Cited by 189Advanced MRI Techniques and ApplicationsDementia and Cognitive Impairment ResearchFunctional Brain Connectivity Studies

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Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: effect of aging

Bentourkia, M’hamed, Bol, Anne, Ivanoiu, Adrian, Labar, Daniel, Sibomana, Mérence, Coppens, Ann, Michel, Christian, Cosnard, Guy, De Volder, Anne G·2000·Journal of the Neurological Sciences

DOI 10.1016/s0022-510x(00)00396-8

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Abstract

The regional cerebral blood flow (rCBF) and metabolic rate for glucose (rCMRGlc) are associated with functional activity of the neural cells. The present work reports a comparison study between rCBF and rCMRGlc in a normal population as a function of age. 10 young (25.9+/-5.6 years) and 10 old (65.4+/-6.1 years) volunteers were similarly studied at rest. In each subject, rCBF and rCMRGlc were measured in sequence, during the same session. Both rCBF and rCMRGlc values were found to decrease from young (mean rCBF=43.7 ml/100 g per min; mean rCMRGlc=40.6 micromol/100 g per min) to old age (mean rCBF=37.3 ml/100 g per min; mean rCMRGlc=35.2 micromol/100 g per min), resulting in a drop over 40 years of 14.8% (0.37%/year) and 13.3% (0.34%/year), respectively. On a regional basis, the frontal and the visual cortices were observed to have, respectively, the highest and the lowest reduction in rCBF, while, for rCMRGlc, these extremes were observed in striatum and cerebellum. Despite these differences, the ratio of rCBF to rCMRGlc was found to have a similar behavior in all brain regions for young and old subjects as shown by a correlation coefficient of 88%. This comparative study indicates a decline in rCBF and rCMRGlc values and a coupling between CBF and CMRGlc as a function of age.

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Authors: Bentourkia, M., Bol, A., Ivanoiu, A., Labar, D., Sibomana, M., Coppens, A., Michel, C., Cosnard, G., & De Volder, A. G.
Affiliations: UCLouvain (BE)
ORCID: Bentourkia, M’hamed
Michel, Christian
Venue: Journal of the Neurological Sciences
Publisher: Elsevier BV
Published: 2000-12
Volume: 181
Issue: 1-2
Pages: 19-28
ISSN: 0022-510X (ISSN-L)
DOI: 10.1016/s0022-510x(00)00396-8
OpenAlex: W1963947389
Cited by: 189
References: 57
Citations by year: 2026: 2 · 2025: 2 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 11 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 4 · 2013: 11 · 2012: 9
FWCI: 3.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the Neurological Sciences (publishedVersion)
PubMed (publishedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: regional cerebral blood flow, brain glucose metabolism, aging, brain aging, frontal cortex, visual cortex, striatum, cerebellum, regional brain metabolism, normal brain
MeSH terms: Adult, Aged, Aging, Brain, Cerebrovascular Circulation, Female, Glucose, Humans, Male, Middle Aged, Tomography, Emission-Computed

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Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: effect of aging

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