allosteric modulation and its effects on MK-801 induced set-shifting impairments in a rat operant delayed matching/non-matching-to-sample task

LaCrosse, A., Burrows, B. T., Angulo, R. M., Conrad, P. R., Himes, S. M., Mathews, N., Wegner, S. A., Taylor, S. B., & Olive, M. F. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3653-8 · Cited by 25

Investigating Cortical Inhibition in First-Degree Relatives and Probands in Schizophrenia

Radhu, N., Dominguez, L. G., Greenwood, T. A., Farzan, F., Semeralul, M. O., Richter, M. A., Kennedy, J. L., Blumberger, D. M., Chen, R. E., Fitzgerald, P. B., et al. (2017) · Scientific Reports · doi:10.1038/srep43629 · Cited by 26

Visual Attention Decits in Schizophrenia Can Arise From Inhibitory Dysfunction in Thalamus or Cortex

John, Y. J., Zikopoulos, B., Bullock, D. H., & Barbas, H. (2018) · Computational Psychiatry · doi:10.1162/cpsy_a_00023 · Cited by 22

Genetic analysis of the DLGAP1 gene as a candidate gene for schizophrenia

Li, J., Lu, C.-L., Cheng, M.-C., Luu, S.-U., Hsu, S.-H., & Chen, C. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.08.014 · Cited by 24

Environmental Agents That Have the Potential to Trigger Massive Apoptotic Neurodegeneration in the Developing Brain

Olney, J. W., Farber, N. B., Wozniak, D. F., Jevtović‐Todorović, V., & Ikonomidou, C. (2000) · Environmental Health Perspectives · doi:10.2307/3454524 · Cited by 24

A spatial threshold for astrocyte calcium surgePreprint

Lines, J., Baraibar, A. M., Nanclares, C., Martín, E. D., Aguilar, J., Kofuji, P., Navarrete, M., & Araque, A. (2023) · eLife · doi:10.7554/elife.90046 · Cited by 24

Human Complement C4B Allotypes and Deficiencies in Selected Cases With Autoimmune Diseases

Zhou, D., Rudnicki, M., Chua, G. T., Lawrance, S. K., Zhou, B., Drew, J., Barbar-Smiley, F. A., Armstrong, T., Hilt, M. E., Birmingham, D. J., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.739430 · Cited by 23

Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia

Marballi, K. K., Alganem, K., Brunwasser, S. J., Barkatullah, A., Meyers, K. T., Campbell, J. M., Ozols, A. B., McCullumsmith, R. E., & Gallitano, A. L. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02069-8 · Cited by 21

Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning

Sun, X., Pinacho, R., Saia, G., Punko, D., Meana, J. J., Ramos, B., & Gill, G. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22212 · Cited by 23

Discovery and Characterization of a Novel Dihydroisoxazole Class of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators

Patel, N. C., Schwarz, J. B., Hou, X., Hoover, D. J., Xie, L., Fliri, A. F. J., Gallaschun, R. J., Lazzaro, J. T., Bryce, D. K., Hoffmann, W. E., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm401274b · Cited by 23

Mismatch Negativity/P3a Complex in Young People with Psychiatric Disorders: A Cluster Analysis

Kaur, M., Lagopoulos, J., Ward, P. B., Watson, T., Naismith, S. L., Hickie, I. B., & Hermens, D. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051871 · Cited by 23

α4β2 nicotinic receptor stimulation of the GABAergic system within the orbitofrontal cortex ameliorates the severe crossmodal object recognition impairment in ketamine-treated rats: Implications for cognitive dysfunction in schizophrenia

Cloke, J. M., & Winters, B. D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.004 · Cited by 26

Neuroprotective effects of olanzapine in a rat model of neurodevelopmental injury

Csernansky, J. G., Martin, M. V., Czeisler, B. M., Meltzer, M. A., Ali, Z., & Dong, H. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.01.009 · Cited by 23

Redox Dysregulation in Schizophrenia: Genetic Susceptibility and Pathophysiological Mechanisms

Do, K. Q., Bovet, P., Cabungcal, J.-H., Conus, P., Gysin, R., Lavoie, S., Steullet, P., & Cuénod, M. (2009) · Springer eBooks · doi:10.1007/978-0-387-30410-6_8 · Cited by 22

Nitric oxide synthase inhibition attenuates phencyclidine-induced disruption of cognitive flexibility

Wass, C., Svensson, L., Fejgin, K., Pålsson, E., Archer, T., Engel, J. A., & Klamer, D. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.01.011 · Cited by 22

Selective interaction of nitric oxide synthase inhibition with phencyclidine: behavioural and NMDA receptor binding studies in the rat

Klamer, D., Zhang, J., Engel, J. A., & Svensson, L. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.10.006 · Cited by 23

Proton magnetic resonance spectroscopy of the substantia nigra in schizophrenia

Reid, M. A., Kraguljac, N. V., Avsar, K. B., White, D. M., den Hollander, J. A., & Lahti, A. C. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.04.036 · Cited by 22

Neurochemical, behavioral and architectural changes after chronic inactivation of NMDA receptors in mice

Elhardt, M. E., Martinez, L. A., & Tejada-Simon, M. V. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.10.091 · Cited by 22

EEG Findings of Reduced Neural Synchronization during Visual Integration in Schizophrenia

Wynn, J. K., Roach, B. J., Lee, J., Horan, W. P., Ford, J. M., Jimenez, A. M., & Green, M. F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119849 · Cited by 22

Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1

Blackaby, W., Lewis, R. T., Thomson, J. L., Jennings, A. S. R., Goodacre, S. C., Street, L. J., MacLeod, A. M., Pike, A. J., Wood, S., Thomas, S., et al. (2010) · ACS Medicinal Chemistry Letters · doi:10.1021/ml1001085 · Cited by 22

Reduced in vivo visual cortex GABA in schizophrenia, a replication in a recent onset sample

Yoon, J. H., Maddock, R. J., Cui, E., Minzenberg, M., Niendam, T. A., Lesh, T. A., Solomon, M., Ragland, J. D., & Carter, C. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.10.025 · Cited by 22

Discovery of GlyT1 inhibitors with improved pharmacokinetic properties

Wolkenberg, S. E., Zhao, Z., Wisnoski, D. D., Leister, W., O'Brien, J. L., Lemaire, W., Williams, D. L., Jacobson, M. A., Sur, C., Kinney, G. G., et al. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.01.015 · Cited by 22

The antidepressant phenelzine enhances memory in the double Y-maze and increases GABA levels in the hippocampus and frontal cortex of rats

Simpson, S. M., Hickey, A. J., Baker, G. B., Reynolds, J. N., & Beninger, R. J. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.03.027 · Cited by 22

Enhanced Dopamine-Dependent Hippocampal Plasticity after Single MK-801 Application

Bartsch, J., Fidzinski, P., Huck, J. H. J., Hörtnagl, H., Kovács, R., Liotta, A., Priller, J., Wozny, C., & Behr, J. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.276 · Cited by 22

Protective effect of the antipsychotic drug zotepine on dizocilpine-induced neuropathological changes in rat retrosplenial cortex

Okamura, N., Hashimoto, K., Kanahara, N., Shimizu, E., Kumakiri, C., Komatsu, N., & Iyo, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01303-7 · Cited by 22

Implication of neuronal Ca2+-sensor protein VILIP-1 in the glutamate hypothesis of schizophrenia

Gierke, P., Zhao, C., Bernstein, H., Noack, C., Anand, R., Heinemann, U., & Braunewell, K. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.07.008 · Cited by 23

MicroRNAs in schizophrenia: implications for synaptic plasticity and dopamine–glutamate interaction at the postsynaptic density. New avenues for antipsychotic treatment under a theranostic perspective

de Bartolomeis, A., Iasevoli, F., Tomasetti, C., & Buonaguro, E. F. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8962-8 · Cited by 21

Neuropharmacology of altered brain oscillations in schizophrenia

Koch, M., Schmiedt‐Fehr, C., & Mathes, B. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.02.014 · Cited by 21

Glutamate metabolites in treatment resistant schizophrenia: A meta-analysis and systematic review of 1H-MRS studies

Kumar, V., Manchegowda, S., Jacob, A., & Rao, N. P. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111080 · Cited by 21

Increased use of ketamine for the treatment of depression: Benefits and concerns

Na, K., & Kim, Y. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110060 · Cited by 23

Activation of dopamine D1 receptors blocks phencyclidine‐induced neurotoxicity by enhancing N‐methyl‐D‐aspartate receptor‐mediated synaptic strength

Lei, G., Anastasio, N. C., Fu, Y., Neugebauer, V., & Johnson, K. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06030.x · Cited by 21

Effect of isolation rearing on the expression of AMPA glutamate receptors in the hippocampal formation

Sestito, R. S., Trindade, L. B., de Souza, R. G., Kerbauy, L. N., Iyomasa-Pilon, M. M., & Rosa, M. L. N. M. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110385595 · Cited by 22

Cognitive ‘Omics’: Pattern-Based Validation of Potential Drug Targets

Gyertyán, I. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.10.010 · Cited by 20

Selective allosteric modulation of muscarinic acetylcholine receptors for the treatment of schizophrenia and substance use disorders

Teal, L. B., Gould, R. W., Felts, A. S., & Jones, C. K. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.05.001 · Cited by 20

Comparative analyses of the neurodegeneration induced by the non-competitive NMDA-receptor-antagonist drug MK801 in mice and rats

Bender, C. L., de Olmos, S., Bueno, A. M., de Olmos, J. S., & Lorenzo, A. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.05.002 · Cited by 21

Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors

Zhao, Z., Leister, W., O’Brien, J. A., Lemaire, W., Williams, D. L., Jacobson, M. A., Sur, C., Kinney, G. G., Pettibone, D. J., Tiller, P. R., et al. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.12.115 · Cited by 21

Hypofunction of the dorsal hippocampal NMDA receptors impairs retrieval of memory to partially presented foreground context in a single-trial fear conditioning in rats

Melik, E., Babar, E., Ozen, E., & Özgünen, T. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.07.008 · Cited by 21

Schizophrenia: Putting context in context

Park, S., Lee, J., Folley, B. S., & Kim, J. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03380021 · Cited by 21

Genetics of epilepsy: Epilepsy Research Foundation workshop report

Sisodiya, S. M., Cross, J. H., Blümcke, I., Chadwick, D. W., Craig, J. J., Crino, P. B., Debenham, P., Delanty, N., Elmslie, F., Gardiner, M., et al. (2007) · Epileptic Disorders · doi:10.1684/epd.2007.0107 · Cited by 21

Glutamate levels in the anterior cingulate cortex in un-medicated first episode psychosis: a proton magnetic resonance spectroscopy study

Borgan, F., Jauhar, S., McCutcheon, R. A., Pepper, F., Rogdaki, M., Lythgoe, D. J., & Howes, O. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-45018-0 · Cited by 21

Handbook of neurochemistry and molecular neurobiology, schizophrenia

Lajtha, Á., Javitt, D. C., & Kantrowitz, J. T. (2009) · Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) · doi:10.1007/978-0-387-30410-6 · Cited by 21

Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open field

McLean, S. L., Woolley, M. L., & Neill, J. C. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109103112 · Cited by 21

HIV-associated dementia, Alzheimer's disease, multiple sclerosis, and schizophrenia: gene expression review.

Minagar, A., Shapshak, P., Duran, E. M., Kablinger, A. S., Alexander, J., Kelley, R. E., Seth, R., & Kazic, T. (2004) · Journal of Neurological Sciences · doi:10.1016/j.jns.2004.06.007 · Cited by 21

Translating preclinical findings in clinically relevant new antipsychotic targets: focus on the glutamatergic postsynaptic density. Implications for treatment resistant schizophrenia

de Bartolomeis, A., Avagliano, C., Vellucci, L., D’Ambrosio, L., Manchia, M., D’Urso, G., Buonaguro, E. F., & Iasevoli, F. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.08.019 · Cited by 19

Pharmaco-Magnetic Resonance as a Tool for Monitoring the Medication-Related Effects in the Brain May Provide Potential Biomarkers for Psychotic Disorders

Aryutova, K., & Stoyanov, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179309 · Cited by 20

Behavioral Neurobiology of Bipolar Disorder and its Treatment

Manji, H. K., & Zarate, C. A. (2010) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-15757-8 · Cited by 20

Enduring Neuroprotective Effect of Subacute Neural Stem Cell Transplantation After Penetrating TBI

Kassi, A., Mahavadi, A. K., Clavijo, A., Caliz, D., Lee, S. W., Ahmed, A. I., Yokobori, S., Hu, Z., Spurlock, M. S., Wasserman, J. M., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2018.01097 · Cited by 20

Neuronal NMDAR Currents of the Hippocampus and Learning Performance in Autoimmune Anti-NMDAR Encephalitis and Involvement of TNF-α and IL-6

Wang, X., Ma, C., Liu, C., Li, G., Zhao, D., & Han, D. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00684 · Cited by 20

Sleep and Plasticity in Schizophrenia

Sprecher, K. E., Ferrarelli, F., & Benca, R. M. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_366 · Cited by 20

Rivastigmine reverses cognitive deficit and acetylcholinesterase activity induced by ketamine in an animal model of schizophrenia

Zugno, A. I., Julião, R. F., Budni, J., Volpato, A. M., Fraga, D. B., Pacheco, F. D., Deroza, P. F., Luca, R. D. D., de Oliveira, M. B., Heylmann, A. S., et al. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9417-z · Cited by 20

The effect of ((−)-2-oxa-4-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY379268), an mGlu2/3 receptor agonist, on EEG power spectra and coherence in ketamine model of psychosis

Fujáková, M., Páleníček, T., Brunovský, M., Gorman, I., Tylš, F., Kubešová, A., Řı́pová, D., Krajča, V., & Horáček, J. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.03.001 · Cited by 20

Antisense hippocampal knockdown of NMDA-NR1 by HVJ-liposome vector induces deficit of prepulse inhibition but not of spatial memory

Inada, K., Ishigooka, J., Anzai, T., Suzuki, E., Miyaoka, H., & Saji, M. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(03)00012-9 · Cited by 20

Update Anti-N-Methyl-D-Aspartat-Rezeptor-Enzephalitis

Kovac, S., Alferink, J., Ahmetspahic, D., Arolt, V., & Melzer, N. (2017) · Der Nervenarzt · doi:10.1007/s00115-017-0405-0 · Cited by 19

Disorganization of Oscillatory Activity in Animal Models of Schizophrenia

Speers, L. J., & Bilkey, D. K. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.741767 · Cited by 21

Electrophysiological and behavioral responses to ketamine in mice with reduced Akt1 expression

Featherstone, R. E., Tatard-Leitman, V. M., Suh, J., Lin, R., Lucki, I., & Siegel, S. J. (2013) · Psychopharmacology · doi:10.1007/s00213-013-2997-9 · Cited by 20

D-Amphetamine and Antipsychotic Drug Effects on Latent Inhibition in Mice Lacking Dopamine D2 Receptors

Bay-Richter, C., O’Callaghan, M. J., Mathur, N., O’Tuathaigh, C. M. P., Heery, D. M., Fone, K. C. F., Waddington, J. L., & Moran, P. M. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.50 · Cited by 19

A Novel Multisensory Integration Task Reveals Robust Deficits in Rodent Models of Schizophrenia: Converging Evidence for Remediation via Nicotinic Receptor Stimulation of Inhibitory Transmission in the Prefrontal Cortex

Cloke, J. M., Nguyen, R., Chung, B. Y. T., Wasserman, D., Lisio, S. D., Kim, J. C., Bailey, C. D. C., & Winters, B. D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1628-16.2016 · Cited by 21

A high-throughput model for investigating neuronal function and synaptic transmission in cultured neuronal networks

Virdee, J. K., Sarò, G., Fouillet, A., Findlay, J. D., Ferreira, F. M., Eversden, S., O’Neill, M. J., Wolak, J., & Ursu, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-15171-5 · Cited by 18

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Bégou, M., Brun, P., Bertrand, J., Job, D., Schweitzer, A., d’Amato, T., Saoud, M., Andrieux, A., & Suaud‐Chagny, M. (2007) · Synapse · doi:10.1002/syn.20409 · Cited by 19

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Zuo, D., Cao, Y., Zhang, L., Wang, H., & Wu, Y. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.12.002 · Cited by 19

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Alberati, D., Moreau, J., Mory, R., Pinard, E., & Wettstein, J. G. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.07.016 · Cited by 18

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Garson, J. (2006) · Texas ScholarWorks (Texas Digital Library) · Cited by 18

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